reviewing.
re your earlier post
http://www.thisisms.com/forum/post249902.html#p249902
have you had bloodwork to rule out any of the considerations posted here?
http://www.thisisms.com/forum/undiagnos ... ml#p229973
also pls consider these baseline magnesium values
Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours-Potential Consequences for Monitoring and Supplementation (2017)
https://www.ncbi.nlm.nih.gov/pubmed/27997264
from the abstract:
"Both, iMg and tMg, returned to baseline, on average, 2.5 hr after exercise. These findings suggest that timing of blood sampling to analyze Mg status is important."
from full text:
Table 1 Participants’ Characteristics
...................................men...............women
Plasma tMg (mmol/L).....0.88 ± 0.03.....0.87 ± 0.08
so, per empirical rule this means at baseline 50% of male
athletes studied were below 0.88 mmol/l at baseline before exertion. a sucky low normal place to be.
also per empirical rule, 84% of male runners in the study were below 0.91 mmol/l (still low normal, consistent with ms patients).
typical for magnesium assessment: even at -3 SD (0.79 mmol/l) none of the male
athletes were technically deficient according to current poorly defined reference ranges. (eg in this study, "Their total plasma magnesium concentration was > 0.70 mmol/L (lower limit of normal)"
using this definition of the normal range for serum magnesium, outright magnesium deficiency status is only captured in female study participants, and for that matter only in 0.15% of those.
then "After exercise (12:30 p.m.), both total and ionized magnesium concentrations were significantly lower. Ionized magnesium decreased by 0.06 ± 0.03 mmol/L to 0.45 ± 0.03 mmol/L (p < .001). Total magnesium decreased by 0.08 ± 0.04 mmol/L to 0.73 ± 0.06 mmol/L (p < .001)."
sure, levels return to pre-exercise levels within a few hours post exertion. but if most of the group was not in a good place to start with, bears thinking about taking some corrective action.
if you use 0.95 mmol/l as the lower cutoff for serum mag, as has been suggested in literature, in men only the right tail of the bell curve, 0.15% are within the normal range at this study's baseline. some women better off, with 16% above 0.95 mmol/l at baseline.
re thrombois x vertigo x magnesium:
case studies only, also females not males, but still interesting
Pills and thrombosis: platelets, estrogens and magnesium (1970)
https://www.popline.org/node/475109
A 22-year-old woman with
3 episodes of thrombophlebitis in 2 years also had vertigo, headaches, anxiety, spasms and tetany. She had a positive Chvostek sign bilaterally,
low red blood cell magnesium of 45.5 and 50 mg per 1, abnormal EKG, electronystagmogram and electromyogram, Platelet hyperaggregability and ADP and adrenalin.
Magnesium lactate 3 gm
and pyridoxine 750 mg per day
normalized all these signs and she has been well for 2 years. The second case was a 44-year-old woman with suicidal depression, obsessed with her severe acne, which was being treated with 250 mcg ethinyl estradiol on Cycle Days 5-25. To rule out platelet hyperaggregability, she was subjected to electromyogram and hematologic workup. She had positive Chvostek sign, tetany,
low plasma magnesium of 16.4 mg per 1, low red cell magnesium of 46.7 mg per 1, and platelet hyperaggregability induced by ADP, collagen and adrenalin. With treatment of
oral magnesium lactate 3 gm per day the
platelet findings became normal.
re vertigo, nausea and magnesium:
Restoring electrolyte balance: magnesium (1996)
http://bit.ly/2nkg30t
Magnesium deficiency or hypomagnesemia is due to increased renal excretion caused by the use of loop diuretics or aminoglycosides. Symptoms include arrhythmias, ataxia and
vertigo, while treatments include the intake of magnesium-rich foods and oral magnesium supplements.
On the other hand, high magnesium levels or hypermagnesia is due to excessive intakes of magnesium-containing antacids and cathartics.
Symptoms include weakness,
nausea and vomiting, while treatment includes intravenously hydrating patients with magnesium-free fluids.
mag status might be worth looking into! thinking the nausea may be secondary to the vertigo, less likely a consequence of mag excess.
this kind of statement drives me nuts:
http://bit.ly/2i954ll
"Despite testimonials to magnesium therapy for vertigo on the Internet, there is
no solid medical evidence linking BPPV with magnesium deficiency or supporting magnesium therapy. Alternatively, there is growing evidence linking BPPV with bone loss and with low levels of vitamin D."
ummmmmmm but what about the association between mag and low d3? case study example of the available evidence linking low mag and low d3, albeit thin:
http://www.thisisms.com/forum/natural-a ... ml#p249333
"
Table 1. Electrolyte balance and other biochemical data at admittance, during and after magnesium supplements and esomeprazole
................................Normal value..........Day 1........6 months
Serum magnesium.....0.65-1.05 mmol/l.....0.18..........0.67
Serum vitamin D3.........30-130 nmol/l......39.............58"
might be time to address that lil vertigo/mag/d3 research gap, yea? could help a few ppl out. at least science is starting to get around to the mag/d3 connection! eg:
D3 might be screwing with magnesium status
Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? (2016)
http://www.thisisms.com/forum/natural-a ... ml#p245963
"Magnesium is a cofactor for vitamin D biosynthesis, transport, and activation; and vitamin D and magnesium studies both showed associations with several of the same chronic diseases. Research on possible magnesium and vitamin D interactions in these human diseases is currently rare. Interactions of low magnesium status with calcium and vitamin D, especially during supplementation, require further study."
yes. time to get on that.
and,
Magnesium Supplementation in Vitamin D Deficiency (2017)
https://www.ncbi.nlm.nih.gov/pubmed/28471760
"Screening for chronic magnesium deficiency is difficult because a normal serum level may still be associated with moderate to severe deficiency." (you don't say!!)
"Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy"