Tysabri (Antegren or Natalizumab)

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Coronavirus (COVID-19): What You Need To Know

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What You Need To Know About Coronavirus (COVID-19)

What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...

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Last post

tysabri and LDN

Last post by Zac « Sun Mar 11, 2012 8:46 am
Replies: 1
by irishmum » Sun Mar 11, 2012 6:28 am

First post

Hi
Does anyone know or have experience of taking ldn while on tysabri? Is it contraindicated?

thanks and regards
M

Last post

Hi,
After discussing LDN with - Nurologist, GP and MS nurse they said the doses are so low it won't make a difference, the supplier was happy to...

1 Replies

1817 Views

Last post by Zac
Sun Mar 11, 2012 8:46 am
Immunological markers of optimal response to natalizumab

Last post by MSUK « Tue Feb 14, 2012 6:56 am

by MSUK » Tue Feb 14, 2012 6:56 am

Abstract

Objective To explore cell subsets and molecules that changed specifically in patients with multiple sclerosis (MS) who had an optimal...

0 Replies

2148 Views

Last post by MSUK
Tue Feb 14, 2012 6:56 am
Risk stratification for PML in patients treated with Tysabri

Last post by MSUK « Mon Feb 13, 2012 2:15 am

by MSUK » Mon Feb 13, 2012 2:15 am

Abstract

Natalizumab is a highly effective immunomodulator in the treatment of multiple sclerosis (MS).

Treatment with natalizumab has been...

0 Replies

2308 Views

Last post by MSUK
Mon Feb 13, 2012 2:15 am
rebound effect

Last post by wrkeller « Thu Feb 09, 2012 10:56 am
Replies: 2
by bonitamae » Fri Jan 20, 2012 4:56 pm

First post

I find myself at a crossroads------I stopped tysabri in august due to carrying the jcv virus. I was feeling better after change of diet--no...

Last post

I Have been looking at the subject since I recently entered a very active stage of my MS. I am JC virus positive and am planning to start the...

2 Replies

3104 Views

Last post by wrkeller
Thu Feb 09, 2012 10:56 am
Effectiveness of Tysabri in SPMS study

Last post by HarryZ « Fri Jan 27, 2012 6:30 am
Replies: 1
by MSUK » Thu Jan 26, 2012 6:54 am

First post

ASCEND study to evaluate the effectiveness of Tysabri in secondary progressive MS

Biogen Idec today announced a global Phase 3b study, ASCEND,...

Last post

The ASCEND study is part of the ongoing commitment of both Biogen Idec and Elan to find ways to improve the well-being of patients with multiple...

1 Replies

3022 Views

Last post by HarryZ
Fri Jan 27, 2012 6:30 am
FDA updates Tysabri® label & approves PML test

Last post by MSUK « Mon Jan 23, 2012 12:14 am

by MSUK » Mon Jan 23, 2012 12:14 am

Biogen Idec and Elan Corporation, plc announced that the U.S. Food and Drug Administration (FDA) has approved a product label change for Tysabri that...

0 Replies

2392 Views

Last post by MSUK
Mon Jan 23, 2012 12:14 am
Should I be concerned if..

Last post by LR1234 « Fri Jan 20, 2012 3:33 pm
Replies: 1
by Bender » Fri Jan 20, 2012 8:31 am

First post

Hey guys, I had my first Tysabri infusion last Wednesday with no steroid or weird reactions or anything. (it actually went quickly and smoothly, so I...

Last post

Sorry to hear of whats happened:( I hope you get over this blip soon.
I haven't had the guts to wear the eye patch in public when I had ON but I did...

1 Replies

2096 Views

Last post by LR1234
Fri Jan 20, 2012 3:33 pm
checking something my doc said

Last post by JJT « Thu Jan 05, 2012 1:56 pm
Replies: 4
by Bender » Wed Jan 04, 2012 4:47 pm

First post

Since my doctor took me off copaxone to switch over to tysabri, I've started having more balance issues and the sensation that I wasn't bearing my...

Last post

My wife has a steroid injection - Solu-medrol - (along with Benadryl) to avoid the severe reaction she had at infusion #18. She has just had infusion...

