A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis
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Coronavirus (COVID-19): What You Need To Know
Replies: 132
by
jimmylegs » Sun Mar 15, 2020 4:10 am » in
General Discussion
First post
What You Need To Know About Coronavirus (COVID-19)
What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...
Last post
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 (June 3)
...
CONCLUSIONS
After high-risk or moderate-risk...
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Last post by jimmylegs
Wed Jun 03, 2020 6:36 pm
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Last post by MSUK
Tue Sep 30, 2014 2:00 am
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PML Cases now at 475
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HarryZ » Mon Jul 28, 2014 4:56 am
The number of Tysabri related PML cases rose by 3 in the past month to 475. Don't know if this means they are screening Tysabri users better before...
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Last post by HarryZ
Mon Jul 28, 2014 4:56 am
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Last post by MSUK
Wed Jul 23, 2014 1:39 am
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Tysabri in India
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MSKarena » Wed Jul 09, 2014 10:52 am
I am getting ready to start Tysabri due to the fact that I have failed copaxone and rebif now. I am also getting ready to do a year in India(6 months...
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Last post by MSKarena
Wed Jul 09, 2014 10:52 am
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Last post by MSUK
Wed Jul 02, 2014 1:45 am
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- 2352 Views
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Last post by MSUK
Thu Jun 26, 2014 12:49 am
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PML cases now at 472
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HarryZ » Sun Jun 22, 2014 4:18 am
The number of officially reported Tysabri related PML cases has climbed to 472, an increase of 8 from the previous month. Don't know if any more...
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- 2401 Views
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Last post by HarryZ
Sun Jun 22, 2014 4:18 am
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Study suggests Tysabri safe past 24 months
Replies: 1
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MSUK » Fri Jun 13, 2014 12:54 am
First post
Study suggests MS drug Tysabri treatment can be safely continued past 24 months
A recent study suggests that treatment with natalizumab (Tysabri)...
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Dr. Myhr has received honoraria for lecturing; participation in advisory boards or pharmaceutical company–sponsored clinical trials; and travel...
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Last post by HarryZ
Fri Jun 13, 2014 10:24 am
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MS rebound after stopping Tysabri
Replies: 2
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MSUK » Mon Jun 09, 2014 12:54 am
First post
Abnormal inflammatory activity returns after natalizumab cessation in multiple sclerosis.
Gueguen A, Roux P, Deschamps R, Moulignier A, Bensa C,...
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Kind of places the potential Tysabri user in a difficult position....use the drug for more than 2 years and see the risk of PML climb higher and...
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Last post by HarryZ
Mon Jun 09, 2014 11:46 am
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Age and it's effects on response to MS treatment Tysabri
Replies: 1
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MSUK » Fri Jun 06, 2014 12:44 am
First post
Age-dependent effects on the treatment response of natalizumab in MS patients.
Matell H, Lycke J, Svenningsson A, Holmén C, Khademi M, Hillert J,...
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I guess it isn't surprising that Tysabri has little effect, if any, on older MS patients.
While the immune system appears to react to inflammation...
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- 2356 Views
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Last post by HarryZ
Fri Jun 06, 2014 6:32 am
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- 5 Replies
- 2736 Views
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Last post by bonzo
Tue Jun 03, 2014 11:23 am
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PML Cases now Reach 464
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HarryZ » Sat May 31, 2014 4:30 am
The number of reported PML cases from using Tysabri has jumped by 10 up to 464. Certainly not seeing any slowdown in this area. Don't know if any...
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- 1818 Views
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Last post by HarryZ
Sat May 31, 2014 4:30 am
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The RESTORE trial: What did we learn about MS?
Replies: 1
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MSUK » Tue May 13, 2014 11:07 pm
First post
RESTORE was a randomized, partially placebo-controlled exploratory study evaluating multiple sclerosis (MS) disease activity during a 24-week...
Last post
RESTORE was a randomized, partially placebo-controlled exploratory study evaluating multiple sclerosis (MS) disease activity during a 24-week...
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Last post by HarryZ
Thu May 15, 2014 7:12 am
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New Data for MS drug Tysabri released at AAN annual meeting
Replies: 1
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MSUK » Thu May 01, 2014 5:35 am
First post
- New Tysabri® analysis shows improved walking speed in significant number of MS patients.
- Additional data show escalation to Tysabri following...
Last post
- New Tysabri® analysis shows improved walking speed in significant number of MS patients.
- Additional data show escalation to Tysabri following...
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- 2140 Views
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Last post by HarryZ
Thu May 01, 2014 6:59 pm
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Tysabri to start soon......
Replies: 13
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mpalla » Fri Dec 13, 2013 5:48 pm
First post
My neuro wants me to start Tysabri. I have done all kinds of research and read on this page. My thoughts have been scrambled on this issue for days....
