Tysabri (Antegren or Natalizumab)

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FDA: Tysabri risks greatest during year 3

Last post by MSUK « Mon Apr 25, 2011 11:29 pm

by MSUK » Mon Apr 25, 2011 11:29 pm

The FDA has updated its warning on Biogen Idec's multiple sclerosis drug Tysabri. According to the agency, the risk of a potentially fatal brain...

0 Replies

1572 Views

Last post by MSUK
Mon Apr 25, 2011 11:29 pm
Tysabri users may want to check this one out

Last post by HarryZ « Thu Apr 21, 2011 5:46 pm
Replies: 17
by Pink2010 » Thu Oct 21, 2010 8:49 am
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First post

Bernstein's Porges estimates the risk (of PML) jumps to 1-in-400 patients after three years of use.

Please note: I do not judge you if you are...

Last post

I am anything but sad........what is sad is that many spend a small fortune on this treatment.. then were told.......they needed to change their diet...
17 Replies

4185 Views

Last post by HarryZ
Thu Apr 21, 2011 5:46 pm
Does anyone know of a way off tysabri without rebound

Last post by stillfighting « Tue Apr 19, 2011 10:11 pm
Replies: 7
by Pink2010 » Thu Oct 21, 2010 8:22 am

First post

I have tried to get my neuro to take me off tysabri since the first year I was on it. Each time I am told no. Each time I tell them I am sick in bed...

Last post

Yes I think another dr too. If my dr does not think something is a good option for me.. they need to tell me why................but the choice is...

7 Replies

2957 Views

Last post by stillfighting
Tue Apr 19, 2011 10:11 pm
CHMP recommends updating Tysabri labeling with anti-JC virus

Last post by MSUK « Sun Apr 17, 2011 11:39 pm

by MSUK » Sun Apr 17, 2011 11:39 pm

Biogen Idec and Elan Corporation, plc announced that the Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for...

0 Replies

1446 Views

Last post by MSUK
Sun Apr 17, 2011 11:39 pm
Test finds Tysabri patients with 1% brain disease risk

Last post by HarryZ « Fri Apr 15, 2011 6:11 am
Replies: 1
by MSUK » Fri Apr 15, 2011 1:07 am

First post

Biogen Idec Inc. has identified high-risk patients taking its multiple sclerosis drug Tysabri who have a 1 in 100 chance of developing a potentially...

Last post

Squiff...you just keep coming up with all these reports...great stuff..thanks.

While this report paints a brighter picture for potential Tysabri...

1 Replies

1852 Views

Last post by HarryZ
Fri Apr 15, 2011 6:11 am
Biogen halts enrollment In Tysabri trial, citing slow pace

Last post by sou « Tue Apr 12, 2011 8:04 am
Replies: 27
by MSUK » Tue Mar 15, 2011 11:25 pm
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First post

Biogen Idec Inc. has halted enrollment in a large, long-term clinical trial aimed at testing the earlier use of multiple sclerosis drug Tysabri,...

Last post

LOL! So it seems that they are fully capable of making themselves look untrustworthy. They don't need fear-mongerers to help them.
27 Replies

3993 Views

Last post by sou
Tue Apr 12, 2011 8:04 am
MS drug Tysabri label updated to include PML incidence

Last post by MSUK « Sun Apr 10, 2011 2:54 am

by MSUK » Sun Apr 10, 2011 2:54 am

The label of multiple sclerosis drug Tysabri, sold by Biogen Idec Inc. (BIIB) and Elan Corp. (ELN), has been changed to include the updated incidence...

0 Replies

1561 Views

Last post by MSUK
Sun Apr 10, 2011 2:54 am
I have the Infection....

Last post by MicheleF « Sun Apr 03, 2011 7:36 pm
Replies: 8
by ShakyJay » Sun Jan 30, 2011 12:58 am

First post

So I just returned from my Neuro out in Colorado, and it is official... I have the rare brain infection.

I have only been on Tysabri for a little...

Last post

I am so sorry of your news. I am still unsure what it means to have PML. I am on my 5th infusion and worry about this daily. Would you please post...

