2022 Nov 23
1
Department of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
2
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden ...
Health effects of milk consumption: phenome-wide Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/36424608/
Abstract
Background: We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population.
Methods: Rs4988235 located upstream of the LCT gene was used as the instrumental variable for milk consumption. MR-PheWAS analysis was conducted to map the association of genetically predicted milk consumption with 1081 phenotypes in the UK Biobank study (n=339,197). The associations identified in MR-PheWAS were examined by two-sample MR analysis using data from the FinnGen study (n=260,405) and international consortia. A systematic review of MR studies on milk consumption was further performed.
Conclusions: This study suggests several health effects of milk consumption in the European population.
Results: PheWAS and two-sample MR analyses found robust evidence in support of inverse associations of genetically predicted milk consumption with risk of cataract (odds ratio (OR) per 50 g/day increase in milk consumption, 0.89, 95% confidence interval (CI), 0.84-0.94; p=3.81×10-5), hypercholesterolemia (OR, 0.91, 95% CI 0.86-0.96; p=2.97×10-4), and anal and rectal polyps (OR, 0.85, 95% CI, 0.77-0.94; p=0.001). An inverse association for type 2 diabetes risk (OR, 0.92, 95% CI, 0.86-0.97; p=0.003) was observed in MR analysis based on genetic data with body mass index adjustment but not in the corresponding data without body mass index adjustment. The systematic review additionally found evidence that genetically predicted milk consumption was inversely associated with asthma, hay fever, multiple sclerosis, colorectal cancer, and Alzheimer's disease, and positively associated with Parkinson's disease, renal cell carcinoma, metabolic syndrome, overweight, and obesity.
Milk
Milk
https://www.eboro.cz
Re: Milk
In plain English can anyone tell us what this means? Does milk increase or decrease the risk of MS?
Re: Milk
The full text is available for free.
https://www.ncbi.nlm.nih.gov/pmc/articl ... po=29.5455
It states...
The results reported for MS come from one reference. The full version of which is also available.For disease outcomes, genetically predicted higher milk consumption was associated with a lower risk of asthma, hay fever, multiple sclerosis, colorectal cancer, and Alzheimer’s disease, and a higher risk of Parkinson’s disease, renal cell carcinoma, metabolic syndrome, overweight and obesity (Fig.3).
Intake and Risk of Neurodegenerative Diseases.
Nutrients. 2021;13(8).
Another paper reports that dairy is not a problem with MS. They also state that consuming yogurt reduced the risks of an MS diagnosis. This effect was proposed to be due the activity of the probiotics. However, I would be careful to avoid the sweetened yogurts. Many sweetened yogurts contain as much sugar as a can of Coke. The full text is available.
Total Dairy Consumption Is Not Associated With Likelihood of a First Clinical Diagnosis of Central Nervous System Demyelination
Front Neurol. 2022 May 13;13:888559.
These results are in conflict with well known MS diets. For example, both Ashton Embry’s Best Bet Diet and Terry Wahls’ Diet which recommend the elimination of dairy products. Terry Wahls indicates that the issue is with
casein protein.
She discusses the details of her diet in several of her video preventions.
The are several papers that discuss casein and MS at PubMed.
https://pubmed.ncbi.nlm.nih.gov/?term=C ... sclerosis”
I suspect that the different perspectives on dairy is due to the fact that some of the papers discuss the risk of being diagnosed with MS while other papers are discussing the risk of dairy in established MS.