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Thanks Anonymoose! I'd feel the new norm if I didn't have a cold. I'm impressed with my neuro and the drug. Will update you. Thanks again!
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- 2683 Views
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Last post by mpalla
Sat Apr 26, 2014 5:37 am
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PML Cases now reach 454!
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HarryZ » Mon Apr 21, 2014 3:57 pm
The number of reported PML cases has risen 6 more to 454. Don't know if any deaths are included in this number.
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- 1766 Views
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Last post by HarryZ
Mon Apr 21, 2014 3:57 pm
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New clues to link between MS drug Tysabri and PML
Replies: 3
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MSUK » Wed Mar 26, 2014 8:55 am
First post
Researchers report drug mobilizes a kind of cell easily infected by a virus that attacks the brain.
Researchers report that they think they have...
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This is out of left field but I wonder if those same B cells that are susceptible to jcv infection are also susceptible to ebv infection. If ebv...
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Last post by Anonymoose
Thu Mar 27, 2014 7:16 am
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PML Cases Now Reach 448
by
HarryZ » Sat Mar 22, 2014 5:57 am
The number of Tysabri related PML cases has increased by 9 over the previous month, bringing the new total to 438. It isn't known if there are any...
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- 1669 Views
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Last post by HarryZ
Sat Mar 22, 2014 5:57 am
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Tysabri is a dangerous drug
Replies: 5
by
Andromeda » Fri Mar 14, 2014 9:10 am
First post
Brief background, I used to work in the FDA program that handled drugs monitored under the Risk Evaluation and Mitigation Strategy program. The FDA...
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Yeah...there are certainly more cases of PML than have actually been reported. You would think that the TOUCH program would capture most cases, but...
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Last post by centenarian100
Wed Mar 19, 2014 9:37 pm
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No definite melanoma link for Tysabi...
Replies: 1
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MSUK » Wed Mar 19, 2014 7:23 am
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Australian regulator finds no definite melanoma link for Tysabri
Australia’s Therapeutic Goods Administration (TGA) revealed today that it is...
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MSUK, are you affiliated directly or indirectly with any pharmaceutical organisations :?:
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Last post by THX1138
Wed Mar 19, 2014 9:53 am
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MS-UK Tysabri User Diaries
Replies: 9
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MSUK » Wed Feb 06, 2013 8:04 am
First post
MS-UK Tysabri Diary Update
Kirsty has kindly sent in her 25th Tysabri Infusion Diary update.
You can read it at
Last post
MS-UK Tysabri Diary Update
Nicki has kindly sent in her next Tysabri diary update.
You can read it at h ttp://www.ms-uk.org/nicki
- 9 Replies
- 3073 Views
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Last post by MSUK
Wed Mar 12, 2014 3:33 am
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PML Cases now reach 439!
Replies: 7
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HarryZ » Mon Feb 24, 2014 11:11 am
First post
Last month the number of Biogen reported Tysabri related cases jumped by 9 making the new total 439. Don't know if any more deaths are included in...
Last post
Thanks Cheer,
I was going to mention these other numbers in my post but got involved in a phone call and forgot. That's what happens when you get...
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- 1947 Views
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Last post by HarryZ
Sat Mar 01, 2014 8:44 am
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Efficacy and safety of natalizumab in multiple sclerosis
Replies: 5
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MSUK » Fri Feb 21, 2014 3:20 am
First post
Efficacy and safety of natalizumab in multiple sclerosis: interim observational programme results
Abstract
BACKGROUND: Clinical trials established...
Last post
I think the missing numbers may be partially made up of those that came up as JCV positive, and hence advised to stop taking it, but not technically...
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Last post by HarryZ
Sat Feb 22, 2014 6:30 am
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HIV drug may help in PML
Replies: 1
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MSUK » Fri Jan 31, 2014 2:56 am
First post
A relatively simple way to make progressive multifocal leukoencephalopathy (PML) more survivable appears to have worked in a multiple sclerosis...
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Hey!!! That is my doctor who wrote in the NEJM! I sure hope I never need his expertise in treating PML.
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Last post by sophie447
Sat Feb 08, 2014 9:21 am
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PML cases now reach 430
Replies: 13
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HarryZ » Sat Jan 25, 2014 8:39 am
First post
Latest reported cases of PML has risen by 7 last month to 430. Not known if any more related deaths.
Last post
This was news to me:
Unfortunately, the sudden removal of natalizumab often triggers a condition called immune reconstitution inflammatory syndrome...
