Search found 1008 matches

by Leonard
Sat Feb 01, 2020 6:24 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Re: A new concept for MS and other autoimmune diseases

Reflections on cellular fitness On the protective effect of childhood sun exposure [/size] A childhood in the sun may cut the risk of getting an autoimmune disease later in life, including the risk of getting MS. Central in the new theory on health and disease is the cellular fitness. A vibrant and...
by Leonard
Sat Dec 21, 2019 10:38 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Re: A new concept for MS and other autoimmune diseases

A perspective on the link between mitochondrial functioning and disease Most of our body’s nucleated cells contain 500 to 2000 mitochondria, some sources say 1500 to 3000, the heart muscle up to 5000. In the cone cell photoreceptors of the eye, mitochondria make up 80% of the intracellular volume. I...
by Leonard
Tue Nov 05, 2019 7:13 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Re: A new concept for MS and other autoimmune diseases

Our understanding of the cellular biology is focussed on the energy metabolism; the evolutionary path of our cells is described under undisturbed physiological conditions. But in reality, cellular development took place under very unfriendly and harsh conditions, with agression of bacteria, viruses ...
by Leonard
Wed Oct 30, 2019 7:01 am
Forum: General Discussion
Topic: NOX inhibitors
Replies: 1
Views: 200

Re: NOX inhibitors

yes, oxidative stress is a key player in many chronic (autoimmune) diseases. and of course, inhibition of NOX can improve disease conditions. I think the superoxide is produced by EBV B cells, to kill the pathogen. For that the superoxide forms peroxynitrite locally, to obstruct the feeding of the v...
by Leonard
Wed Oct 30, 2019 6:53 am
Forum: General Discussion
Topic: Focus on the gut-brain axis
Replies: 62
Views: 5933

Re: Focus on the gut-brain axis

I think they still miss essential elements, that is the virus and SNPs. But yes, the gut biota influence the immune system/immunity, both inside the brain (microglia as the first line of defense against viral infection) and outside the brain. And with that the anti-viral properties. https://elifesci...
by Leonard
Fri Oct 25, 2019 6:06 am
Forum: General Discussion
Topic: Focus on the gut-brain axis
Replies: 62
Views: 5933

Re: Focus on the gut-brain axis

2019 Jul 19 Department of Surgical Sciences, University of Turin, Turin, Italy Inflammation in gastrointestinal disorders: prevalent socioeconomic factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650093/ Abstract Western populations harbor a chronic inflammation pattern that lacks organ cardin...
by Leonard
Fri Oct 18, 2019 2:17 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Re: A new concept for MS and other autoimmune diseases

Copied from the other thread on genetic and environmental risk factors on https://www.thisisms.com/forum/viewtopic.php?f=1&t=31202 In my case, the left Internal Jugular Vein (IJV) is dominant. Which is a kind of strange. Normally left and right IJVs should be equal. So why is that? That is because t...
by Leonard
Fri Oct 18, 2019 1:45 am
Forum: General Discussion
Topic: Environmental and genetic risk factors
Replies: 5
Views: 414

Re: Environmental and genetic risk factors

.. cards were dealt before birth, still later it was just a bad game.. Correct. In my case, the left Internal Jugular Vein (IJV) is dominant. Which is strange. Normally they should be equal. So why is that? Because the right IJV was blocked, a birth defect. During the foetal phase, the left IJV gre...
by Leonard
Sun Oct 13, 2019 10:36 pm
Forum: General Discussion
Topic: Environmental and genetic risk factors
Replies: 5
Views: 414

Re: Environmental and genetic risk factors

This nitty gritty stuff only adds to the confusion. We should begin at a higher abstraction level.
by Leonard
Sat Sep 28, 2019 12:27 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Re: A new concept for MS and other autoimmune diseases

From the other thread on Why Don't We Have a Vaccine Against Autoimmune Diseases? 2019 Roseman University College of Medicine, Las Vegas Why Don't We Have a Vaccine Against Autoimmune Diseases? - A Review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640150/ Abstract This review examines some of th...
by Leonard
Sat Sep 28, 2019 12:12 am
Forum: General Discussion
Topic: Why Don't We Have a Vaccine Against Autoimmune Diseases?
Replies: 1
Views: 271

Re: Why Don't We Have a Vaccine Against Autoimmune Diseases?

https://pdfs.semanticscholar.org/0e4f/fc1ed59fb399399547b68488b9f90be44f6f.pdf Vaccination and Autoimmunity—‘Vaccinosis’: A Dangerous Liaison? quote The question of a connection between vaccination and autoimmune illness (or phenomena) is surrounded by controversy. A heated debate is going on regard...
by Leonard
Mon Sep 23, 2019 1:03 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Re: A new concept for MS and other autoimmune diseases

Besides the medical technical aspects, we have encountered here many times the systemic aspects of the problem. As regards the latter, we may feel encouraged by this article where we learn that ever more prominent doctors speak out against the medical establishment and that it is starting to look li...
by Leonard
Mon Sep 23, 2019 12:10 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Re: A new concept for MS and other autoimmune diseases

2019 Jul 16 Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634972/ Abstract S...
by Leonard
Mon Sep 23, 2019 12:06 am
Forum: General Discussion
Topic: Focus on the gut-brain axis
Replies: 62
Views: 5933

Re: Focus on the gut-brain axis

2019 Jul 16 Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634972/ Abstract S...
by Leonard
Sun Sep 01, 2019 11:20 pm
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 901
Views: 210284

Autoimmunity and our society

The mystery of autoimmune diseases revealed Taking control of autoimmunity: a scourge of our modern age Autoimmune diseases—such as multiple sclerosis (MS), lupus, Crohn’s disease, type 1 diabetes, and rheumatoid arthritis—cause the body to destroy itself. Recent studies suggest that the mechanisms...