4 Replies

2587 Views

Last post by JJT
Thu Jan 05, 2012 1:56 pm
Tysabri Diary Updates - Neil and Eddie, New Diary - Richard

Last post by MSUK « Wed Dec 21, 2011 1:27 am

by MSUK » Wed Dec 21, 2011 1:27 am

Neil and Eddie have updated their MSRC Tysabri Diaries and we would like to welcome our newest diarist, Richard, to the panel.

You can read all the...

0 Replies

2075 Views

Last post by MSUK
Wed Dec 21, 2011 1:27 am
Tysabri Diary Update - Sue Lawrence

Last post by MSUK « Mon Dec 12, 2011 12:17 am

by MSUK » Mon Dec 12, 2011 12:17 am

Tysabri Diary Update - Sue Lawrence

Sue, one of our longest serving Tysabri diarists has sent in an inspiring and uplifting Tysabri Diary update....

0 Replies

1926 Views

Last post by MSUK
Mon Dec 12, 2011 12:17 am
Tysabri Diary Update

Last post by gymbuff « Tue Dec 06, 2011 1:27 am
Replies: 1
by MSUK » Mon Dec 05, 2011 3:38 am

First post

Tysabri Diary Update

Kara has kindly sent in an update to her Tysabri Diary,

You can read Kara's update at

Last post

Does anyone know why there is such a difference between infusions time in Germany and USA? Ireland has the same infusion regime as USA but the German...

1 Replies

1858 Views

Last post by gymbuff
Tue Dec 06, 2011 1:27 am
Tysabri an option for paediatric MS?

Last post by MSUK « Tue Nov 08, 2011 1:08 am

by MSUK » Tue Nov 08, 2011 1:08 am

A new study suggests that natalizumab (Tysabri, Biogen Idec/Elan) may be an effective option for the treatment of active paediatric multiple...

0 Replies

2034 Views

Last post by MSUK
Tue Nov 08, 2011 1:08 am
MSRC Tysabri Dairy Update

Last post by MSUK « Mon Nov 07, 2011 6:47 am

by MSUK » Mon Nov 07, 2011 6:47 am

Tysabri Diary Update

Fabiloa has kindly sent in her 11th Tysabri Infusion update.

You can read her latest diary update at

0 Replies

1946 Views

Last post by MSUK
Mon Nov 07, 2011 6:47 am
Tysabri Users Diaries on the MSRC Website

Last post by MSUK « Mon Nov 07, 2011 2:06 am

by MSUK » Mon Nov 07, 2011 2:06 am

Sonya has joined the MSRC Tysabri Users Diarists.

We would like to welcome Sonya to the MSRC Tysabri Users Diarists.

You can red Sonya's first...

0 Replies

2046 Views

Last post by MSUK
Mon Nov 07, 2011 2:06 am
Fast, accurate test for JC virus benefits patients with MS

Last post by Bender « Tue Nov 01, 2011 11:57 am
Replies: 1
by MSUK » Tue Nov 01, 2011 1:06 am

First post

A laboratory test developed by scientists at the National Institute of Neurological Disorders and Stroke (NINDS) is helping clinicians around the...

Last post

I didn't know this was news. My Doctor (in New York) ran the JC test on me when we started looking at Tysabri. I'm JC negative but we're not sure if...

1 Replies

2040 Views

Last post by Bender
Tue Nov 01, 2011 11:57 am
PML associated with natalizumab in paediatric MS

Last post by HarryZ « Mon Oct 31, 2011 6:08 am
Replies: 1
by MSUK » Mon Oct 31, 2011 12:03 am

First post

Background: In the pediatric Multiple Sclerosis (MS) population large and controlled studies on safety and efficacy of Natalizumab have not yet been...

Last post

Remember when MS was unheard of in children. That has now certainly changed with a Children's MS Clinic opened at St. Michael's Hospital in Toronto....

1 Replies

1586 Views

Last post by HarryZ
Mon Oct 31, 2011 6:08 am
33 deaths due to PML

Last post by HarryZ « Fri Oct 28, 2011 9:46 am
Replies: 5
by RuSmolikova » Sat Oct 15, 2011 11:16 am

First post

MS patients on Tysabri: 170 PML cases, 33 deaths already (as of 4-th of October 2011).
...as of the end of September 2011 approximately 63,500...