8 Replies

3253 Views

Last post by MicheleF
Sun Apr 03, 2011 7:36 pm
Potential test for PML risk - Tysabri gets Europe approval

Last post by HarryZ « Fri Mar 11, 2011 8:35 am
Replies: 1
by MSUK » Tue Mar 08, 2011 11:44 pm

First post

Biogen Idec Inc.'s diagnostic test that may help determine the risk of developing a rare brain infection in patients using multiple sclerosis drug...

Last post

Biogen Idec Inc.'s diagnostic test that may help determine the risk of developing a rare brain infection in patients using multiple sclerosis drug...

1 Replies

1759 Views

Last post by HarryZ
Fri Mar 11, 2011 8:35 am
MHRA issues MS treatment risk update

Last post by HarryZ « Fri Mar 04, 2011 9:01 am
Replies: 1
by MSUK » Fri Mar 04, 2011 6:22 am

First post

Risk of progressive multifocal leukoencephalopathy (PML) is increased in patients receiving natalizumab (Tysabri) who have had previous...

Last post

Risk of progressive multifocal leukoencephalopathy (PML) is increased in patients receiving natalizumab (Tysabri) who have had previous...

1 Replies

1406 Views

Last post by HarryZ
Fri Mar 04, 2011 9:01 am
MSRC Tysabri Diary Update - Fabiola

Last post by MSUK « Tue Mar 01, 2011 1:13 am

by MSUK » Tue Mar 01, 2011 1:13 am

MSRC Tysabri Diary Update

Fabiola has kindly sent in her latest Tysabri Diary update, you can read her new entry at

0 Replies

1717 Views

Last post by MSUK
Tue Mar 01, 2011 1:13 am
Tysabri and cold sores

Last post by HarryZ « Fri Feb 25, 2011 11:24 am
Replies: 1
by Reeny » Thu Feb 24, 2011 7:39 pm

First post

Hi I'm new here. I have been on Tysabri for 14 months. Last month I developed a few cold sores in my mouth. That is nothing new for me I've had them...

Last post

Hi I'm new here. I have been on Tysabri for 14 months. Last month I developed a few cold sores in my mouth. That is nothing new for me I've had them...

1 Replies

2505 Views

Last post by HarryZ
Fri Feb 25, 2011 11:24 am
10 more PML infections, 4 more deaths in Tysabri MS patients

Last post by HarryZ « Wed Feb 23, 2011 1:46 pm
Replies: 4
by MSUK » Fri Feb 18, 2011 12:55 am

First post

Biogen Idec Inc. disclosed 10 more cases of a rare brain infection among multiple sclerosis patients taking Tysabri, a medication it sells with Elan...

Last post

Biogen knew when they made the decision to produce this webcast that they would be in violation, but they didn't care. Over four months after the...

4 Replies

2113 Views

Last post by HarryZ
Wed Feb 23, 2011 1:46 pm
Weight gain with Tysabri?

Last post by T19 « Tue Feb 08, 2011 5:59 pm
Replies: 1
by CCSVIAnaMaria » Fri Sep 03, 2010 8:14 am

First post

Hi everyone,

My mother started Tysabri about a year and a half ago. She didn't get any improvement in her symptoms.

We think that she started...

Last post

I had no weight gain from Tysabri but did with steriods. They are a culprit in weight gain but so are some others meds commonly used by MS patients....

1 Replies

2558 Views

Last post by T19
Tue Feb 08, 2011 5:59 pm
Infusion versus medication

Last post by kda « Sat Jan 29, 2011 6:52 am
Replies: 2
by kda » Fri Jan 28, 2011 9:27 am

First post

Anthem BC/BS will only cover $5k a year on my prescription Avonex. It costs around $3k a month!! I am noticing online that this is also true for...

Last post

Oh, yes, I'm well aware of Biogen's financial aid dept. They are wonderful people to talk to, but they can't help me. I have a prescription drug...

2 Replies

1665 Views

Last post by kda
Sat Jan 29, 2011 6:52 am
Pregnancy and tysabri

Last post by HarryZ « Tue Jan 25, 2011 6:50 am
Replies: 1
by AmesB97 » Tue Jan 25, 2011 5:11 am

First post

Does anyone know much about pregnancy and tysabri? My nuro says its not ideal but ok but i have read so many other info and im very stressed

Last post

Does anyone know much about pregnancy and tysabri? My nuro says its not ideal but ok but i have read so many other info and im very stressed

I have...

