YES a systematic review from 2016 that saved me some time lolChu, A., Petocz, P., & Samman, S. (2017). Plasma/Serum Zinc Status During Aerobic Exercise Recovery: A Systematic Review and Meta-Analysis. Sports Medicine, 47(1), 127-134.
http://link.springer.com/article/10.100 ... 016-0567-0
"Females generally have lower serum zinc levels compared to males , which is driven by the different distribution of sex hormones as exemplifed by the interaction between the use of oral contraceptive agents and serum zinc concentrations."
next, selected articles through the years. have not checked refs for the above, just using a scant handful of top google scholar results roughly by decade. just wanted an idea of how far back the thinking goes.Dante, G., Vaiarelli, A., & Facchinetti, F. (2016). Vitamin and mineral needs during the oral contraceptive therapy: a systematic review. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 3(1), 1-10.
A decrease in the serum concentrations of zinc, selenium, phosphorus and magnesium have been reported in OC users. Such reductions were proportional to the duration of contraceptive use. These reductions may imply a reduction in the probability of having a pregnancy and/or an increase of serious illness for the unborn. In this regard, a supplementation with the above compounds could be useful in OC users, namely for reducing side effects.
wording suggests that 250 should be a 25. no full text for me on this one though. can't check. perils of scanning/text recognition/etcHalsted, J. A., Hackley, B. M., & Smith Jr, J. C. (1968). Plasma-zinc and copper in pregnancy and after oral contraceptives. Lancet, 2, 278-279.
"Zinc plasma-concentration diminished in those taking oral contraceptives from an average normal of 96 µg/dL to 69 µg/dL, and in the pregnant patients to 250 µg/dL."
Hess, F. M., King, J. C., & Margen, S. (1977). Effect of low zinc intake and oral contraceptive agents on nitrogen utilization and clinical findings in young women. J Nutr, 107(12), 2219-2227.
"Clinical problems developed in all the subjects with serum zinc levels below 50 µg/dL during the study; three of the six with serum zinc levels above 50 µg/dL also complained of clinical symptoms. The results suggest that zinc deficiency through depletion of accessible body zinc stores developed during the 35-day study."
so in this one, control group zinc copper ratio was 151/131 = 1.16:1, very close to healthy optimal 1.1:1. OCA group zinc to copper ratio ended up at 130/200 = 0.65:1. that's fine if you're talking copper:zinc ratio. not zinc:copper.Crews, M. G., Taper, L. J., & Ritchey, S. J. (1980). Effects of oral contraceptive agents on copper and zinc balance in young women. The American journal of clinical nutrition, 33(9), 1940-1945.
"Plasma concentrations of zinc were not different for the two groups (Table 5), but the plasma copper level was significantly higher
(F < 0.01) in the oral contraceptive users. The copper values are comparable with other reports (1, 3, 5). Plasma zinc concentrations
are in the range of other reports (3, 6, 9). Values in this study are in the upper range of reported concentrations and may reflect the
blood handling procedures used."
and now, for something where you can see the actual levels...Bredholt, M., & Frederiksen, J. L. (2016). Zinc in multiple sclerosis: a systematic review and meta-analysis. ASN neuro, 8(3), 1759091416651511.
http://journals.sagepub.com/doi/abs/10. ... 1416651511
"The result of the meta-analysis shows a reduction in serum or plasma Zn levels in patients with MS with a 95% CI of [−3.66, −0.93] and a p value of .001 for the difference in Zn concentration in μM."
note the completely inverted copper zinc ratios, bad for RRMS and TERRIBLE for SPMSGhazavi, A., Kianbakht, S., Ghasami, K., & Mosayebi, G. (2012). High copper and low zinc serum levels in Iranian patients with multiple sclerosis: a case control study. Clin Lab, 58(1-2), 161-164.
Zn level (µg/dL)...40.17 ±31.89a........23.12 ±10.59c.......42.06 ±32.94.......127.77 ±42.2
Cu level (µg/dL)..114.05 ±42b.........126.14 ±44.20.......111.22 ±39.45.........91.3 ±37
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