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Theoretical Immunology and Chronic Disease A New Horizon for Thinking [/size] Biological life on earth has evolved over several billion years on the basis of relatively stable DNA double helix structures. The development of the directly autocatalytic mechanisms fundamental to living systems began w...

In the years prior to my MS diagnosis and the major flare up, I had an agitated skin in the neck when shaving. I remember that a doctor from my employer where I was for an annual check up suggested to start using an after shave. [Post script: Now that my memory comes back, I also had a stiff neck an...

Critics might argue that herpes is a double stranded DNA virus and that it may not unravel that easily in the cellular machinery. And therefore that interaction with the HERV resulting in a repackaging of RNA material is not obvious. But it has been known for some time that herpes viruses integrate ...

I think that after my 10,000 hours I am getting into the flow of things. I am sure this is not an immediate solution for us or for MS but to know what it is is the first step towards prevention and effective therapies. Based on the last few pages of this thread, the new grand theory might now look a...

I was looking through the pile of papers that I collected in recent years and found interesting material on the HERV. It is the missing piece that puts it all together. I then drafted the following text: Autoimmunity: viral recombination on the edge of the self [/size] Over many millions, perhaps ev...

Australian researchers claim two existing drugs could 'cure' COVID-19
https://www.dailymail.co.uk/news/articl ... virus.html

A new grand theory on health and disease ... might now look a bit as follows: 1. It all starts with a viral homeostasis Redox biology is fully intertwined, multiple signaling mechanisms, pathogenic & beneficial effects of oxidative stress, autoimmunity 2. Cellular fitness: a decisive factor between...

Protecting us against our smallest but yet our biggest enemies: What the state can’t do even today, church has done for the last 2000 years [/size] Autoimmunity: it all starts with a viral homeostasis Evolution favors hosts that develop strategies to avoid or limit pathogen infections, and pathogen...

Hallo lyndacarol, On your question, I have added the link to the essay in the above posting. I seem to remember you from the past when we had an exchange of ideas on this very forum on the role of insulin and cellular feeding in MS. This was in the Autumn of 2010. I had read somewhere that there is ...

Reflections on cellular fitness On the protective effect of childhood sun exposure [/size] A childhood in the sun may cut the risk of getting an autoimmune disease later in life, including the risk of getting MS. Central in the new theory on health and disease is the cellular fitness. A vibrant and...

A perspective on the link between mitochondrial functioning and disease Most of our body’s nucleated cells contain 500 to 2000 mitochondria, some sources say 1500 to 3000, the heart muscle up to 5000. In the cone cell photoreceptors of the eye, mitochondria make up 80% of the intracellular volume. I...

Our understanding of the cellular biology is focussed on the energy metabolism; the evolutionary path of our cells is described under undisturbed physiological conditions. But in reality, cellular development took place under very unfriendly and harsh conditions, with agression of bacteria, viruses ...

yes, oxidative stress is a key player in many chronic (autoimmune) diseases. and of course, inhibition of NOX can improve disease conditions. I think the superoxide is produced by EBV B cells, to kill the pathogen. For that the superoxide forms peroxynitrite locally, to obstruct the feeding of the v...

I think they still miss essential elements, that is the virus and SNPs. But yes, the gut biota influence the immune system/immunity, both inside the brain (microglia as the first line of defense against viral infection) and outside the brain. And with that the anti-viral properties. https://elifesci...

2019 Jul 19 Department of Surgical Sciences, University of Turin, Turin, Italy Inflammation in gastrointestinal disorders: prevalent socioeconomic factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650093/ Abstract Western populations harbor a chronic inflammation pattern that lacks organ cardin...