1 Replies

1946 Views

Last post by HarryZ
Tue Jan 25, 2011 6:50 am
6 more cases of PML brain infection in Tysabri MS patients

Last post by hwebb « Fri Jan 21, 2011 12:36 pm
Replies: 1
by MSUK » Thu Jan 20, 2011 11:47 pm

First post

Biogen Idec Inc. disclosed six more cases of a rare brain infection in multiple sclerosis patients taking Tysabri, a medication it sells with Elan...

Last post

it's covered by Reuters too:

1 Replies

1788 Views

Last post by hwebb
Fri Jan 21, 2011 12:36 pm
20th tysabri

Last post by annbbe « Fri Jan 21, 2011 11:27 am

by annbbe » Fri Jan 21, 2011 11:27 am

Hi, i am on Tysabri since jan. 2009. I don't take it regularly - lack of money... I had one 3 month period of drug vacation, i took drug after 2...

0 Replies

1464 Views

Last post by annbbe
Fri Jan 21, 2011 11:27 am
New Facebook Group to Network Tysabri PML Patients

Last post by japentz « Thu Jan 13, 2011 6:54 am
Replies: 3
by japentz » Wed Jan 12, 2011 6:02 am

First post

A group has been started by Declan Walsh, husband of Natalie who now has PML due to use of Tysabri. If you know of someone affected by PML due to...

Last post

Please try it again. I just clicked on it and it went right to the page. It contained the following information.

List of PML diseases under Tysabri...

3 Replies

2511 Views

Last post by japentz
Thu Jan 13, 2011 6:54 am
Tysabri Multiple Sclerosis treatment launched in India

Last post by MSUK « Tue Dec 28, 2010 11:50 pm

by MSUK » Tue Dec 28, 2010 11:50 pm

In continuation of its commitment to Multiple Sclerosis (MS) patients in India, Biogen Idec has introduced Tysabri (natalizumab), the first...

0 Replies

2446 Views

Last post by MSUK
Tue Dec 28, 2010 11:50 pm
4 more PML infections, 1 more death in Tysabri MS patients

Last post by HarryZ « Thu Dec 23, 2010 6:53 am
Replies: 6
by MSUK » Thu Dec 16, 2010 11:34 pm

First post

Biogen Idec Inc. disclosed four more cases of a rare brain infection in multiple sclerosis patients on Tysabri, which it sells with Elan Corp. (ELN),...

Last post

Brave men...

Biogen and Elan see that the number of Tysabri users appears to have remained stagnant as the PML risk increases and the oral MS...

6 Replies

2108 Views

Last post by HarryZ
Thu Dec 23, 2010 6:53 am
Tysabri may reduce axonal damage

Last post by concerned « Wed Dec 22, 2010 1:14 pm
Replies: 14
by bromley » Mon Dec 20, 2010 1:37 pm

First post

Note: please keep this quiet - I don't want Harry Z to find out as it may spoil his Christmas!

Last post

I was just wondering about the 2012 thing.
Damned skeptics would have to notice that! :lol: :oops:

At this point I can't say whether that was a...

14 Replies

2425 Views

Last post by concerned
Wed Dec 22, 2010 1:14 pm
Tysabri labeling changes submitted to help stratify PML risk

Last post by MSUK « Wed Dec 22, 2010 12:47 am

by MSUK » Wed Dec 22, 2010 12:47 am

Biogen Idec and Elan Corporation, plc have announced that the companies have submitted a supplemental Biologics License Application (sBLA) to the...

0 Replies

1637 Views

Last post by MSUK
Wed Dec 22, 2010 12:47 am
Potential treatment for PML announced

Last post by MSUK « Tue Nov 30, 2010 3:43 am

by MSUK » Tue Nov 30, 2010 3:43 am

Potential treatment for progressive multifocal leukoencephalopathy (PML) announced

Cytheris Announces Publication of Clinical Case Study...

0 Replies

1643 Views

Last post by MSUK
Tue Nov 30, 2010 3:43 am
5 more cases of PML brain infection in Tysabri MS patients

Last post by MSUK « Thu Nov 18, 2010 12:22 am

by MSUK » Thu Nov 18, 2010 12:22 am

Biogen Idec Inc. disclosed five more cases of a rare brain infection in multiple sclerosis patients on Tysabri, which it sells with Elan Corp. (ELN),...

