Squeakycat wrote:Here is one study of zinc in EAE. It does conclude that there was a reduction in severity, but compare that to a complete remission which was sustained for the duration of the study in 100% of the mice treated with calcitriol +D3:
The zinc/MS question seems convoluted at best (at least in my mind at this time).
Here's an EAE study that found improvements with zinc & copper chelation...
Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model.
Neurobiol Dis. 2013 Jun;54:382-91. doi: 10.1016/j.nbd.2013.01.012. Epub 2013 Jan 27.
- The present study aimed to evaluate the therapeutic potential of clioquinol (CQ), a metal chelator, on multiple sclerosis pathogenesis. Experimental autoimmune encephalomyelitis was induced by immunization with myelin oligodendrocyte glycoprotein (MOG(35-55)) in female mice. Three weeks after the initial immunization, demyelination and immune cell infiltration in the spinal cord were analyzed. CQ (30mg/kg) was given by gavage once per day for the entire experimental course. CQ profoundly reduced the daily clinical score and incidence rate of EAE mice. The CQ-mediated inhibition of the clinical course of EAE was accompanied by suppression of demyelination and reduced infiltration by encephalitogenic immune cells including CD4, CD8, CD20 and F4/80 positive cells. CQ also remarkably inhibited EAE-associated BBB disruption and MMP-9 activation. Autophagy contributes to clearance of aggregated proteins in astrocytes and neurons. The present study found that EAE increased the induction of autophagy and CQ further increased this expression. Furthermore, the present study found that post-treatment with CQ also reduced the clinical score of EAE and spinal cord demyelination. These results demonstrate that CQ inhibits the clinical features and neuropathological changes associated with EAE. The present study suggests that transition metals may be involved in several steps of multiple sclerosis pathogenesis.
So, has there been a clinical trial of zinc in actual MS patients? I would like to see that paper even if it was just a small phase Ia.