Vitamin D resistance
Vitamin D resistance
Is the goal with the vitamin D protocol to overcome resistance of 25 hydroxy D (storage D) conversion to 1,25 dihydroxy D (active D) or is it resistance on a cellular level?
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
Re: Vitamin D resistance
Well, the resistance happens in a genetic level.mrtmeo wrote:Is the goal with the vitamin D protocol to overcome resistance of 25 hydroxy D (storage D) conversion to 1,25 dihydroxy D (active D) or is it resistance on a cellular level?
By genetic mutations, alteration of the genetic code itself... Or/and changes caused by modification of gene expression (epigenetic factor).
The exact mechanism of this resistance is not clear yet.
Second Coimbra the resistance may also be due to an alteration of the enzymes dealing with the conversion and activation of vitamin D, which are two hydroxylases. So there are many different possibilities. The effect of such genetically altered vitamin D metabolism happens on several diseases - not only autoimmune disorders.
The epigenetic hypothesis for some diseases seems very interesting and very plausible.
Re: Vitamin D resistance
I guess I am looking at it from the perspective of if the acitve D form never gets high enuf no matter how much D the person takes, will this keep the person from obtaining remission or is it problem with VDRs themselves?
Yes, epigenitics explains it all how our environment has everything to do with our gene expressions.
Yes, epigenitics explains it all how our environment has everything to do with our gene expressions.
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
Re: Vitamin D resistance
It happens with both healthy people and those who have autoimmune diseases. The 1,25-vitamin D form ''almost'' does not change even if you take high doses of vit.D.mrtmeo wrote:I guess I am looking at it from the perspective of if the acitve D form never gets high enuf no matter how much D the person takes, will this keep the person from obtaining remission or is it problem with VDRs themselves?
It is related with VDRs. And PTH - until now - it is the better form to measure it.
By the way talking about epigenetics there is a study published in march 29, 2017
Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis: http://journals.plos.org/plosone/articl ... ne.0174726