My husband and I have decided to start trying for a family
I was dx in Aug 2012 and on betaferon injections since
Two separate Neuros have advised its safe to stay on betaferon whilst conceiving and whilst pregnant.
Has anyone had any experience with this or know of someone who has? Ive read a few case studies where 300 odd women were tested and no signs of abnormal results that wouldnt occur in women without ms?
any help would be great
Interferon beta-1b is also known as: Betaseron, Extavia
Interferon beta-1b Pregnancy Warnings
A recently published consensus conference states that interferon beta-1b is contraindicated in pregnant or nursing women or those who are actively attempting to become pregnant. Therapy should be stopped in patients who become pregnant while taking interferon beta-1b. It may be most prudent to start (or restart) therapy as soon as possible after delivery or weaning to help decrease the increased risk of exacerbations during the postpartum period. Findings of right incomplete double renal pelvis and ureter in a 1-year-old child is believed to be associated to the interferon therapy used by the mother up to 2.5 months before her pregnancy. A Betaseron (R) Pregnancy Registry has been established to monitor maternal-fetal outcomes of pregnant women exposed to interferon beta-1b. Physicians are encouraged to obtain information at www.BetaseronPregnancyRegistry.com and register patients by calling 1-800-478-7049 (USA).
Interferon beta-1b has been assigned to pregnancy category C by the FDA. Animal studies of interferon beta-1b have failed to reveal a teratogenic effect, but abortifacient activity has been demonstrated at higher than recommended doses. Spontaneous abortion was reported in 4 women during a trial for the treatment of multiple sclerosis. There are no controlled data in human pregnancy. Interferon beta-1b is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk. The manufacturer recommends discontinuing therapy if the patient becomes or plans to become pregnant while taking interferon beta-1b.
Interferon beta-1b Breastfeeding Warnings
There are no data on the excretion of interferon beta-1b into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Pregnancy – Teratogenic Effects
Pregnancy Category C: Betaseron was not teratogenic at doses up to 0.42 mg/kg/day
when given to pregnant female rhesus monkeys on gestation days 20 to 70.
However, a dose related abortifacient activity was observed in these monkeys when
Interferon beta-1b was administered at doses ranging from 0.028 mg/kg/day to
0.42 mg/kg/day (2.8 to 40 times the recommended human dose based on body
surface area comparison). The validity of extrapolating doses used in animal
studies to human doses is not known. Lower doses were not studied in monkeys.
Spontaneous abortions while on treatment were reported in patients (n=4) who
participated in the Betaseron RRMS clinical trial. Betaseron given to rhesus monkeys
on gestation days 20 to 70 did not cause teratogenic effects; however, it is not known
if teratogenic effects exist in humans. There are no adequate and well-controlled
studies in pregnant women.
If the patient becomes pregnant or plans to become
pregnant while taking Betaseron, the patient should be apprised of the potential
hazard to the fetus and it should be recommended that the patient discontinue therapy.
A pregnancy registry has been established to monitor pregnancy outcomes of
women exposed to Betaseron while pregnant. Providers are encouraged to obtain
information on line at www.BetaseronPregnancyRegistry.com and register patients
by calling 1-800-478-7049.
It is not known whether Betaseron is excreted in human milk. Because many
drugs are excreted in human milk and because of the potential for serious adverse
reactions in nursing infants from Betaseron, a decision should be made to either
discontinue nursing or discontinue the drug, taking into account the importance
of drug to the mother.
andreagwolford wrote:I guess there's been a confusion here. Someone's up discussing about Betaferon while others have starting discussing about Betaseron. They both are meds and this is being quite confusing in here. Please make it clear before discussing
spokz wrote:After speaking to an obgyn they have mentioned previous history of other patients staying on betaferon!
I can stay on this treatment throughout pregnancy will no disadvantage to the child
Users browsing this forum: No registered users