0 Replies

1664 Views

Last post by MSUK
Thu Nov 18, 2010 12:22 am
PML risk goes down after 3 years. Anybody else heard this?

Last post by HarryZ « Sun Nov 14, 2010 7:02 am
Replies: 2
by DenverCO » Thu Nov 11, 2010 12:09 pm

First post

I had my blood drawn to check for the JCV antibody. I was told that the results are coming back 50/50, but that there is evidence that the patients...

Last post

I had my blood drawn to check for the JCV antibody. I was told that the results are coming back 50/50, but that there is evidence that the patients...

2 Replies

1853 Views

Last post by HarryZ
Sun Nov 14, 2010 7:02 am
Lay offs at Biogen and new lawsuit--

Last post by dreddk « Wed Nov 10, 2010 11:15 pm
Replies: 1
by cheerleader » Wed Nov 03, 2010 10:31 am

First post

Biogen announced today it is laying off 13% of its work force

Biotechnology company Biogen Idec Inc. said Wednesday it is laying off 13 percent...

Last post

Gilenya will hurt Tysabri big time (I actually considered shorting their stock a few months ago). Anyone prepared to take the Tysabri risk will...

1 Replies

2289 Views

Last post by dreddk
Wed Nov 10, 2010 11:15 pm
Four more cases of PML and two more deaths reported -Tysabri

Last post by Bodie « Tue Oct 26, 2010 8:54 pm
Replies: 31
by MSUK » Fri Apr 16, 2010 6:52 am
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First post

Four more cases of PML and two more deaths reported for Tysabri -

Last post

It is why they are starting a JCV test for all the Ty people here. If you have the virus you are done w/ Ty I believe.

The wiki for PML says IT IS...
31 Replies

7965 Views

Last post by Bodie
Tue Oct 26, 2010 8:54 pm
mewly diagnosed, starting tysabri?

Last post by Drury « Mon Oct 25, 2010 5:26 pm
Replies: 9
by downtowner » Thu Sep 09, 2010 5:56 am

First post

Hi,

I was diagosed with MS in febuary this year. I've been on copaxone ever since. At my last neuro apointment I was told that copaxone is not...

Last post

Bodie,

Have you had regular checks for JCV antibodies or is this a new test? How do they test you is it via a spinal tap? Is this the first time you...

9 Replies

2489 Views

Last post by Drury
Mon Oct 25, 2010 5:26 pm
Tysabri and the flu shot.

Last post by TWG « Thu Oct 21, 2010 1:53 pm
Replies: 3
by TWG » Fri Oct 15, 2010 5:56 am

First post

At my last infusion they asked if I wanted the annual flu shot. A different nurse said that I should not because tysabri would cause the flu shot to...

Last post

Last infusion was October 8, next is November 19.. I had one last year and was no big deal. I just can't afford to get the flu. Since I got answers...

3 Replies

3128 Views

Last post by TWG
Thu Oct 21, 2010 1:53 pm
MS-related fatigue improves more with Tysabri

Last post by HarryZ « Thu Oct 21, 2010 9:58 am
Replies: 3
by MSUK » Tue Oct 19, 2010 9:55 pm

First post

The prevalence and severity of fatigue in patients with relapsing-remitting multiple sclerosis (RRMS) are more reduced during treatment with...

Last post

I have a real problem believing this. My fatigue is so much worse then before I went on this drug. Most of the people I see at the infusion center...

3 Replies

1886 Views

Last post by HarryZ
Thu Oct 21, 2010 9:58 am
Stopping Natalizumab Causes Inflammatory Rebound in MS

Last post by HarryZ « Tue Oct 19, 2010 7:04 am
Replies: 1
by scorpion » Tue Oct 12, 2010 1:37 pm

First post

Something else to think about before starting treatment:

Last post

Something else to think about before starting treatment:

Hmmm....24 RR patients and 8 SP...not exactly a lot of patients for any trial. What we...

