patientx wrote:I'd say at this point it proves that the true indicator of disability is Iron buildup, not the lesions in the white matter.
I think you have to be careful here. True, white matter lesions are not a good indicator of disability. But the studies done by Haacke are far from proof that iron buildup is the true indicator of disability. The main purpose of his study was to show that his new filtering and signal processing could more sensitively detect iron in tissue. From his paper:The amount of iron deposition could reflect the extent of tissue damage, thus iron could be used as a biomarker to predict clinical outcome. This is a reasonable hypothesis given recent findings (27), which show very clear iron deposition encircling dilated veins in MS.
And the researchers can't say definitively where the iron comes from:The source of iron deposition may be myelin/oligodendrocyte debris (17), concentrated iron in the macrophages (that phagocytize the destructed myelin/oligodendrocyte), or the product of hemorrhages from damaged brain vessels.
Iron deposition probably will turn out to be a useful biomarker in MS. But, to my knowledge, only one study has been done to try and correlate possible iron buildup with clinical status. Much more study needs to be done before we can say there is proof.
Rebecca wrote:After watching the "MS business" for so many years, I am somewhat cynical with respect to the motives of those selling treatments for MS. While CCSVI surgery may turn out to make sense, there are a couple of things that make me skeptical. Please let me know what you think of these.
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