ok so this is more general, but it goes to how people might end up predisposed to ms from birth
maternal zinc deficiency and birth defectsregimens-f22/topic2489-405.html#p195460
"Almost all of the full-term fetuses produced under such conditions showed gross congenital malformations encompassing a wide variety of organ systems, including skeletal, brain, eye, heart, lung, and urogenital defects"
"Special attention was given to malformations of the central nervous system and to tissue anomalies not recognizable by gross inspection of the fetuses"
"In the course of prenatal zinc deficiency experiments, congenital hydrocephalus was frequently encountered ... various types of aqueduct stenosis or obliteration"
"Maternal zinc status: a determination of central nervous system malformation"
"Risk of diseases of metabolism such as atherosclerosis and adult onset diabetes mellitus is increased by fetal malnutrition. Deficiencies of micronutrients essential for methylation are believed to contribute to the phenomenon in part through epigenetic abnormalities. Zinc is one of the nutrients essential for the epigenome. Because the worldwide prevalence of zinc deficiency is at least 20% (JL: by 'normal' standards), fetal zinc deficiency is common. We suggest fetal zinc deficiency contributes to the pathogenesis of metabolic diseases in adults. ... We suspect that zinc deficiency is a far greater human health problem than is generally recognized."
"is it just me, or does this look like each individual's seed zinc fund for project life. environment/diet determines whether the account is accruing interest or being depleted, and when a given individual drains the account, that's when their personal wheels start to come off all the zinc-dependent enzymes, with consequences for regulation of genetic expression. may i say, bam.
Zinc content and distribution in the newborn liverhttp://www.ncbi.nlm.nih.gov/pubmed/8856577
The mean zinc concentration in the newborn liver was 639 micrograms/g of dry tissue (dt). A striking interindividual variability in zinc liver stores was observed; the hepatic concentration of the metal ranged from 300 to 1,400 micrograms/g dt