The previous posting stressed the importance of a good health of the small vessels.
After many years of CCSVI, a lot of damage will have been caused to the small vessel walls in parts of the brain and spinal column. There can be no doubts anymore about the relationship. This recent publication by the US Society of Interventional Radiologists (SIRs) shows that 95 percent of the individuals evaluated had venous obstructions http://www.cisionwire.com/society-of-in ... s,c9232953
In the affected areas, endothelial functioning will be considerably weakened. Infection with a bacteria or virus may then further impair the endothelial functioning (by receptor blocking or dysfunctioning) to a point where inflammation and acute relapses occur. If severe enough, one will be diagnosed with RR MS.
In the second progressive stage, experience has shown that progression can be stopped through diet, even to a point where the disease may be somewhat reversed. This is most clearly demonstrated by the positive effects of the Swank low-fat diet (140 patients over 34 years) and other diets (Terry Walsch etc). The Mediterenean diet (see above posting) shows a large overlap with the Swank diet and will help to preserve endothelial health in those already weakened small vessels. Hence, in the second progressive stage, maintaining vessel wall functioning is critical while further aggravated endothelial conditions would lead to further disease progression.
We may now ask what mechanism is underlying demyelination and axonopathy in this second progressive stage. One mechanism that I can see is a further receptor dysfunctioning that aggravates micro-cellular feeding conditions and natural transcription processes (for generating oligodendrocytes that then compete). This mechanism will then further weaken the already vulnerable myeline and axons.
A possible second mechanism involves the immune system. I can see that the weakened myeline and axons will cause a low grade inflammation; I am sure that the metabolism counts many (neuro-)signalling pathways and some of them will get excited to signal that there are things going wrong.
[As a side step in the reasoning, I am convinced that vitamin C, vitamin D and cortisol do not work inflammation suppressive but rather improve the micro-cellular nutritional conditions such that (neuro-)signalling pathways calm down. It looks then as if things work suppressive but the real underlying mechanism at work here works the other way around, in fact not to suppress but to enhance… dogma1].
Now going back to the main line of reasoning: The fact that MS patients who strictly adhere to a Swank low-fat diet stabilise provides a clear indication that through diet you can change the course of the disease. Possibly, this happens by keeping key receptors healthy by improving conditions and the endothelial functioning in the smallest vessels.
I am convinced that sugar and/or for instance wheat flour are a factor here. Anything that pushes the blood sugar high up is bad; high insulin peaks are bad as they reduce insulin sensitivity. See e.g. http://www.wheatbellyblog.com/about-the-author/
And possibly the super-sticky MGmin LDL cholesterol (that grows on sugar and saturated fats) is further sealing vessel walls. Here the common diabetes medication Metformin may help break down this ultrabad cholesterol, and arguably also help keep insulin peaks down...
But the diet also works on the gut. See http://www.vitamindandms.org/
and http://web.inter.nl.net/users/vitaminda ... -in-ms.pdf
An unbalanced gut flora arguably manipulates T/B cells that then migrate through the liver to the brain. These bad T/B cells would then cause further damage to the already vulnerable and low-level inflammated myeline. These bad T/B are also understood to be the cause of many 'chronic immune' system diseases' as diabetes, asthma and rheumatic disorders.
This latter is what the neurologists have always believed is causing the MS. This latter is also what is common believe in the medical world for what causes many chronic diseases. But if one looks at the total picture from the outside, one really starts to wonder whether that concept is correct
... And whether one should really speak here of an 'immune system disease' or, alternatively, whether what one sees is really the consequence of other things such as impaired micro-cellular feeding and receptor dysfunctioning as the following cases would seem to hint at.
The above articles on Mediterenean diet and on the wheat flour, returning people from pre-diabetic to non-prediabetic with marked improvements or total relief from arthritis or improvement in asthma, a relief of acid reflux and irritable bowel syndrome, disappeance of numbness etc would suggest that perhaps here lies the origin/etiology of many chronic diseases while the excited immune system is in fact nothing else than a perfectly normal re
All blood from the gut passes through the liver. Hence, the liver may serve as an important gateway to stop bad things from the gut from proliferating through the body. For us, the case of the Caucasian women with MS is an interesting case. When this women got a new liver, she saw her MS reverse. I believe that her new liver changed the type of cholesterol being produced and that it is precisely that what caused her MS improvement. I can not imagine her new liver being a better gate for bad T/B cells. THIS WOULD SUGGEST THAT THE DOGMATIC BELIEVE WIDELY HELD IN THE MEDICAL WORLD OF A CHRONIC IMMUNE SYSTEM DISEASE IS BASED ON WRONG PRESUMPTIONS. And for us, it would suggest that the fact that we have not yet found a solution for arresting MS progression is caused by a completely wrong understanding of underlying disease mechanisms.