This Is MS Multiple Sclerosis Knowledge & Support Community

2018 Oct 8
University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK
From Nose to Gut - The Role of the Microbiome in Neurological Disease
https://www.ncbi.nlm.nih.gov/pubmed/30298527

Abstract
Inflammation and neurodegeneration are key features of many chronic neurological diseases, yet the causative mechanisms underlying these processes are poorly understood. There has been mounting interest in the role of the human microbiome in modulating the inflammatory milieu of the central nervous system in health and disease. To date, most research has focussed on a gut-brain axis, with other mucosal surfaces being relatively neglected. We herein take the novel approach of comprehensively reviewing the roles of the microbiome across several key mucosal interfaces - the nose, mouth, lung, and gut - in health and in Parkinson's disease (PD), Alzheimer's disease (AD) and multiple sclerosis ..

quote from the abstract: The cumulative effects of dysbiosis from the nose to the gut may contribute significantly to neurological disease through a wide variety of mechanisms, including direct translocation of bacteria and their products, and modulation of systemic or central nervous system-specific immunity. unquote

Of course. Weakened immunity of the nasopharynx (CCSVI may be a contributing factor here) leads to herpes viral spreading. This may initiate a long cascade of events that eventually leads to inflammatory and -later on- to progressive MS. This is yet another publication that fully fits the skeleton at http://www.thisisms.com/forum/general-d ... ml#p251748 (see e.g. step 2 viral culprit where hypoperfusion weakens the immunity of the nasopharynx)