Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis (1998)http://www.sciencedirect.com/science/ar ... 409800370X
"The serum levels of vitamin E and the serum vitamin E/cholesterol ratio were significantly lower in MS patients when compared with controls (P<0.05 and P<0.01, respectively). These values were not correlated with age, age at onset and duration of the disease in the patients group."
Nonenzymatic antioxidants of blood in multiple sclerosis (1999) http://www.springerlink.com/content/dflv5gx818uhy8dd/
We investigated the plasma level of lipid peroxides ... (glutathione, α-tocopherol
, retinol, plasma sulfhydryl groups, and uric acid) in multiple sclerosis patients with exacerbation or in remission, including a group treated with β-interferon. ... the ratio of plasma α-tocopherol to cholesterol plus triglyceride was decreased (P < 0.001)
. ... β-Interferon increased plasma α-tocopherol levels (P < 0.001)
Measurement of Low-Molecular Weight Antioxidants, Uric Acid, Tyrosine and Tryptophan in Plaques and White Matter from Patients with Multiple Sclerosis (1992)http://content.karger.com/ProdukteDB/pr ... tNr=234298
The levels of the antioxidants
ascorbic acid, cysteine, reduced glutathione and a-tocopherol
, of the free-radical marker uric acid and of the amino acids tyrosine and tryptophan were measured by means of high-pressure liquid chromatography in plaques, adjacent white matter and distant white matter from patients with multiple sclerosis
, and in central nervous system tissue from patients without neurological diseases. ... α-tocopherol was lowest in plaques and highest in distant white matter in all cases
SELENIUM, VITAMIN E AND COPPER IN MULTIPLE SCLEROSIS (1976) (i know i have posted this study elsewhere ... wish i could see the full data regarding the values for vitamin e, since we all know my opinion of the value of 'international normal ranges' is so very high :S )http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract
There has been accumulation of the nutritional muscular dystrophy of the cattle in a certain western district of Finland where the prevalence of multiple sclerosis (MS) is also highest. This animal disease is due to lack of selenium (Se) and vitamin E. The Se content of whole blood was low (52.8 ± 11.3 ng/ml) in MS patients from this high-risk area compared to the controls (68.8 ± 11.0). The data for serum failed to confirm this tendency. All Se values appeared to he lower than international values suggested. The values for hoth vitamin E and copper were within the international normal range.
Vitamin E in Humans: Demand and Delivery (1996)http://www.annualreviews.org/doi/abs/10 ... 196.001541
"How much vitamin E is enough? An established use of supplemental vitamin E in humans is in the prevention and therapy of deficiency symptoms. ... In healthy individuals, a daily intake of about 15-30 mg of α-tocopherol is recommended to obtain “optimal plasma alpha-tocopherol concentrations” (30 μM or greater)."