Bacterium Clostridium perfringens may be MS trigger

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Bacterium Clostridium perfringens may be MS trigger

Postby slghmevp » Fri Oct 18, 2013 1:29 am

We have isolated Clostridium perfringens type B, an epsilon toxin-secreting bacillus, from a young woman at clinical presentation of Multiple Sclerosis (MS) with actively enhancing lesions on brain MRI. This finding represents the first time that C. perfringens type B has been detected in a human. Epsilon toxin’s tropism for the blood-brain barrier (BBB) and binding to oligodendrocytes/myelin makes it a provocative candidate for nascent lesion formation in MS. We examined a well-characterized population of MS patients and healthy controls for carriage of C. perfringens toxinotypes in the gastrointestinal tract. The human commensal Clostridium perfringens type A was present in approximately 50% of healthy human controls compared to only 23% in MS patients. We examined sera and CSF obtained from two tissue banks and found that immunoreactivity to ETX is 10 times more prevalent in people with MS than in healthy controls, indicating prior exposure to ETX in the MS population. C. perfringens epsilon toxin fits mechanistically with nascent MS lesion formation since these lesions are characterized by BBB permeability and oligodendrocyte cell death in the absence of an adaptive immune infiltrate.


http://www.plosone.org/article/info%3Ad ... ne.0076359
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Re: Bacterium Clostridium perfringens may be MS trigger

Postby cervocuit » Fri Oct 18, 2013 1:55 am

Have they found the occult GI phatogen driving MS symptomes that Thomas Borody was talking about ?

From the abstract of MSRC
http://www.ms-uk.org/MSnews
...
"But one of my favorite approaches is development of a probiotic cocktail that delivers bacteria that compete with, and destroy, C. perfringens types B and D," Vartanian says. "It would be such a beautiful and natural way to treat the gastrointestinal system and solve the problem. We are also starting to work on this approach."

The ultimate probiotic cocktail already exist inside healthy persons and can be easily transplanted.
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Re: Bacterium Clostridium perfringens may be MS trigger

Postby Leonard » Fri Oct 18, 2013 3:09 am

here is another article http://weill.cornell.edu/news/releases/ ... 6_13.shtml

fascinating...

noted the 33 kD protoxin; perhaps this is the mysterious 36,000 Dalton toxic protein in Gay's paper...
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