Focus on the gut-brain axis

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Focus on the gut-brain axis

Postby Petr75 » Sun Nov 04, 2018 12:14 pm

2018 Oct 7
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Canada
Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome.
https://www.ncbi.nlm.nih.gov/pubmed/30310254

Abstract
The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results.

Free PMC Article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175760/
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Re: Focus on the gut-brain axis

Postby NHE » Sun Nov 04, 2018 3:36 pm

This paper states...

One of the first components of the intestinal barrier is a thick mucus layer forming a protective film, enriched by secretory IgA and antimicrobial peptides and proteins. Oral supplementation with lecithin and phosphatidylcholine can adhere to the intestinal mucosa, strengthening the mucus layer and improving barrier function[44-46].

Another paper states that 2 g/day of phosphatidylcholine was helpful for restoring the gut's mucosal layer and relieving symptoms of chronic steroid-refractory ulcerative colitis. Sunflower lecithin containing phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine is available fairly inexpensively. Has anybody tried this?
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Re: Focus on the gut-brain axis

Postby Leonard » Tue Nov 06, 2018 3:18 am

A bad gut leads to a deficient methylation/failure of epigenetic regulation and cellular expression.
This in turn leads to elevated peroxynitrite and mounting oxidative stress at cellular level.
See also steps 5 and 6 of: general-discussion-f1/topic15188-825.html#p251748
It is yet another pubication that fits the overall concept.
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Re: Focus on the gut-brain axis

Postby frodo » Wed Nov 07, 2018 6:37 am

Thanks. A lot of papers are comming out now speaking about the gut connection. Let's hope that they are now on the right track.

By the way, the paper is freely available here:

https://www.wjgnet.com/1007-9327/full/v24/i37/4217.htm
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Re: Focus on the gut-brain axis

Postby Petr75 » Wed Nov 07, 2018 7:49 am

The primary problem is gut, I also hope.
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