- 13 Replies
- 2458 Views
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Last post by CureOrBust
Fri Jan 31, 2014 6:38 pm
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JCV index
Replies: 8
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pballer76 » Fri Nov 29, 2013 5:58 am
First post
I am JCV+. I used tysabri 73 times. I switched to tecfidera, used it for 4 months.
My neuro had me stop taking it. I had 1 flare and developed...
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I don't think the word trust and Biogen belong in the same sentence.
haha...perhaps not. I don't think I would give Novartis or Teva much trust...
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Last post by HarryZ
Thu Jan 09, 2014 8:51 am
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Sister just diagnosed with PML
Replies: 5
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lovemysis » Thu Jun 20, 2013 7:28 pm
First post
Hi!
My sister was just diagnosed with PML on Monday and I am just looking for another individuals who have gone through this! If anyone can point me...
Last post
So sorry.
I hope she is doing ok. I don't know much about living with PML, but a woman that is on utube contracted PML. She used to make lots of...
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Last post by centenarian100
Mon Dec 23, 2013 10:07 pm
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PML cases now reach 423
Replies: 4
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HarryZ » Fri Dec 20, 2013 10:44 am
First post
PML cases have jumped 5 more from last month...up to 523. Not known if any additional deaths took place.
Last post
Thanks Cheer...
As usual, you've done your research!
It would be nice for every potential Tysabri patient be given this kind of information but we...
- 4 Replies
- 1933 Views
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Last post by HarryZ
Sat Dec 21, 2013 1:22 pm
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Rebound
Replies: 2
by
Allstar22 » Fri Dec 20, 2013 2:23 am
First post
I'm new to the forum but I'm currently on tecfidera and have been on it for 4 months. I was on Gilenya and didn't have any relapses but decided to...
Last post
I read recently that neurologists were only placing people on Tysabri for a maximum of 18-14 months regardless of their JCV status. So if this is...
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- 1732 Views
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Last post by CureOrBust
Fri Dec 20, 2013 5:51 am
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relapse or something worse?
Replies: 3
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Mixobarbaros » Tue Dec 03, 2013 10:28 pm
First post
Hello all, I am brand new to the community. I was diagnosed with relapse/remitting MS in 2008. After a year or so on Copaxone, I got lazy and stopped...
Last post
Thanks, Cheer!
Yesterday I felt fatigue like never before. Today, it's not as bad.
I will definitely forward these questions to my neuro and will...
- 3 Replies
- 1845 Views
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Last post by Mixobarbaros
Thu Dec 05, 2013 9:46 am
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PML Cases now reach 418
by
HarryZ » Sat Nov 23, 2013 11:45 am
As of November 5, there are now 418 known cases of PML, 8 more than from the previous month. Don't know if there are any more deaths.
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- 1562 Views
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Last post by HarryZ
Sat Nov 23, 2013 11:45 am
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Need Name of Doctor for PML Management and Treatment ASAP
Replies: 18
by
UncleB » Thu May 09, 2013 5:36 pm
First post
Has anyone had current or recent experience with PML?
Whom, in addition to Biogen, should be contacted for consultation for PML management and...
Last post
It is difficult to differentiate between PML and an MS flare up. You need to be seen by a neurologist who is familiar with PML or at least who will...
- 18 Replies
- 5071 Views
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Last post by centenarian100
Wed Oct 30, 2013 10:11 am
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PML Cases now reach 410!
by
HarryZ » Wed Oct 23, 2013 6:02 am
The number of known PML cases has now reached 410, an increase of 9 over the previous month. Don't know how many more deaths are involved in this...
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- 1810 Views
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Last post by HarryZ
Wed Oct 23, 2013 6:02 am
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Tysabri may be possible for more MS patients with new test
Replies: 1
by
MSUK » Tue Oct 08, 2013 2:55 am
First post
A blood test for L-selectin expression on circulating immune cells may identify multiple sclerosis patients who could safely receive natalizumab...
Last post
Wiendl reported relationships with Bayer Schering, Biogen Idec, Merck Serono, Novartis, Sanofi, Teva, and Novo Nordisk.
All the MS drug...
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- 1983 Views
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Last post by HarryZ
Thu Oct 10, 2013 10:11 am
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- 1499 Views
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Last post by MSUK
Wed Oct 09, 2013 1:52 am
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New Tysabri data from ECTRIMS
Replies: 1
by
MSUK » Thu Oct 03, 2013 1:15 am
First post
New Tysabri data show earlier treatment & longer-term use result in significant reductions in MS disease activity
Biogen Idec announced results from...
Last post
Well, I guess one can choose to believe what Biogen is telling us about Tysabri. Remember, this is the same company that once upon a time told us...