Last post

Biogen Idec announced today:
...as of the end of September 2011, we estimate that approximately 63,500 patients were on commercial and clinical...

5 Replies

2063 Views

Last post by HarryZ
Fri Oct 28, 2011 9:46 am
Neil's 3rd MSRC Tysabri Diary Update

Last post by MSUK « Wed Oct 26, 2011 7:01 am

by MSUK » Wed Oct 26, 2011 7:01 am

Neil's 3rd Tysabri Diary Update

Neil has tested positive for the JC virus, but is continuing his Tysabri treatments.

You can read his 3rd infusion...

0 Replies

1445 Views

Last post by MSUK
Wed Oct 26, 2011 7:01 am
Should I stay or should I go (off the medication)

Last post by hNickyOz « Tue Oct 25, 2011 7:43 am
Replies: 4
by flipflopper » Mon Sep 13, 2010 7:38 pm

First post

I will begin by apologizing for the long post.

I would like the wonderful people from this site to comment on my situation since it might make me...

Last post

I have only been on Ty for 2 months and am feeling worse. Should I stay on it

4 Replies

2961 Views

Last post by hNickyOz
Tue Oct 25, 2011 7:43 am
MS relapses seen after Tysabri drug holiday

Last post by MSUK « Mon Oct 24, 2011 2:36 am

by MSUK » Mon Oct 24, 2011 2:36 am

In patients with relapsing-remitting multiple sclerosis (MS), interrupting treatment with natalizumab (Tysabri, Biogen) often leads to relapse, a new...

0 Replies

1613 Views

Last post by MSUK
Mon Oct 24, 2011 2:36 am
Early use and long-term benefit of Tysabri

Last post by MSUK « Mon Oct 24, 2011 12:17 am
Replies: 2
by MSUK » Wed Oct 19, 2011 12:21 am

First post

Early use and long-term benefit of Tysabri (ECTRIMS and ACTRIMS)

Biogen Idec and Elan Corporation, plc today announced 28 company-supported...

Last post

Not to hand, sorry, will see if I can find them.

2 Replies

2831 Views

Last post by MSUK
Mon Oct 24, 2011 12:17 am
Case of PML after discontinuation of natalizumab

Last post by MSUK « Thu Oct 20, 2011 11:57 pm

by MSUK » Thu Oct 20, 2011 11:57 pm

Objective: To report on a case of progressive multifocal leukoencephalopathy (PML) after natalizumab (NTZ) treatment discontinuation.

Case report:...

0 Replies

1819 Views

Last post by MSUK
Thu Oct 20, 2011 11:57 pm
Tysabri PDUFA date extended by FDA

Last post by MSUK « Thu Oct 20, 2011 5:06 am

by MSUK » Thu Oct 20, 2011 5:06 am

Biogen Idec and Elan Corporation, plc announced that the U.S. Food and Drug Administration (FDA) has extended the initial PDUFA date for its review...

0 Replies

1725 Views

Last post by MSUK
Thu Oct 20, 2011 5:06 am
Multiple Sclerosis drug Tysabri 'reduces MS relapses'

Last post by HarryZ « Thu Oct 06, 2011 8:15 pm
Replies: 3
by MSUK » Wed Oct 05, 2011 1:24 am

First post

Patients with multiple sclerosis (MS) who took the new generation anti-inflammatory medication natalizumab for two years had a lower risk of...

Last post

If all of the current drugs are 30+-% effective, are they doing anything at all? Might just be the variability of MS. Seems to be too much of a...

3 Replies

1755 Views

Last post by HarryZ
Thu Oct 06, 2011 8:15 pm
Tysabri no longer covered by united healthcare

Last post by Bender « Sat Oct 01, 2011 10:29 pm
Replies: 1
by grahambo12 » Sat Oct 01, 2011 6:20 pm

First post

Has anyone heard anything about this? My dad was about to have his 6th infusion for tysabri when he called his infusion center to have them place the...