1 Replies

1955 Views

Last post by HarryZ
Tue Oct 19, 2010 7:04 am
New MRI criteria have high efficiency in MS

Last post by MSUK « Fri Oct 15, 2010 11:57 pm

by MSUK » Fri Oct 15, 2010 11:57 pm

New criteria for diagnosing multiple sclerosis with a single MRI have a sensitivity of up to 86% and a specificity of up to 75%, researchers said...

0 Replies

1536 Views

Last post by MSUK
Fri Oct 15, 2010 11:57 pm
Data further supporting anti-JC virus antibody assay

Last post by MSUK « Fri Oct 15, 2010 11:22 pm

by MSUK » Fri Oct 15, 2010 11:22 pm

Biogen Idec and Elan Corporation, plc announced data further supporting the potential clinical utility of an investigational assay that detects...

0 Replies

1644 Views

Last post by MSUK
Fri Oct 15, 2010 11:22 pm
Results support possible benefits of Tysabri for MS patients

Last post by HarryZ « Fri Oct 08, 2010 5:27 am
Replies: 1
by MSUK » Fri Oct 08, 2010 2:14 am

First post

Biogen Idec and Elan Corporation, plc have announced six-month results of an ongoing, one-year longitudinal, observational, patient-reported outcomes...

Last post

Healthcore is a large shareholder in Biogen/Idec and less than a year ago, publicly attacked James Mullen, Biogen's CEO, for selling massive amounts...

1 Replies

1621 Views

Last post by HarryZ
Fri Oct 08, 2010 5:27 am
MSRC Tysabri Diaries - 3rd year diary update

Last post by MSUK « Fri Sep 24, 2010 2:15 am

by MSUK » Fri Sep 24, 2010 2:15 am

Christine has kindly sent in her 3 year dosing anniversary diary entry for her Tysabri Diary.

You can read this here

If you are thinking of being...

0 Replies

1669 Views

Last post by MSUK
Fri Sep 24, 2010 2:15 am
2 Tysabri Amps for sale (Poland, Czech Republic, E. Germany)

Last post by greyman « Wed Sep 22, 2010 10:38 pm

by greyman » Wed Sep 22, 2010 10:38 pm

Hello
Because of some allegric reactions after my 23rd Tysabri infusion (bruises on calves) I had to stop taking it. The problem is that I still have...

0 Replies

1496 Views

Last post by greyman
Wed Sep 22, 2010 10:38 pm
MSRC Tysabri Diaries - New Diary added

Last post by MSUK « Mon Sep 20, 2010 11:34 pm

by MSUK » Mon Sep 20, 2010 11:34 pm

Ade has kindly joined the MSRC's Tysabri Users Panel and has sent in his first diary update.

You can read Ade's diary at

If you are thinking of...

0 Replies

1644 Views

Last post by MSUK
Mon Sep 20, 2010 11:34 pm
Balancing the risks of Tysabri dosing holidays

Last post by MSUK « Sun Sep 19, 2010 10:57 pm

by MSUK » Sun Sep 19, 2010 10:57 pm

A new study may help clinicians balance the risks and potential benefits of suspending natalizumab dosing in patients with relapsing multiple...

0 Replies

1556 Views

Last post by MSUK
Sun Sep 19, 2010 10:57 pm
Safety and efficacy of natalizumab in children with MS

Last post by MSUK « Thu Sep 16, 2010 4:56 am

by MSUK » Thu Sep 16, 2010 4:56 am

Abstract

OBJECTIVE: To describe the effect of natalizumab in the treatment of subjects with active multiple sclerosis (MS) treated before the age of...

0 Replies

1453 Views

Last post by MSUK
Thu Sep 16, 2010 4:56 am
5 more cases of brain infection and 2 more deaths In Tysabri

Last post by indigoinmotion « Wed Sep 15, 2010 5:35 am
Replies: 1
by MSUK » Wed Sep 15, 2010 3:57 am

First post

5 more cases of brain infection and 2 more deaths In Tysabri MS patients

Biogen Idec Inc. disclosed five more cases of a rare brain infection in...

Last post

oh my! when I first started to consider going on Tysabri in May of this year, the number was a lot lower. Now, I'm really worried! Thanks for...

