Mitochondrial Transplantation
Posted: Sun Feb 27, 2022 8:21 am
2022 Feb 17
Istituto per la Ricerca e l'Innovazione Biomedica, CNR, Palermo, Italy
Promising Treatment for Multiple Sclerosis: Mitochondrial Transplantation
https://pubmed.ncbi.nlm.nih.gov/35216361/
Abstract
In recent years, several studies have examined the multifaceted role of mitochondria in Multiple Sclerosis (MS), suggesting that, besides inflammation and demyelination, mitochondrial aberration is a crucial factor in mediating axonal degeneration, the latter being responsible for persistent disabilities in MS patients. Therefore, mitochondria have been recognized as a possible multiple sclerosis therapeutic target. Recently, mitochondrial transplantation has become a new term for the transfer of live mitochondria into damaged cells for the treatment of various diseases, including neurodegenerative diseases. In this hypothesis, we propose mitochondrial transplantation as a new, potentially applicable approach to counteract axonal degeneration in multiple sclerosis.
Istituto per la Ricerca e l'Innovazione Biomedica, CNR, Palermo, Italy
Promising Treatment for Multiple Sclerosis: Mitochondrial Transplantation
https://pubmed.ncbi.nlm.nih.gov/35216361/
Abstract
In recent years, several studies have examined the multifaceted role of mitochondria in Multiple Sclerosis (MS), suggesting that, besides inflammation and demyelination, mitochondrial aberration is a crucial factor in mediating axonal degeneration, the latter being responsible for persistent disabilities in MS patients. Therefore, mitochondria have been recognized as a possible multiple sclerosis therapeutic target. Recently, mitochondrial transplantation has become a new term for the transfer of live mitochondria into damaged cells for the treatment of various diseases, including neurodegenerative diseases. In this hypothesis, we propose mitochondrial transplantation as a new, potentially applicable approach to counteract axonal degeneration in multiple sclerosis.