Last post

For what it's worth this sort of shit happens constantly, I had Blue Cross do the same with my Copaxone, and then reverse after we chased them down...

1 Replies

2052 Views

Last post by Bender
Sat Oct 01, 2011 10:29 pm
PML concern...

Last post by RuSmolikova « Thu Sep 22, 2011 9:40 pm
Replies: 2
by RuSmolikova » Tue Sep 06, 2011 9:44 am

First post

Is something in the air???

Last post

Videos for those interested in...

2 Replies

1663 Views

Last post by RuSmolikova
Thu Sep 22, 2011 9:40 pm
2 out of 3 patients report discontinuing Tysabri

Last post by MSUK « Thu Sep 22, 2011 7:42 am

by MSUK » Thu Sep 22, 2011 7:42 am

2 out of 3 patients report discontinuing Tysabri without doctors' advice

In the first report of a series on Multiple Sclerosis (MS) disease...

0 Replies

1554 Views

Last post by MSUK
Thu Sep 22, 2011 7:42 am
Christine's 4 Year Tysabri Update

Last post by MSUK « Tue Sep 20, 2011 5:31 am

by MSUK » Tue Sep 20, 2011 5:31 am

You can read her latest update to her MSRC Tysabri diary here -

0 Replies

1713 Views

Last post by MSUK
Tue Sep 20, 2011 5:31 am
Immunological and clinical consequences of Tysabri

Last post by NHE « Tue Sep 20, 2011 1:54 am
Replies: 1
by MSUK » Mon Sep 19, 2011 11:58 pm

First post

Immunological and clinical consequences of treating a patient with natalizumab

Abstract

Background: Long-term therapy with natalizumab...

Last post

Additional info from the abstract...
With no clinical, routine laboratory or cerebrospinal fluid (CSF) changes, MRI 2 months after PE demonstrated...

1 Replies

1381 Views

Last post by NHE
Tue Sep 20, 2011 1:54 am
Immune reconstitution inflammatory syndrome in natalizumab

Last post by MSUK « Mon Sep 19, 2011 12:59 am

by MSUK » Mon Sep 19, 2011 12:59 am

ABSTRACT

Objective: To study the outcome of patients with multiple sclerosis (MS) and with natalizumab-associated progressive multifocal...

0 Replies

1988 Views

Last post by MSUK
Mon Sep 19, 2011 12:59 am
12 more cases of brain infection, 5 more deaths in Tysabri

Last post by HarryZ « Fri Sep 02, 2011 5:51 am
Replies: 7
by MSUK » Fri Jul 15, 2011 10:54 am

First post

12 more cases of brain infection, 5 more deaths in Tysabri MS patients

Biogen Idec Inc. reported 12 more cases of a rare brain infection...

Last post

Just saw that the August figures show an increase of 12 more cases of PML bringing the total to 157. No info as to any increase in deaths.

Harry

7 Replies

2713 Views

Last post by HarryZ
Fri Sep 02, 2011 5:51 am
150 PML cases already...

Last post by HarryZ « Fri Aug 19, 2011 2:38 pm
Replies: 5
by RuSmolikova » Fri Aug 19, 2011 1:46 am

First post

The number of PML patients (MS sufferers treated with Tysabri) has raised from 145 at the beginning of July to 150 at the beginning of August. One...

Last post

Bingo! It´s easy to calculate.
As of the end of June 2010, Biogen Idec had approximately 52,700 patients on therapy, including about 600 in clinical...

5 Replies

2036 Views

Last post by HarryZ
Fri Aug 19, 2011 2:38 pm
Immune reconstitution inflammatory syndrome in natalizumab

Last post by MSUK « Wed Aug 17, 2011 1:04 am

by MSUK » Wed Aug 17, 2011 1:04 am

Immune reconstitution inflammatory syndrome in natalizumab-associated PML

Abstract
OBJECTIVE:
To study the outcome of patients with multiple...

0 Replies

1643 Views

Last post by MSUK
Wed Aug 17, 2011 1:04 am
FDA clears phase II trial of IkT-001 for JC virus infection

Last post by MSUK « Wed Aug 17, 2011 1:03 am

by MSUK » Wed Aug 17, 2011 1:03 am

Inhibikase Therapeutics, Inc., an emerging leader in infectious disease, announced today that it has received FDA clearance to commence a Phase II...

