Picamilon - Niacin for the brain (ie Vasodilator)

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Picamilon - Niacin for the brain (ie Vasodilator)

Postby CureOrBust » Wed Nov 28, 2012 3:16 am

I haven't looked into it too far at this stage, but after stumbling across it, the links are looking interesting.

Picamilon is able to cross the blood–brain barrier[5] and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response.[6] The second released component, niacin acts as a strong vasodilator,[7] which might be useful for the treatment of migraine headaches.[8][9]

http://www.calmclinic.com/anxiety/drugs/picamilon This one is mostly on anxiety
...Taken on its own, Niacin is a water-soluble B vitamin that easily crosses the blood-brain barrier. It functions to protect neurons against the effects of diminished blood flow...Because this drug can easily penetrate the blood-brain barrier,improve brain blood flow ...

http://smart-drugs.net/info-picamilon.htm Here they are trying to sell the stuff
...Studies show that Picamilon dramatically increases blood flow and circulation within the brain...Picamilon increases blood supply and functional state of the brain, increases microcirculation and hemodynamics of the eyes... and vasoactive agent for acute ischemic disturbances of the cerebral blood circulation of mild to moderate severity...In opthalmological practice, for primary open-angle glaucoma with normalized intraocular pressure, and for diseases of the retina and the optic nerve....

It was also mentioned in another post on this web site by "search" at http://www.thisisms.com/forum/general-discussion-f1/topic19557-30.html#p189474

Anyone have any personal experience to share?
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Postby CaliReader » Thu Jan 03, 2013 3:29 pm

No personal experience yet, but I'm going to add this supplement.

It crosses the blood brain barrier and calms inflammation in the brain.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823917/ full text available. Proc Natl Acad Sci U S A >v.107(6); Feb 9, 2010 >PMC2823917
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Postby PointsNorth » Thu Jan 03, 2013 4:42 pm

Albany 2010. Brooklyn 2011
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Coimbra Protocol 2014-16
DrG B12 Transdermal Spray 2014-16
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My Current Regimen http://www.thisisms.com/forum/regimens-f22/topic25634.html
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Postby daniel » Fri Aug 09, 2013 7:53 am

Anyone notice any results so far from Picamilon? (And if so, at what dosages?)
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Postby ConstableComfortable » Thu Aug 15, 2013 9:55 am

I've taken Picamilon(100mg 'Mind Nutrition' brand) a few times before sleep and found it did act as a relaxant. I was a little fluffy the next morning for an hour or so too. The blurb on the side says to take 1 'for a calm relaxed feeling' and to take '2-3 to increase mental energy'. How that works I'm not sure and have not tested the increased dosage out.
I don't have any major MS symptoms as yet (diagnosed RRMS 5 years ago - I was just hoping for a good nights sleep. Can't say it was a better nights sleep but will try again in the future
I go for NUCCA adjustments every couple of months and the times I tried it I'm sure my atlas (C1) was out so could have not worked as fully or as it should have?? I've just been adjusted so maybe I'll try one soon and compare.
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Postby 1eye » Thu Aug 15, 2013 10:13 am

Lowers Blood Pressure

The effect of Picamilon on cerebral blood flow was compared with that of papaverine and complamin. The scientists found that Picamilon had a stronger blood pressure-lowering effect than papaverine; complamin mainly affects the peripheral circulation, and it exhibits neither tranquilizing nor stimulating properties.

Picamilon is an approved drug in Russia. It is intended for use in adults as a vasoactive (effecting the caliber of blood vessels) and nootropic (benefiting cognition and nerves) agent for acute cerebrovascular disturbances of mild severity, chronic cerebrovascular insufficiency, and vegetovascular dystonia (an imbalance between sympathetic and parasympathetic influences on vascular tone). The drug is indicated as a tranquilizer for states of anxiety, fear, increased irritability and emotional stress. Picamilon is recommended for depressive disorders in the elderly and for senile psychoses. In management of drug addictions, the compound can be used to abolish withdrawal symptoms in chronic alcoholics. Picamilon is supplied in 0.01, 0.02, and 0.05 gram tablets. It has a useful shelf life of three years.

This is good to know as it may combine with ED drugs or nitroglycerine and cause heart trouble.
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