Hi Scott1~ I thought it was interesting that you mentioned taking vitamin C. Here is some info from the National Institutes of Health.
"Early research suggests that vitamin C supplements can destroy dietary vitamin B12. It isn't known whether this interaction is important, but to stay on the safe side, take vitamin C supplements at least 2 hours after meals."
Thank you for the link. Let me study it before I reply. I believe excess peroxynitrite is a result of the lack of B12. Here is some good information on how the nitric oxide cycle fails due to a lack of B12. This results in an over-production of peroxynitrite. If you scroll down, there are some good graphs.http://www.drmyattswellnessclub.com/B12MECFSarticle.htm
Here is some information from my book.
"Vitamin B12 neutralizes excess nitric oxide and prevents it from combining with O2- and forming peroxynitrite. The following studies are evidence that, due to a lack of B12, nitric oxide is playing a detrimental role in autoimmune disease.
1. Nagy, G., A. Koncz, T. Telarico, D. Fernandez, B. Ersek, E. Buzás, A. Perl. 2010. Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther 12(3):210.
2. Giovannoni, G., N.C. Silver, J. O’Riordan, R.F. Miller, S.J. Heales, J.M. Land, M. Elliot, M. Feldmann, D.H. Miller, E.J. Thompson. 1999. Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease. Mult Scler 5(5):335-41.
3. Wanchu, A., M. Khullar, A. Sud, P. Bambery. 2000. Elevated nitric oxide production in patients with Sjögren’s syndrome. Clin Rheumatol 19(5):360-4.
4. Pall, M.L. 2002. Levels of the nitric oxide synthase product citrulline are elevated in sera of chronic fatigue syndrome patients. J Chro Fatigue Synd 10(3/4):37-41.
As you would expect, all of the diseases which we have shown to lack B12, also have elevated nitric oxide. So yes, excess peroxynitrite will cause futher damage, but we are still left with going back far enough in the chain of events until we have found the source of all of these symptoms and findings. If lack of B12 leads to an excess of peroxynitrite, then we would need to address the cause of the lack of B12.