This article suggests the influence of testosterone on the health of endothelial cells and its vasodilatory effects: http://www.pnas.org/content/99/6/4055.full.pdf
A higher level of testosterone in the blood is probably associated with a lower risk of getting MS.
I think that it is this hormone that explains the difference between men and women, although obviously that is only one factor...
As regards the article in the above posting, although of course I don't agree with the EAE concept as such, my explanation here is that both for MS/impaired glucose metabolism and for EAE, the vasodilatory effects of testosterone improve the nutritional condition of cells in the endothelium/lymphatic system and hence provide nerve protection.
You may find a broader highly consistent picture on related issues on general-discussion-f1/topic15188-330.html