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Patterns: Plasmapheresis confirmed as selective treatment.

Posted: Wed Feb 28, 2018 4:34 am
by frodo
Plasmapheresis has been confirmed a second time as a selective treatment for patterns I and II. This has been consistently reported since 2005.

Tissue Markers for Acute Multiple Sclerosis Treatment Response—A Step Toward Personalized Medicine
JAMA neurology, February 5, 2018 and ... irect=true


Many of the same investigators involved in the original lesion pattern study applied their lesion classification schema to short-term response to treatment.

This retrospective study evaluated short-term clinical responses to apheresis (plasmapheresis), stratified by 3 of the 4 lesion patterns. Among those with T-cell mediated autoimmune pathology, 31% to 55% demonstrated functional response to apheresis.

Researchers suggested that T-cell mediated autoimmune pathology with antibody and complement activation (pattern 2) responded the best. None of the patients with oligodendrocytopathy (pattern 3) demonstrated improvement.

See also: ... c4567.html

and ... irect=true (Feb. 2018)

and ... irect=true (Feb. 2018)