Statins have detrimental effects on remyelination in MS
Statins have detrimental effects on remyelination in MS
Simvastatin interferes with process outgrowth and branching of oligodendrocytes.
Abstract
Statins have attracted interest as a treatment option for multiple sclerosis (MS) because of their pleiotropic antiinflammatory and immunomodulatory effects.
However, contradictory results have been described when they are applied to oligodendrocytes (OLGs), the cell type predominantly affected in MS. In this study we focus on the in vitro effect of statins on process outgrowth in OLN-93 cells, a well-characterized OLG-derived cell line, and primary cultures of neonatal rat OLGs. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1319
MS-UK - http://www.ms-uk.org/
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 2478 Views
-
Last post by NHE
-
- 1 Replies
- 5625 Views
-
Last post by ElliotB
-
- 0 Replies
- 1317 Views
-
Last post by jimmylegs
-
- 0 Replies
- 1103 Views
-
Last post by frodo
-
- 0 Replies
- 1284 Views
-
Last post by DIM
-
- 0 Replies
- 1149 Views
-
Last post by frodo
-
- 0 Replies
- 1296 Views
-
Last post by NHE
-
- 1 Replies
- 3139 Views
-
Last post by Tif
-
- 0 Replies
- 1509 Views
-
Last post by DIM