This Is MS Multiple Sclerosis Knowledge & Support Community

jimmylegs wrote:@NZ that was a good LOL

why yes now that you say so, it does occur to me

If this keeps up, we may start asking for directions, heavens forbid.

Extreme measures?

Mushrooms can provide as much vitamin D as supplements - but only if you put them in the sun before you eat them
Mushrooms transform UV light into vitamin D
Sun-exposed mushrooms are as effective at boosting and maintaining vitamin D levels as supplements are
Have to be in summer sun for 60 minutes to produce vitamin D - cooking doesn't reduce the vitamin level

http://www.dailymail.co.uk/health/artic ... -them.html

Thought you might have been in the dark about this info!:)


;)
Nigel

NZer1 wrote:Mushrooms can provide as much vitamin D as supplements - but only if you put them in the sun before you eat them
Mushrooms transform UV light into vitamin D
Sun-exposed mushrooms are as effective at boosting and maintaining vitamin D levels as supplements are
Have to be in summer sun for 60 minutes to produce vitamin D - cooking doesn't reduce the vitamin level

http://www.dailymail.co.uk/health/artic ... -them.html

Thought you might have been in the dark about this info!:)


;)
Nigel

In the dark and being covered in sh*it.

To get 4,000 IU a day by eating white button mushrooms, you would only need to eat 4 kgs.

There are MAJOR differences in the Vitamin D content of different types of mushrooms. Some are quite high, as much as 2500 IU (Maitake), but everyday button mushrooms only have a few IU per 100 grams.

Some good information on the vitamin D content of mushrooms can be found here.

A good source of information on the nutritional value of foods, including things like Vitamin D can be found here.

“Examining this small group of patients with vitamin D deficiency who experienced symptoms of muscle fatigue, we found that those with very low vitamin D levels improved their muscle efficiency significantly when their vitamin D levels were improved.”
http://www.ncl.ac.uk/press.office/press ... XmbiKKBnoB

This article is quite long AND it has some interesting pieces that connect the Vit D and other Vits such as Zinc and Magnesium, plus minerals that require each other to be bio-available as Jimmylegs has been saying!

"In the last decade the majority of outcome-oriented physicians observed a major shift: we realized that it was neither the lack of vitamins or growth hormone that made our patients ill. We discovered that toxicity and chronic infections were most often at the core of the client’s suffering. We watched the discussion, which infection may be the primary one: mycoplasma, stealth viruses, HHV-6, trichomonas, Chlamydia pneumoniae, leptospirosis, mutated strep, or what else?"
http://www.samento.com.ec/sciencelib/4l ... otics.html

Magnesium is a key mineral throughout the body, and is important to the Mitochondria to produce energy.
http://www.nutritionsecurity.org/PDF/Mi ... 0Apple.pdf

NZer1 wrote:Magnesium is a key mineral throughout the body, and is important to the Mitochondria to produce energy.
http://www.nutritionsecurity.org/PDF/Mi ... 0Apple.pdf

This is true but Mg is not the only key mineral. Jimmylegs has mentioned 5 in many posts. My advice is simple:
Vit D3=125 nmol/L min in blood. FIRST SMALL STEP for pwMS
If a person with MS or any other low vit D3 result does not increase their vit D3 level significantly with 5000iu/day then they need testing and expert advice on a range of minerals. The best way to get vit D is from the sun but for most pwMS this is not an option cos we cannot get sunshine where we live. 5000iu vit D3 is a small cheap capsule in a bioavailable form which is more cost effective than sun dried mushrooms.
MarkW

like this one
Step 1: Assess/Correct Your Nutrient Imbalances
http://www.thisisms.com/forum/chronic-c ... 17004.html
MS Nutrition-summary pts 1st post, p.1
http://www.thisisms.com/forum/regimens- ... c2489.html

you can be even more cost effective with vit d3, by optimizing zinc status first to maximize absorption plus you get all those other benefits relevant to ms patients yay!

Interesting conclusion simple but wr.....
"Multiple sclerosis has skyrocketed in Tehran, increasing almost sevenfold between 1989 and 2005. In Iran’s central province of Isfahan, the incidence nearly tripled from 2005 to 2009. Now Oxford University researchers suggest, for the first time, that the 1979 Iranian Revolution may deserve some of the blame for the extraordinary jump. They say the revolutionary mandate for modest dress and head coverings for women may have inadvertently fueled the increase by limiting their exposure to sunlight."

