This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Wed Jun 19, 2013 6:00 am


All times are UTC - 8 hours [ DST ]




Post new topic Reply to topic  [ 5 posts ] 
Author Message
PostPosted: Tue Jun 07, 2011 3:14 pm 
Offline
Family Elder
User avatar

Joined: Wed Dec 02, 2009 4:00 pm
Posts: 532
NAWM (normal appearing white matter) is the name for abnormal white matter areas that look normal in MRI, but under special MRIs are abnormal. They are important because MS lesions appear inside these NAWM areas, and therefore they represent an early problem before developing the lesions.

As anybody here would have bet, they are connected with blood flow, more exactly, with cerebral small vessel disease (SVD) :

Diffusion tensor imaging and cognition in cerebral small vessel disease
http://www.ncbi.nlm.nih.gov/pubmed/21549191

CONCLUSION: DTI parameters in both WML and NAWM correlate with cognitive performance, independent of SVD. DTI may be a promising tool in exploring the mechanisms of cognitive decline and could function as a surrogate marker for disease progression in therapeutic trials. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.

_________________
You can get a worldwide list of available sites for CCSVI at http://www.ccsviclinic.info


Top
 Profile  
 
 Post subject:
PostPosted: Tue Jun 07, 2011 3:22 pm 
Offline
Family Elder

Joined: Mon Jan 04, 2010 4:00 pm
Posts: 8554
In EAE, the mice do not develop NAWM, so this is unexplained by autoimmune theory but explained by CCSVI theory.

Very interesting!


Top
 Profile  
 
 Post subject:
PostPosted: Tue Jun 07, 2011 10:32 pm 
Offline
Family Elder
User avatar

Joined: Wed Mar 17, 2010 4:00 pm
Posts: 2602
Location: Kanata, Ontario, Canada
I do not think EAE is a very good or comprehensive model of all autoimmune disease or theory. In fact I don't even know much about why it's thought to model autoimmunity at all.

_________________
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience


Top
 Profile  
 
 Post subject:
PostPosted: Wed Jun 08, 2011 12:11 am 
Offline
Family Elder
User avatar

Joined: Tue Dec 01, 2009 4:00 pm
Posts: 979
Location: Ucluluet, BC
Dateline: Vancouver
March 1993

Today, at the offices of Western Canada's pre-eminent neurologist, a young man of 31 years had the audacity to refuse the new, experimental betaSerone injections; stating "I don't believe that my immune system is attacking my central nervous system (CNS)", "You don't know what causes it ("Multiple Sclerosis"), have never cured anyone, don't know the long-term benefits or risks of the drugs..."

-----------------------------------------------------------------------------------------

18 years later, congenital venous malformations of the IJVs and azygous vein are identified by IVUS, and treated. These CVMs were not caused by the immune system, and are not treatable by any known DMDs (disease modifying drugs).

Conclusion: "MS" is not an auto-immune disease, in my experience. I believe that it is congenitally compromised cerebral venous outflow in conjunction with exogenous factors - such as; bacterial infection, environmental insult, iatrogenic insult (vaccines, etc.).

Bottom line: no one knows still, what causes "MS", but there is a lot more pointing toward vasculature than a rogue immune system.

_________________
My name is not really Johnson. MSed up since 1993


Top
 Profile  
 
 Post subject:
PostPosted: Thu Jun 09, 2011 12:25 am 
Offline
Family Elder
User avatar

Joined: Wed Dec 02, 2009 4:00 pm
Posts: 532
By the way, related to this, NAWM also presents hypoperfusion, and that is previous to axonal loss and BBB breakdown.

Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance

http://www.ncbi.nlm.nih.gov/pubmed/18594554

And it would be funny to hear the supporters of the "only-autoimmune" theory explaining this.

_________________
You can get a worldwide list of available sites for CCSVI at http://www.ccsviclinic.info


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 5 posts ] 

All times are UTC - 8 hours [ DST ]


Related topics
 Topics   Author   Replies   Views   Last post 
There are no new unread posts for this topic. PARKINSON'S DISEASE BLOOD VESSEL ABNORMALITY

dania

1

618

Tue Sep 13, 2011 6:27 pm

1eye View the latest post

There are no new unread posts for this topic. Bionic Blood Vessel

PointsNorth

0

116

Thu Jun 13, 2013 6:14 pm

PointsNorth View the latest post

There are no new unread posts for this topic. ON THE VESSEL-PLAQUE RELATIONSHIPS IN THE BRAIN IN MULTIPLE

sbr487

3

897

Tue Sep 21, 2010 2:26 pm

fernando View the latest post

There are no new unread posts for this topic. blood vessel pathology suggested in sepsis

[ Go to pageGo to page: 1, 2 ]

Frank

25

2075

Wed Jun 29, 2011 7:40 pm

Shannon View the latest post

There are no new unread posts for this topic. Olive Oil May Boost Blood Vessel Function

dania

10

628

Sun Sep 09, 2012 8:52 pm

drsclafani View the latest post

 


Who is online

Users browsing this forum: tonya


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to:  


News News Site map Site map SitemapIndex SitemapIndex RSS Feed RSS Feed Channel list Channel list
Read hundreds of personal Multiple Sclerosis stories on Experience Project. Experience Project is an anonymous community where people connect through their life experiences, made by the same people who built This is MS. With over 30 million personal stories about every possible life experience, you can quickly find people like you!


Interesting: Secret Confessions | Dream Meanings | Ask Questions, Get Answers

Advertise on the premier multiple sclerosis forum