0 Replies

1467 Views

Last post by MSUK
Wed Aug 17, 2011 1:03 am
Tysabri and fertility

Last post by HarryZ « Wed Aug 10, 2011 8:52 am
Replies: 21
by AngelaO » Wed Feb 17, 2010 2:44 pm
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2
First post

I am 21 and going to be starting Tysabri. Im getting married in June and weve been discussing having children in the future. Ive heard some concerns...

Last post

ARTICLE:
Delivery of healthy babies after natalizumab use for multiple sclerosis: a
report of two cases
Acta Neurologica Scandinavica
I. A....
21 Replies

7712 Views

Last post by HarryZ
Wed Aug 10, 2011 8:52 am
SPASMS AND STIFFNESS

Last post by msmything « Tue Aug 09, 2011 9:39 am
Replies: 2
by numbness23 » Tue May 31, 2011 6:08 am

First post

Spasticity is my nemesis. Its controlling me. Baclofen seems to be doing nothing. Has anyone been in this boat and then improved once starting...

Last post

Hi, what do you mean when you say you've tried the injection?

2 Replies

1592 Views

Last post by msmything
Tue Aug 09, 2011 9:39 am
Tysabri rejection

Last post by msmything « Mon Aug 08, 2011 12:54 pm
Replies: 1
by Nosada » Thu Jun 16, 2011 6:34 pm

First post

From my doctors, I learned that shortness of breath is a major sign. I am sure they told me some others but I just do not remember.. Anyway I started...

Last post

Hi Nosada...I don't understand when you say you declined a little bit 1st month, then declined alot, ....what is declined?

1 Replies

1522 Views

Last post by msmything
Mon Aug 08, 2011 12:54 pm
Franks Tysabri exp., little sideeffects, no improvement

Last post by LR1234 « Sat Jul 16, 2011 11:49 am
Replies: 50
by Frank » Fri Jan 05, 2007 9:33 am
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First post

Hi,

I'm 30yo, EDSS around 2, currently 12 years with RRMS now. I live in germany and just got my 3rd Tysabri infusion.

I noticed mild...

Last post

Hi frank,
Just checking in with you to see how you are doing x
50 Replies

18272 Views

Last post by LR1234
Sat Jul 16, 2011 11:49 am
Whats going to happen if I miss an infusion?

Last post by gymbuff « Sun Jul 10, 2011 12:05 am
Replies: 4
by Sheldon425 » Wed Mar 30, 2011 3:50 pm

First post

Due to my Neuro moving away and the order for my Tysabri infusions running out at the end of the month. There is a chance I will miss my infusion...

Last post

Hi Guys

I had Tysabri Infusion 47 last Wednesday. It was 5 weeks since my previous infusion and I suffered no adverse effects. I never feel a slump...

4 Replies

6420 Views

Last post by gymbuff
Sun Jul 10, 2011 12:05 am
EC includes anti-JC virus antibody status as PML risk factor

Last post by MSUK « Tue Jun 21, 2011 11:09 pm

by MSUK » Tue Jun 21, 2011 11:09 pm

EC includes anti-JC virus antibody status as PML risk factor in Tysabri labeling

Biogen Idec Inc. and Elan Corporation, plc Wednesday said the...

0 Replies

1647 Views

Last post by MSUK
Tue Jun 21, 2011 11:09 pm
Drug dilemma for Multiple Sclerosis patients

Last post by MSUK « Tue Jun 21, 2011 12:58 am

by MSUK » Tue Jun 21, 2011 12:58 am

Patients must decide whether benefits of medication outweigh the risks of potentially fatal side effects

Faced with a debilitating and progressive...

0 Replies

1624 Views

Last post by MSUK
Tue Jun 21, 2011 12:58 am
1 death and 13 more cases of PML in Tysabri MS patients

Last post by HarryZ « Thu Jun 16, 2011 9:18 am
Replies: 1
by MSUK » Thu May 19, 2011 10:46 pm

First post

Biogen Idec Inc. reported 13 more cases of a rare brain infection occurring in multiple-sclerosis patients taking the drug Tysabri, sold with Elan...