Read more: http://www.smithsonianmag.com/science-n ... 15701.html

that's funny I wrote a paper for school in 2006 that linked European clothes on dark skinned indigenous people to vit d3 deficiency and their associated overrepresentation in pretty much every disease that was covered in a 2005 Aboriginal and Torres Strait Islander health report of some kind.. cant recall exactly what the report was called. one of the references had a great table, I should look it up. It was along the lines of a table with palest to darkest skin down one side, bare skin to totally covered across the top, and in each table cell the percent of people studied with d3 deficiency. naturally the pale folks with bare skin had the fewest deficiency numbers, but deficiency was through the roof for the dark-skinned covered up subjects.

RESULTS: There is comprehensive evidence from epidemiological, observational, and experimental studies that vitamin D may be beneficial in MS. In case you want more info..................MarkW

Acta Neurol Scand Suppl. 2013;(196):16-23. doi: 10.1111/ane.12045.
Fat-soluble vitamins as disease modulators in multiple sclerosis.
Torkildsen Ø, Løken-Amsrud KI, Wergeland S, Myhr KM, Holmøy T.
Source
Department of Neurology, Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway.
Abstract
BACKGROUND:
Fat-soluble vitamins (A, D, E and K) have properties that could be relevant as modulators of disease activity in multiple sclerosis (MS).
METHODS:
We performed a systematic search on PubMed and Medline up to May 2012, using the search strings 'vitamin A', 'retinol', 'retinal', 'carotenoids', 'vitamin D', 'vitamin E', 'alpha-tocopherol', 'vitamin K' in conjunction with 'multiple sclerosis', 'animal model' and 'experimental autoimmune encephalitis (EAE)'. In addition, the reference lists of the publications identified were examined for further citations of relevance.
RESULTS:
There is comprehensive evidence from epidemiological, observational, and experimental studies that vitamin D may be beneficial in MS. Results from small-scale clinical studies are inconclusive, and large-scale, adequately powered, randomized, controlled trials are still lacking. For vitamin D, Oxford Centre for Evidence-Based Medicine level 2c evidence exists for a positive therapeutic effect. Evidence from animal models indicates that all the examined fat-soluble vitamins could have potential as modulators of disease activity in MS. For vitamin A and E, level 4 and 5 evidence exists for a modulatory effect in MS; for vitamin K, too few studies have been conducted to indicate an effect in humans.
CONCLUSION:
Vitamin D is a promising candidate as modulator of disease activity in MS, and controlled studies are currently being conducted. All the fat-soluble vitamins have, however, been demonstrated to be effective in different animal models for the disease, and vitamin A and E have biological properties that could be relevant for MS pathogenesis. Thus, vitamin A and E seem to be promising candidates for future case-control and cohort studies.
© 2012 John Wiley & Sons A/S.
PMID: 23190287 [PubMed - indexed for MEDLINE]

Some insights to why the Vit D supplementation is not a simple answer to a complex problem;
Quote,
"Gene transfer

The main problem in Th1/Th17 diseases is that the VDR, which controls much of the innate immune system, seems to be blocked by bacterial ligands. There are many types of bacterial species at work that can transfer genes horizontally, and focusing on just one is an error.

The L-form bacteria enter the cell via endocytosis or some other means. We think they have a way to block the vitamin D nuclear receptor (VDR) ligand with a protein antagonist (perhaps capnine). The problem is that the phagocytes, while successfully engulfing the bacteria, are unable to kill them.

Transcription for specific genes occurs when the correct promoters and enhancers are provided by the activated VDR to separate the DNA double helix at the correct gene location and make the complement mRNA coded for a protein. The mRNA then returns to the cytoplasm to be translated into protein by the cell ribosomes.

However, when an antagonist is attached to the VDR ligand, the VDR is not in the correct physical shape to enter the nucleus through the nuclear membrane pores to access DNA where it would normally transcribe 900+ genes into mRNA. Many of these proteins are critical to the function of the immune system.

One researcher, using computer molecular modeling and affinity calculations, has determined that Benicar is a VDR agonist (activates the VDR), and in high enough concentrations will dislodge the bacterial antagonist (which inhibit VDR function). Over time, Inflammation Therapy will allow the hormone 1,25-D to regain homeostasis with the VDR and reactivate the immune system on its own."

https://www.chronicillnessrecovery.org/ ... 5&Itemid=5

;)
Nigel

Jimmylegs there is some very good info on vits and mins regarding the deficiency and synthesis as well!

thx i'll check it out