1 Replies

1748 Views

Last post by indigoinmotion
Wed Sep 15, 2010 5:35 am
Tysabri drug holiday in multiple sclerosis poorly tolerated

Last post by catfreak « Sat Sep 11, 2010 7:32 pm
Replies: 4
by MSUK » Wed Jul 28, 2010 11:52 pm

First post

Abstract

It has been suggested that natalizumab-associated progressive multifocal leukoencephalopathy may be prevented by structured interruptions...

Last post

I have been off Tysabri for 7+ months with no problem yet!!

Cat

4 Replies

2403 Views

Last post by catfreak
Sat Sep 11, 2010 7:32 pm
MSRC Tysabri User Diaries - Update by Tony

Last post by MSUK « Mon Sep 06, 2010 12:51 am

by MSUK » Mon Sep 06, 2010 12:51 am

Tony has added a new update to his Tysabri Diary, you can read his latest entry at

0 Replies

1580 Views

Last post by MSUK
Mon Sep 06, 2010 12:51 am
Tysabri stay on or go off?

Last post by HarryZ « Fri Aug 27, 2010 5:50 am
Replies: 2
by tiffywebb » Mon Aug 23, 2010 2:51 pm

First post

I just recently got liberated and I have been on Tysabri for 27 infusions. My ms was very aggressive from the onstart and Tysabri is the only drug...

Last post

tiffywebb,

Congratulation on your liberation!

I understand you dilemma but you need to tell your neuro. If you are on blood thinners they will have...

2 Replies

1738 Views

Last post by HarryZ
Fri Aug 27, 2010 5:50 am
5 more cases of PML brain infection in Tysabri MS patients

Last post by HarryZ « Sun Aug 22, 2010 2:38 pm
Replies: 1
by MSUK » Wed Aug 18, 2010 11:35 pm

First post

Biogen Idec Inc. disclosed five more cases of a rare brain infection in multiple sclerosis patients on Tysabri, which it sells with Elan Corp....

Last post

Biogen Idec Inc. disclosed five more cases of a rare brain infection in multiple sclerosis patients on Tysabri, which it sells with Elan Corp....

1 Replies

1790 Views

Last post by HarryZ
Sun Aug 22, 2010 2:38 pm
MSRC Tysabri User Diary Update - Tony

Last post by MSUK « Thu Aug 12, 2010 1:45 am

by MSUK » Thu Aug 12, 2010 1:45 am

Tony has kindly sent in his update on his 30th Tysabri infusion.

You can read Tony's newest update at

If you are thinking of having Tysabri...

0 Replies

1690 Views

Last post by MSUK
Thu Aug 12, 2010 1:45 am
JC Virus

Last post by chrishasms « Wed Jul 28, 2010 3:32 pm
Replies: 4
by chrishasms » Fri Jul 23, 2010 10:06 am

First post

Tested positive for it. Done with Ty after next infusion.

Last post

Nah and I just wanted to be doing something rather than nothing or taking Copaxone like everyone else. But they were running a research program here...

4 Replies

1950 Views

Last post by chrishasms
Wed Jul 28, 2010 3:32 pm
PML Effects?

Last post by NHE « Tue Jul 27, 2010 6:41 pm

by NHE » Tue Jul 27, 2010 6:41 pm

Of all the people who have developed PML, but have not died, how many have experienced in increase in disability due to the PML and to what extent...

0 Replies

1522 Views

Last post by NHE
Tue Jul 27, 2010 6:41 pm
Biogen corrects the Tysabri label (in US only)

Last post by Drury « Tue Jul 27, 2010 1:23 pm
Replies: 3
by RuSmolikova » Fri Jul 23, 2010 3:58 am

First post

Source: Reuters
The company said on a conference call (20th oh July 2010) with investors that it has updated the Tysabri label to show the risk of...

Last post

RuSmolikova,

Thank you very much for that very informative information.

Really apprecaite your feedback.

Drury

3 Replies

1958 Views

Last post by Drury
Tue Jul 27, 2010 1:23 pm
MSRC Tysabri Diaries - Update by Michelle

Last post by MSUK « Mon Jul 26, 2010 1:21 am

by MSUK » Mon Jul 26, 2010 1:21 am

Michelle has kindly sent in her latest Tysabri Diary update, you can read this at

0 Replies

1663 Views

Last post by MSUK
Mon Jul 26, 2010 1:21 am

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