I wondered why HarryZ had gone quiet. It looks as if he is now working for the Sunday Mirror.
For non-UK citizens, NHS is the National Health Service - the health system in the UK which is funded by taxation and is free at the point of delivery.
http://c.moreover.com/click/here.pl?j623481147&w=464753
DMDs are crap
where is Harry?
Are you sure it is Harry or just someone brave enough to post the truth about the ABC's ?
gwa
gwa
Actually they're not saying that the interferons don't work (although we know their efficacy is hardly stellar). The point of the article is that up to 40% of patients develop NABs which then limit the efficacy. Currently the presence of NABs is not monitored and it should be.
Interestingly enough there is a new major study going on to assess the effects of NABs on interferon treatment. The kicker is that the study is being funded by Teva who don't produce an interferon but produce Copaxone.
More about commercial interests than patient interests methinks....
Robin
Interestingly enough there is a new major study going on to assess the effects of NABs on interferon treatment. The kicker is that the study is being funded by Teva who don't produce an interferon but produce Copaxone.
More about commercial interests than patient interests methinks....
Robin
Do not go gentle into that good night. Rage, rage against the dying of the light.
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HarryZ
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Re: DMDs are crap
Ian,
Seriously, the efficacy of the CRABs has been questioned for quite some time. One only needs to read Dr. Behan's Pathogenesis of MS from a few years ago to get a larger picture of how poor the cost/benefit situation is for these drugs. But as usual, good marketing and sales trumps science when it comes to the world of drugs, especially those involving MS.
As we all now know, Tysabri's makers are making a strong effort to take a large chunk of the CRAB's market share away. I doubt it will mean much benefit for MS patients but certainly interesting to follow the action on the "battlefields" as the big pharmas line up against one another!
Take care.
Harry
Hey, I tried to get a job with the Sunday Mirror but the UK government wouldn't issue me a working visabromley wrote:I wondered why HarryZ had gone quiet. It looks as if he is now working for the Sunday Mirror.
Seriously, the efficacy of the CRABs has been questioned for quite some time. One only needs to read Dr. Behan's Pathogenesis of MS from a few years ago to get a larger picture of how poor the cost/benefit situation is for these drugs. But as usual, good marketing and sales trumps science when it comes to the world of drugs, especially those involving MS.
As we all now know, Tysabri's makers are making a strong effort to take a large chunk of the CRAB's market share away. I doubt it will mean much benefit for MS patients but certainly interesting to follow the action on the "battlefields" as the big pharmas line up against one another!
Take care.
Harry
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thisiswater
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Re: DMDs are crap
Would someone explain these acronyms and ... what you are talking about to those of us in the states? Thanks in advance!
Re: DMDs are crap
Please see this list in the Forums FAQ for an explanation of many of the commonly used acronyms on ThisIsMS.thisiswater wrote:Would someone explain these acronyms and ... what you are talking about to those of us in the states? Thanks in advance!
http://www.thisisms.com/forum/site-supp ... ml#p210825
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euphoniaa
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Re: DMDs are crap
Also, heads up to thisiswater...
This thread you bumped is from 2006, 10 years ago, way before several of the new oral meds had arrived on the scene.
The original posters are mainly talking about the earlier, injectible DMDs, the interferons (Avonex, Rebif, Betaseron) and Copaxone (glatiramer acetate) often referred to as the CRAB meds for their first initials.
Also, Tysabri had just been approved in 2004, taken off the market due to the potential side effect of death in early 2005, and had likely just returned. Those were our only mainstream DMD choices at that time (plus some used the chemo med Novantrone).
The new oral DMDs, although seemingly more user friendly than giving yourself shots for years, haven't been in use long enough to have a really good record outside of the trials yet. In my humble, completely med-phobic opinion. However, I've still never tried any prescription drug for MS or MS symptoms, so I have no personal experience either.
DMD: Disease Modifying Drug
This thread you bumped is from 2006, 10 years ago, way before several of the new oral meds had arrived on the scene.
The original posters are mainly talking about the earlier, injectible DMDs, the interferons (Avonex, Rebif, Betaseron) and Copaxone (glatiramer acetate) often referred to as the CRAB meds for their first initials.Also, Tysabri had just been approved in 2004, taken off the market due to the potential side effect of death in early 2005, and had likely just returned. Those were our only mainstream DMD choices at that time (plus some used the chemo med Novantrone).
The new oral DMDs, although seemingly more user friendly than giving yourself shots for years, haven't been in use long enough to have a really good record outside of the trials yet. In my humble, completely med-phobic opinion.
However, I've still never tried any prescription drug for MS or MS symptoms, so I have no personal experience either.DMD: Disease Modifying Drug
Dx'd with MS & HNPP (hereditary peripheral neuropathy) 7/03 but must have had MS for 30 yrs before that. I've never taken meds for MS except 1 yr experiment on LDN. (I found diet, exercise, sleep, humor, music help me the most.)