On June 28, 2023 the prestigeous BMJ published a study titled « Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis » which was undertaken by a scientific team associated with theDepartment of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
« Objectives: Numerous studies have indicated that chronic cerebrospinal venous insufficiency is a potential factor in causing multiple sclerosis in recent years, but this conclusion remains unconfirmed. This meta-analysis examined the correlation between multiple sclerosis and chronic cerebrospinal venous insufficiency.
Methods: We searched Embase and Medline (Ovid) for publications published from 1 January 2006 to 1 May 2022. The meta-analysis was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results: Eligible studies (n=20) included 3069 participants from seven countries. Pooled analysis indicated that chronic cerebrospinal venous insufficiency was more frequent in patients with multiple sclerosis than in healthy controls (OR 3.36; 95% CI 1.92 to 5.85; p<0.001) with remarkable heterogeneity among studies (I2=79%). Results were more strongly correlated in subsequent sensitivity analyses, but heterogeneity was also more substantial. We removed studies that initially proposed a chronic cerebrospinal venous insufficiency team as well as studies by authors involved in or advocating endovascular therapies.
Conclusions: Chronic cerebrospinal venous insufficiency is significantly associated with multiple sclerosis and it is more prevalent in patients with multiple sclerosis than in healthy individuals, but considerable heterogeneity of results is still observed. »
Yes, while blood flow matters in the Multiple Sclerosis pathology, the origin of the obstructed blood/CSF flow circulation varies (heterogeneity) as will the treatment options.
So let’s consider another aspect of this conundrum.
Dr Zamboni holds that MS is an endothelial disease. So too Covid 19 disease. Covid 19 begins as a respiratory illness which eventually damages the endothelium of
blood vessels leading to many complications.
Let’s consider MS. The MS expert Neurologist Dr Zivadinov has determined that 4 factors characterize MS patients. One of those factors is a history of Mononucleosis caused by the Epstein Barr Virus (EBV). Not everyone carrying the EBV (95%) develops MS.
Lets look at this article :
« Interventional News
https://interventionalnews.com/brave-d…
Brave Dreams trial finds venous angioplasty “safe, but …Web20 nov. 2017
Although CCSVI is thought to be associated with cerebral venous abnormalities, the aetiology of cerebral venous abnormalities and the possible pathophysiological link to MS and other neurological disorders remain unclear. Several studies have suggested that, in the setting of venous flow abnormalities, this potential association is related to the accumulation of leucocytes in the vasculature. »
Question. Does Mononucleosis in particular promote this accumulation of leucocytes in the vasculature ?
Previously posted on my site mscureenigmas.net
mscureenigmas.net
https://www.mscureenigmas.net
How much does Leucocyte obstruction matter?
Re: How much does Leucocyte obstruction matter?
by vesta » Thu Jan 18, 2024 11:18 am
On June 28, 2023 the prestigeous BMJ published a study titled « Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis » which was undertaken by a scientific team associated with theDepartment of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
« Objectives: Numerous studies have indicated that chronic cerebrospinal venous insufficiency is a potential factor in causing multiple sclerosis in recent years, but this conclusion remains unconfirmed. This meta-analysis examined the correlation between multiple sclerosis and chronic cerebrospinal venous insufficiency.
Methods: We searched Embase and Medline (Ovid) for publications published from 1 January 2006 to 1 May 2022. The meta-analysis was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results: Eligible studies (n=20) included 3069 participants from seven countries. Pooled analysis indicated that chronic cerebrospinal venous insufficiency was more frequent in patients with multiple sclerosis than in healthy controls (OR 3.36; 95% CI 1.92 to 5.85; p<0.001) with remarkable heterogeneity among studies (I2=79%). Results were more strongly correlated in subsequent sensitivity analyses, but heterogeneity was also more substantial. We removed studies that initially proposed a chronic cerebrospinal venous insufficiency team as well as studies by authors involved in or advocating endovascular therapies.
Conclusions: Chronic cerebrospinal venous insufficiency is significantly associated with multiple sclerosis and it is more prevalent in patients with multiple sclerosis than in healthy individuals, but considerable heterogeneity of results is still observed. »
Yes, while blood flow matters in the Multiple Sclerosis pathology, the origin of the obstructed blood/CSF flow circulation varies (heterogeneity) as will the treatment options.
So let’s consider another aspect of this conundrum.
Dr Zamboni holds that MS is an endothelial disease. So too Covid 19 disease. Covid 19 begins as a respiratory illness which eventually damages the endothelium of
blood vessels leading to many complications.
Let’s consider MS. The MS expert Neurologist Dr Zivadinov has determined that 4 factors characterize MS patients. One of those factors is a history of Mononucleosis caused by the Epstein Barr Virus (EBV). Not everyone carrying the EBV (95%) develops MS.
Lets look at this article :
« Interventional News
https://interventionalnews.com/brave-d…
Brave Dreams trial finds venous angioplasty “safe, but …Web20 nov. 2017
Although CCSVI is thought to be associated with cerebral venous abnormalities, the aetiology of cerebral venous abnormalities and the possible pathophysiological link to MS and other neurological disorders remain unclear. Several studies have suggested that, in the setting of venous flow abnormalities, this potential association is related to the accumulation of leucocytes in the vasculature. »
Question. Does Mononucleosis in particular promote this accumulation of leucocytes in the vasculature ?
Previously posted on my site mscureenigmas.net
mscureenigmas.net
https://www.mscureenigmas.net
On June 28, 2023 the prestigeous BMJ published a study titled « Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis » which was undertaken by a scientific team associated with theDepartment of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
« Objectives: Numerous studies have indicated that chronic cerebrospinal venous insufficiency is a potential factor in causing multiple sclerosis in recent years, but this conclusion remains unconfirmed. This meta-analysis examined the correlation between multiple sclerosis and chronic cerebrospinal venous insufficiency.
Methods: We searched Embase and Medline (Ovid) for publications published from 1 January 2006 to 1 May 2022. The meta-analysis was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results: Eligible studies (n=20) included 3069 participants from seven countries. Pooled analysis indicated that chronic cerebrospinal venous insufficiency was more frequent in patients with multiple sclerosis than in healthy controls (OR 3.36; 95% CI 1.92 to 5.85; p<0.001) with remarkable heterogeneity among studies (I2=79%). Results were more strongly correlated in subsequent sensitivity analyses, but heterogeneity was also more substantial. We removed studies that initially proposed a chronic cerebrospinal venous insufficiency team as well as studies by authors involved in or advocating endovascular therapies.
Conclusions: Chronic cerebrospinal venous insufficiency is significantly associated with multiple sclerosis and it is more prevalent in patients with multiple sclerosis than in healthy individuals, but considerable heterogeneity of results is still observed. »
Yes, while blood flow matters in the Multiple Sclerosis pathology, the origin of the obstructed blood/CSF flow circulation varies (heterogeneity) as will the treatment options.
So let’s consider another aspect of this conundrum.
Dr Zamboni holds that MS is an endothelial disease. So too Covid 19 disease. Covid 19 begins as a respiratory illness which eventually damages the endothelium of
blood vessels leading to many complications.
Let’s consider MS. The MS expert Neurologist Dr Zivadinov has determined that 4 factors characterize MS patients. One of those factors is a history of Mononucleosis caused by the Epstein Barr Virus (EBV). Not everyone carrying the EBV (95%) develops MS.
Lets look at this article :
« Interventional News
https://interventionalnews.com/brave-d…
Brave Dreams trial finds venous angioplasty “safe, but …Web20 nov. 2017
Although CCSVI is thought to be associated with cerebral venous abnormalities, the aetiology of cerebral venous abnormalities and the possible pathophysiological link to MS and other neurological disorders remain unclear. Several studies have suggested that, in the setting of venous flow abnormalities, this potential association is related to the accumulation of leucocytes in the vasculature. »
Question. Does Mononucleosis in particular promote this accumulation of leucocytes in the vasculature ?
Previously posted on my site mscureenigmas.net
mscureenigmas.net
https://www.mscureenigmas.net
Re: How much does Leucocyte obstruction matter?
Just for the record I got Mononucleosis in my 60's. About 20 years after the start of PPMS.
Re: How much does Leucocyte obstruction matter?
My wife had repetitive EBV infections just before the onset of her MS and increased antigens in her last very bad relapse four years ago that left her gait, balance, and fatigue problems!
Re: How much does Leucocyte obstruction matter?
Actually, Dr. Zamboni felt this was true but later updated his view on this concept a number of years ago that that MS is NOT an endothelial disease."Dr Zamboni holds that MS is an endothelial disease."
Re: How much does Leucocyte obstruction matter?
Greetings:
If it's not an endothelial disease, How does Dr Zamboni define it??
In the case of MS it might be appropriate to say it is sometimes a disease of the endothelium which obstructs fluid flow.
"Wikipedia
https://en.wikipedia.org/wiki/Endothelium
Endothelium - Wikipedia
OverviewStructureFunctionClinical significanceHistorySee alsoExternal links
The endothelium (pl.: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. Endothelial cells form the barrier between vessels and tissue and control the flow of substances and fluid into and out of …
icône du web mondia
Best Regards, Vesta
If it's not an endothelial disease, How does Dr Zamboni define it??
In the case of MS it might be appropriate to say it is sometimes a disease of the endothelium which obstructs fluid flow.
"Wikipedia
https://en.wikipedia.org/wiki/Endothelium
Endothelium - Wikipedia
OverviewStructureFunctionClinical significanceHistorySee alsoExternal links
The endothelium (pl.: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. Endothelial cells form the barrier between vessels and tissue and control the flow of substances and fluid into and out of …
icône du web mondia
Best Regards, Vesta
Re: How much does Leucocyte obstruction matter?
I don't believe he has ever redefined it.How does Dr Zamboni define it??
This 'conclusion' speaks volumes:
An interesting conclusion YET I believe not everyone with MS has CCSVI, it appears this statement implies this and I believe that not everyone with CCSVI develops MS. IF someone has evidence showing otherwise, please post it.Conclusions: Chronic cerebrospinal venous insufficiency is significantly associated with multiple sclerosis, and it is more prevalent in patients with multiple sclerosis than in healthy individuals.
MORE Prevalent.. Hmmmm If CCSVI was THE cause of MS, wouldn't everyone who has MS have this condition and wouldn't everyone with this condition eventually get MS?
Re: How much does Leucocyte obstruction matter?
It might be more helpful to speak of Association between poor fluid circulation impacting the CNS and MS. I think Dr Owiesy's observation that when the muscle layer of the vein is stressed, it goes into spasm, blood circulation is impeded. This could explain the impact of allergy for example.
It may be that disruption of ANY fluid bathing the central nervous system (blood, cerebro-spinal, lymphatic, glymphatic) can cause “MS” symptoms.
Best regards, Vesta
It may be that disruption of ANY fluid bathing the central nervous system (blood, cerebro-spinal, lymphatic, glymphatic) can cause “MS” symptoms.
Best regards, Vesta
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