"Multiple sclerosis and vitamin B12 metabolism"
… It is remarkable that, despite the fact that the age range is so different, the sex, racial and geographical distribution of MS and PA [pernicious anemia – the extreme form of B12 deficiency] are similar. Thus PA is a higher prevalence in northern Europe compared with Southern Europe in tropical areas, a diminishing prevalence from the north to the south of the UK and a higher incidence in white than black North Americans. The female-to-male ratio in both disorders is 1-3:1. Najim Al-Din et al have also drawn attention to some similarities in the HLA associations of MS and PA.…
There are many footnotes to support these statements.
Must watch: "Everything You Want Your Doctor to Know about Vitamin B12"
I highly recommend this 50-minute documentary from the filmmaker Elissa Leonard, featuring Sally M. Pacholok, RN, BSN & her husband Jeffrey J. Stuart, D.O. (authors of the book, Could It Be B12? An Epidemic of Misdiagnoses); Lawrence Solomon, M.D., hematologist with Yale Medical School; Ralph Green, M.D., hematologist at UC Davis; and Donald Jacobsen, PhD, at the Cleveland Clinic (Homocysteine Research Lab).
@1:23 "The neurological manifestations well precede the hematological manifestations."
@1:46 "In 1948 scientists isolated a red crystalline pigment and named it vitamin B12. It is a primordial molecule responsible for the health of all the DNA in all our cells. The Framingham Offspring Study suggests 40% of Americans have suboptimal B12."
Cardinal Signs of Anemia Due to Vitamin B12 Deficiency:
Shortness of breath
Swollen tongue that may appear dark red
Numbness or tingling in your hands and legs
Mental confusion or forgetfulness
Signs and Symptoms of B12 Deficiency:
#1 Peripheral Neuropathy
Sore Mouth or Tongue
Stomach and G.I. Problems
Limb Movement Disorders
Thoughts of Suicide
Risk factors for B12 deficiency:
Age over 50
Low Stomach Acid
Eating Disorders Parasites
Use of Acid-Blockers
Use of Oral Birth Control Pills
Use of Metformin
Nitrous Oxide Anesthesia
Intestinal Bacterial Overgrowth
Here is more background information on the documentary: http://b12awareness.org/2013/01/21/2013 ... completed/