Magnesium is lower in MS patients

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Magnesium is lower in MS patients

Postby NHE » Thu Oct 19, 2017 4:39 am

Magnesium was found to be significantly lower in MS patients vs. controls.

Comparison of serum Concentration of Se, Pb, Mg, Cu, Zn, between MS patients and healthy controls.
Electron Physician. 2016 Aug 25;8(8):2759-2764.

    INTRODUCTION: Multiple Sclerosis (MS) is defined as one of the inflammatory autoimmune disorders and is common. Its exact etiology is unclear. There are some evidences on the role of environmental factors in susceptible genetics. The aim of this study is to evaluate the possible role of Selenium, Zinc, Copper, Lead and Magnesium metals in Multiple Sclerosis patients.

    METHODS: In the present analytical cross-sectional study, 56 individuals including 26 patients and 30 healthy controls were enrolled in the evaluation. The serum level of Se, Zn, Cu, Pb were quantified in graphite furnace conditions and flame conditions by utilizing an atomic absorption Perkin Elmer spectrophotometer 3030. The serum levels of Mg were measured by auto analyzer 1500 BT. The mean level of minerals (Zn, Pb, Cu, Mg, Se) in serum samples were compared in both cases and controls. The mean level of minerals (Zn, Pb, Cu, Mg, Se) in serum samples were compared in both cases and controls by using independent-samples t-test for normal distribution and Mann-Whitney U test as a non-parametric test. All statistical analyses were carried out using SPSS 11.0.

    RESULTS: As well as the Zn, Cu, and Se, there was no significant difference between MS patients and healthy individuals in Pb concentrations (p-value = 0.11, 0.14, 0.32, 0.20 respectively) but the level of Mg was significantly different (p= 0.001).

    CONCLUSION: All serum concentrations of Zn, Pb, Se, Cu in both groups were in normal ranges and there was no difference in MS patients compared with the healthy group who were matched in genetics. Blood level of Mg was significantly lower in MS patients. But it should be noted that even with the low level of serum magnesium in MS patients, this value is still in the normal range.

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Re: Magnesium is lower in MS patients

Postby jimmylegs » Thu Oct 19, 2017 5:09 am

had touched on this one last year in the magnesium topic
natural-approach-f27/topic18568-150.html#p245051

still annoying not to be able to see serum mag means, sd or max/min for the groups evaluated.

given that levels in patients were lower than controls but still normal, i'd appreciate seeing the numbers. from what's published, it appears that they'd help reinforce what we keep saying about *where*, within that normal range, you want your serum levels to be for consistency with levels observed in healthy controls. we need replication on the targets we should be going for within the normal range. not just 'significantly lower normal'.
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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Re: Magnesium is lower in MS patients

Postby NHE » Thu Oct 19, 2017 10:47 am

jimmylegs wrote:still annoying not to be able to see serum mag means, sd or max/min for the groups evaluated.

Yes, it's a bit pathetic for a published paper, no graphs, data tables, etc. Unbelievable.
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Re: Magnesium is lower in MS patients

Postby jimmylegs » Thu Oct 19, 2017 12:47 pm

yea i can't even find an 'Electronic Physician' journal listed at all via SJR or Scopus. interim rating:

1 TiMS stink-eye.

@*
~

related: https://www.insidehighered.com/views/20 ... ated-essay
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 10780
Joined: Sat Mar 11, 2006 3:00 pm


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