Search found 1438 matches

by Scott1
10 hours ago
Forum: General Discussion
Topic: Swimming training
Replies: 2
Views: 20

Re: Swimming training

Hi, The two things to note in this piece, achieved here by giving mice a sink or swim option, is exercise a) boosts brain derived neurotrophic factor (BDNF) and b) increases IL10. There is actually quite a lot of studies that show exercise increases BDNF. In turn, higher BDNF boosts the anti-inflamm...
by Scott1
22 hours ago
Forum: General Discussion
Topic: Neck/Back Pain
Replies: 2
Views: 31

Re: Neck/Back Pain

Hi, You can get a lot of pains like that. They can pop up anywhere. The best way I have found to deal with it is to regularly have tight muscles massaged and do a lot of eccentric muscle movement. That is the type of movement you get from Pilates exercises. I would be in trouble if I didn't get mass...
by Scott1
3 days ago
Forum: Undiagnosed
Topic: Any thoughts would be greatly appreciated
Replies: 8
Views: 98

Re: Any thoughts would be greatly appreciated

Hi, Firstly, we're not doctors so it's just an observation. You should ask them why the white blood cell results have an "H" next them and why there's an "H" next to urine bacteria. If there is an infection, white blood cell numbers will be up so I'd look in that direction first. The good news is mo...
by Scott1
4 days ago
Forum: General Discussion
Topic: 2019 Review: MS in 2018: new therapies and biomarkers
Replies: 13
Views: 369

Re: 2019 Review: MS in 2018: new therapies and biomarkers

Hi, We might go around in circles here. To my mind this was the most interesting article (published in "Cell") last year. https://www.cell.com/action/showPdf?pii=S0092-8674(18)31027-4 The researchers linked the influence of memory B cells with autoreactive CD4T cells in the HLA-DR15 Haplotype (which...
by Scott1
4 days ago
Forum: Introductions
Topic: new here and not sure what to expect
Replies: 4
Views: 82

Re: new here and not sure what to expect

Hi, We are all not in a position to see what you can see. At 68, she is not elderly but often, particularly older people, who have a prolonged stay in hospital with an illness end up with an underlying infection. Urinary tract infections are very common. They can be very debilitating and present wit...
by Scott1
2 weeks ago
Forum: Undiagnosed
Topic: Connecting the dots - 43 years of symptoms
Replies: 9
Views: 807

Re: Connecting the dots - 43 years of symptoms

Hi, For both of you, what is your blood pressure. For Sweetsue, I think you need to breakdown what's happening and not put it under one umbrella. Your sleeping issue, chest and cough problems all sound related. I'd ask to see an ENT specialist about those. The falling asleep when sitting suggests yo...
by Scott1
2 weeks ago
Forum: General Discussion
Topic: Optic neuritis?
Replies: 4
Views: 286

Re: Optic neuritis?

Hi, Unfortunately your question might generate an answer that fits but that doesn't necessarily mean it's the right one. I'd trust your doctor. He is trained and we aren't. His treatment is likely to be a corticosteroid. If trochleitis is a correct diagnosis, then treatment will likely work. If it i...
by Scott1
3 weeks ago
Forum: General Discussion
Topic: My Story - Still waiting
Replies: 9
Views: 595

Re: My Story - Still waiting

Hi, If you have lesions on your optic nerve but the brain and spine are clear, it puts you at risk of being dismissed. That's not what should happen. Ask if you can be checked for Neuromyelitis optica. There is a serum antibody called NMO-IgG that is present in the majority of people with this. It's...
by Scott1
4 weeks ago
Forum: General Discussion
Topic: Cholesterol level correlate with disability score
Replies: 3
Views: 903

Re: Cholesterol level correlate with disability score

Hi, I think we have to be careful here to not mix apples with pears. The second study is really focusing on VLDL-2. There are distinctions between the manufacture of VLDL-1 and 2. Obesity is a major focus of research when you get down to that level and there are distinct differences between males an...
by Scott1
1 month ago
Forum: General Discussion
Topic: Cold creeping up my arms and legs
Replies: 9
Views: 1037

Re: Cold creeping up my arms and legs

Hi, I'm not sure I know what under eating really means. Some people swear by fasting. Have you been checked for Diabetes Insipidus? It's not the normal diabetes so don't jump the gun. Have a look at this- https://www.betterhealth.vic.gov.au/health/ConditionsAndTreatments/diabetes-insipidus Regards,
by Scott1
1 month ago
Forum: General Discussion
Topic: Does my husband REALLY have MS?
Replies: 8
Views: 904

Re: Does my husband REALLY have MS?

Hi, Let's deal with the foot first. Although he cramps in the foot there can be a lot of other parts of the leg involved. To walk, you want your foot to land on the heel, roll through the foot and spring off the toes. Whilst this happens you want your leg to be in line and supple. If not, there's a ...
by Scott1
1 month ago
Forum: General Discussion
Topic: Does my husband REALLY have MS?
Replies: 8
Views: 904

Re: Does my husband REALLY have MS?

Hi, If you are both still able to run then you are way ahead of me. No one has ever described me as having a particular form of MS. I've obviously oscillated between being very bad and pretty good. As I constantly intervene by using exercise, massage and dry needling for my muscles plus supplements,...
by Scott1
1 month ago
Forum: Undiagnosed
Topic: Constellation of symptoms
Replies: 32
Views: 1397

Re: Constellation of symptoms

Hi, On that last issue, maybe get the ENT man to look at your tonsils as well as why your nose is blocked. It does make a big difference. Unfortunately, we are talking about surgery and I expect you will damn me to hell if you have to go through with it. Only an ENT surgeon can make the call. GPs ge...
by Scott1
1 month ago
Forum: General Discussion
Topic: Does my husband REALLY have MS?
Replies: 8
Views: 904

Re: Does my husband REALLY have MS?

Hi, I feel for both of you having to deal with this. I'd say, yes, you both have MS. When I was diagnosed in the early 1990s, the definitions were not as refined as today. I was just diagnosed as clinically definite MS. This classification between RRMS and PPMS isn't really that old. It is an evolvi...
by Scott1
1 month ago
Forum: General Discussion
Topic: Walk Downhill
Replies: 4
Views: 842

Re: Walk Downhill

Hi Elliot, That is a good observation. There is a long list of studies that demonstrate that, beyond the initial phase, there is almost no correlation between EDSS scores and lesions. That's why an MRI can't predict disease progression. The study did divide MS into two phases : "early inflammatory d...