Last post

These numbers can now be updated to 133 cases of PML. Don't know if there were any deaths included in the recent 9 additional patients.

Harry

1 Replies

1752 Views

Last post by HarryZ
Thu Jun 16, 2011 9:18 am
Age, time to diagnosis predict PML survival

Last post by MSUK « Mon Jun 06, 2011 7:58 am

by MSUK » Mon Jun 06, 2011 7:58 am

Younger age, faster diagnosis, and undergoing treatment in Europe were among the factors associated with greater likelihood of survival in cases of...

0 Replies

1612 Views

Last post by MSUK
Mon Jun 06, 2011 7:58 am
Gravely ill woman's husband is given pledges on co-operation

Last post by cheerleader « Tue May 31, 2011 7:42 am
Replies: 1
by MSUK » Fri May 27, 2011 2:15 am

First post

A Sligoman whose 41-year-old wife contracted an incurable deadly brain disease while using Elan's Tysabri multiple sclerosis treatment has received...

Last post

Here is information on the Deferno Trust--mentioned in this article.
Declan Walsh spoke passionately before the Elan board last week, asking for help...

1 Replies

2163 Views

Last post by cheerleader
Tue May 31, 2011 7:42 am
Tysabri-associated PML in MS: better survival rates

Last post by HarryZ « Thu May 19, 2011 5:49 am
Replies: 3
by MSUK » Wed May 18, 2011 11:24 pm

First post

Tysabri-associated PML in MS: better survival rates than other patient types

A follow-up study of 35 MS patients with Tysabri-associated...

Last post

The authors, 3 of whom work for Biogen Idec, the maker of Tysabri, admit that one major deficiency of their follow-up report is the lack of long-term...

3 Replies

1757 Views

Last post by HarryZ
Thu May 19, 2011 5:49 am
New Data Alter Natalizumab Safety Considerations in MS

Last post by Drury « Mon May 16, 2011 6:41 pm
Replies: 1
by scorpion » Sat May 14, 2011 11:03 am

1 Replies

1614 Views

Last post by Drury
Mon May 16, 2011 6:41 pm
IRIS and Tysabri

Last post by prof8 « Fri May 06, 2011 9:53 pm
Replies: 21
by Johnnymac » Thu Apr 01, 2010 4:04 pm
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2
First post

We had my wife's first visit with her Neuro since Sept of last year, at which time she discontinued her Tysabri infusions due to being at the 2 year...

Last post

My neuro recommended the following plan if I stop. Take 90 days to clear out Tysabri. On day 60 have 1 dose of IV 1,000 mg. steroids to protect from...
21 Replies

9872 Views

Last post by prof8
Fri May 06, 2011 9:53 pm
7 more PML infections, 1 more death in Tysabri MS patients

Last post by HarryZ « Thu May 05, 2011 5:49 am
Replies: 2
by MSUK » Fri Mar 18, 2011 11:55 pm

First post

Biogen Idec Inc. reported 7 more cases of a rare brain infection among multiple sclerosis patients taking Tysabri, sold with Elan Corp. bringing the...

Last post

Just read per the link below that the number of PML cases has risen to 121.

Harry

2 Replies

1965 Views

Last post by HarryZ
Thu May 05, 2011 5:49 am
New MSRC Tysabri Diary Updates

Last post by MSUK « Thu May 05, 2011 1:14 am

by MSUK » Thu May 05, 2011 1:14 am

New MSRC Tysabri Diary Updates

I would like to welcome Kara as our newest Tysabri Diarist and also thank Kirsty and Fabiola for updating their...

0 Replies

1682 Views

Last post by MSUK
Thu May 05, 2011 1:14 am
Natalizumab therapy in patients of African descent

Last post by MSUK « Tue May 03, 2011 5:23 am

by MSUK » Tue May 03, 2011 5:23 am

Efficacy of Natalizumab therapy in patients of African descent With RRMS

Summary
Patients of African descent often experience a more aggressive...

0 Replies

2062 Views

Last post by MSUK
Tue May 03, 2011 5:23 am

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