My Brother's Condition (update)

A forum to discuss the Coimbra Protocol which uses high-dose vitamin D3 to treat multiple sclerosis.
mrtmeo
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Location: Wisconsin, USA

Re: My Brother's Condition (update)

Post by mrtmeo »

Hi Antonio,
Does your brother have kidney issues or normal GFR?
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
AntonioBR
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Joined: Sat Dec 12, 2015 11:06 am

Re: My Brother's Condition (update)

Post by AntonioBR »

mrtmeo wrote:Hi Antonio,
Does your brother have kidney issues or normal GFR?
All the tests show that his kidneys are fine.

He never had kidney problems.
mrtmeo
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Location: Wisconsin, USA

Re: My Brother's Condition (update)

Post by mrtmeo »

AntonioBR wrote:
mrtmeo wrote:Hi Antonio,
Does your brother have kidney issues or normal GFR?
All the tests show that his kidneys are fine.

He never had kidney problems.
Why was his PTH so high?
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
AntonioBR
Family Elder
Posts: 607
Joined: Sat Dec 12, 2015 11:06 am

Re: My Brother's Condition (update)

Post by AntonioBR »

mrtmeo wrote:Why was his PTH so high?

Because he has a very high resistance (Th17) to vitamin D.

In a nutshell, second Coimbra this ''resistance'' seems to underlie the predisposition to (and maintenance of) autoimmune aggression through the Th17 program of activities. Th17 reaction is caused by overproduction of an "immune messenger" (cytokine) called "interleukin 17". Production of interleukin 17 is a natural phenomenon and is beneficial in adequate, regulated amounts. However, overproduction of interleukin 17 is not a natural phenomenon. And vitamin D regulates this interleukin 17 production. [1] [2]

So autoimmune disease is the result of a dysregulated immune system that produces an aberrant immunological Th17 reaction. And Vitamin D is the substance needed to regulate the immune system. As the protocol aims at regulating the immune system, it has been similarly effective in treating several other autoimmune diseases.


There are a lot of studies about it. I'm quoting only 2 of them.

[1] https://www.ncbi.nlm.nih.gov/pubmed/20974859
[2] http://www.frontiersin.org/10.3389/conf ... t_abstract
mrtmeo
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Posts: 121
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Location: Wisconsin, USA

Re: My Brother's Condition (update)

Post by mrtmeo »

AntonioBR wrote:
mrtmeo wrote:Why was his PTH so high?

Because he has a very high resistance (Th17) to vitamin D.

In a nutshell, second Coimbra this ''resistance'' seems to underlie the predisposition to (and maintenance of) autoimmune aggression through the Th17 program of activities. Th17 reaction is caused by overproduction of an "immune messenger" (cytokine) called "interleukin 17". Production of interleukin 17 is a natural phenomenon and is beneficial in adequate, regulated amounts. However, overproduction of interleukin 17 is not a natural phenomenon. And vitamin D regulates this interleukin 17 production. [1] [2]

So autoimmune disease is the result of a dysregulated immune system that produces an aberrant immunological Th17 reaction. And Vitamin D is the substance needed to regulate the immune system. As the protocol aims at regulating the immune system, it has been similarly effective in treating several other autoimmune diseases.


There are a lot of studies about it. I'm quoting only 2 of them.

[1] https://www.ncbi.nlm.nih.gov/pubmed/20974859
[2] http://www.frontiersin.org/10.3389/conf ... t_abstract
I have seen Th17 implicated in all the AI diseases I have looked at so far.
I wonder if it is in all AI diseases?
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
AntonioBR
Family Elder
Posts: 607
Joined: Sat Dec 12, 2015 11:06 am

Re: My Brother's Condition (update)

Post by AntonioBR »

mrtmeo wrote: I have seen Th17 implicated in all the AI diseases I have looked at so far.
I wonder if it is in all AI diseases?

Coimbra talks about Th17 and the correlation between autoimmune diseases on his interview for some German doctors: http://www.thisisms.com/forum/coimbra-h ... 28811.html
mrtmeo
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Posts: 121
Joined: Sun Aug 28, 2016 4:44 pm
Location: Wisconsin, USA

Re: My Brother's Condition (update)

Post by mrtmeo »

I know you posted your brothers PTH before treatment, but I can't find it anywhere.
Can you post it again?
Also, did your brother improve before the PTH came down to low normal or after?
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
AntonioBR
Family Elder
Posts: 607
Joined: Sat Dec 12, 2015 11:06 am

Re: My Brother's Condition (update)

Post by AntonioBR »

mrtmeo wrote:I know you posted your brothers PTH before treatment, but I can't find it anywhere.
Can you post it again?
Also, did your brother improve before the PTH came down to low normal or after?
On his first PTH test, it was at 85pg/mL.

The lab references was 11.0 pg/mL (minimum range) to 65.0 pg/mL (maximum range).

Before the test, he was taking 15,000IU's of D3 for one month. His PTH was so high that even taking this dose of 15k (considered highly toxic for FDA) his levels was 20.0 pg/mL higher than the maximum range.


After the first PTH test. The lab changed the references.

New Lab references: 7.50 to 53.50 pg/mL.

On his last test his PTH was at 6.90 pg/mL

Yes, he got better when his PTH achieve the minimum range. However, I agree that he is not the best subject to analyze about it, because when he had his second relapse (on April 2016 - his PTH was at 28,00 pg/mL) I searched for more options that could help him.

Even with the information that a relapse could happen until the PTH was not normalized (I mean at the low level), we were afraid. Then we have added LDN, Ozone and other things that I have described in the first posts of this thread.
Last edited by AntonioBR on Fri Mar 17, 2017 6:49 pm, edited 1 time in total.
mrtmeo
Family Elder
Posts: 121
Joined: Sun Aug 28, 2016 4:44 pm
Location: Wisconsin, USA

Re: My Brother's Condition (update)

Post by mrtmeo »

Wow, your brother's case is a very interesting one.
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
mrtmeo
Family Elder
Posts: 121
Joined: Sun Aug 28, 2016 4:44 pm
Location: Wisconsin, USA

Re: My Brother's Condition (update)

Post by mrtmeo »

Did it take 1 year, 3 months for your brothers disease to stop completely or while on the 180,000 iu per day dose?
How long did it take for him to see improvements?
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
AntonioBR
Family Elder
Posts: 607
Joined: Sat Dec 12, 2015 11:06 am

Re: My Brother's Condition (update)

Post by AntonioBR »

mrtmeo wrote:Did it take 1 year, 3 months for your brothers disease to stop completely or while on the 180,000 iu per day dose?
How long did it take for him to see improvements?
A quickly summary:

He started the protocol with 130,000IU/d3 then a relapse happened almost one month after. (vitamin D takes at least 3 months to change [modulate] your immune system).

The doctor increased his dose to 180k/d3.

Then, after 3 months he begun to see improvements in his leg coordination and vision.

After a while, probably because of a lot of stress (master's degree course) he had a relapse when he was taking 180k. Then the doctor increased it again to 250k. His PTH was at 28 pg/mL and the low level range is 7.50 pg/mL

Remembering that the doctor did not increase the dose necessarily because of the relapses. The first factor to be taken into consideration is your PTH level.

So, taking 250k for almost 4 months his PTH reached the minimum range. Finally. He saw more improvements: his legs are 100% again and the vision is much better.
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