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- 1740 Views
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Last post by HarryZ
Thu Oct 03, 2013 11:04 am
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- 0 Replies
- 1506 Views
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Last post by wylerj
Fri Sep 27, 2013 6:03 am
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PML Cases now 372
Replies: 4
by
HarryZ » Sat Jun 22, 2013 6:58 pm
First post
The number of PML cases has risen another 13 during the past month, bringing the new total to 372. It isn't slowing down!
Harry
Last post
Guess we are up to 401 PML cases now!
- 4 Replies
- 2082 Views
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Last post by HarryZ
Wed Sep 25, 2013 6:57 am
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Biogen Idec, Elan facing suits over MS drug side effects
Replies: 7
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MSUK » Tue Sep 10, 2013 12:50 am
First post
Despite living with multiple sclerosis since 1997, Kimberley A. Yout kept a busy schedule, working full time as a money manager for a Boston bank and...
Last post
I was only DXed in March and my neuro tried to hawk Tysabri to me. My solution? Found a new neuro.
I refuse to use Ty until I have exhausted my...
- 7 Replies
- 2369 Views
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Last post by aredmosquito
Sun Sep 22, 2013 5:24 pm
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update on Tysabri--August 2013
Replies: 13
by
cheerleader » Thu May 23, 2013 8:32 am
First post
According to e-healthme, a reporting site which is based on reports by the FDA and self-reporting of actual patients, on May 22, 2013--
90,168 people...
Last post
With more than 115,000 patients globally treated with natalizumab for longer periods of time, that estimate is 1 per 330. In patients who test...
- 13 Replies
- 3884 Views
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Last post by HarryZ
Sun Aug 18, 2013 5:52 pm
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Tysabri rebound?
Replies: 3
by
Ernst » Sat Jul 20, 2013 6:32 am
First post
There is some research data about tysabri rebound effect.. but what causes it? Is there any scientific data about it?
Last post
There is some research data about tysabri rebound effect.. but what causes it? Is there any scientific data about it?
Here are some journal...
- 3 Replies
- 2153 Views
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Last post by NHE
Sat Jul 20, 2013 11:06 pm
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touch program
Replies: 1
by
jerrygallow » Fri Jul 19, 2013 7:01 pm
First post
anybody else think that the biggest problem with Tysabri, besides the fear of PML, is the annoying phone calls from the drug reps. If you don't...
Last post
anybody else think that the biggest problem with Tysabri, besides the fear of PML, is the annoying phone calls from the drug reps. If you don't...
- 1 Replies
- 1436 Views
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Last post by HarryZ
Sat Jul 20, 2013 9:28 am
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tysabri wash out period
Replies: 4
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onesickrace » Sun Oct 21, 2012 12:29 pm
First post
anyone spoken with their neuros about a wash out period before switching to another drug? im at 48-50 infusions and lookin to switch with biogens new...
Last post
I went off tysabri, against doctors orders in Aug 2012. I am now 13 infusions over due and one year off. I did have my first relapse in five years in...
- 4 Replies
- 3201 Views
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Last post by jerrygallow
Fri Jul 19, 2013 7:10 pm
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Early development of anti-natalizumab antibodies in MS
Replies: 1
by
MSUK » Wed Jun 19, 2013 11:30 pm
First post
Early development of anti-natalizumab antibodies in MS patients
Abstract
The purpose of this study is to monitor the development of...
Last post
Hmmm...almost 16% of Tysabri patients found with the drug's antibodies within the first couple of month's treatment and only now are they suggesting...
- 1 Replies
- 1527 Views
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Last post by HarryZ
Thu Jun 20, 2013 6:06 am
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Any Tysabri users want to change my mind?
Replies: 20
by
Jenmen0304 » Mon May 06, 2013 2:38 pm
First post
Just took my blood test to find out if I have the JC virus(hope I spelled right). If I am negative, the neurologist strongly recommends Tysabri. If I...
Last post
Haha Harry oh the sarcasm!! I am trying to be as positive as I can!!! Lol
- 20 Replies
- 4597 Views
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Last post by Jenmen0304
Sat May 18, 2013 5:40 am
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Now 359 cases of PML!
by
HarryZ » Fri May 17, 2013 3:54 am
Unfortunately the Tysabri related cases of PML have jumped 12 from last month bringing the new total to 359. Don't know if there has been any...
- 0 Replies
- 1568 Views
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Last post by HarryZ
Fri May 17, 2013 3:54 am
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Chickenpox
Replies: 2
by
Researcher » Wed Dec 05, 2012 7:24 am
First post
I am very interested in MS and hopefully they will eventually find a cure. My brother was diagnosed at the age of 28. He has a very aggressive and...
Last post
Have you ever had chickenpox?
Hi Researcher. I'm sorry to read about your brother and wish him well. Welcome to this site and feel free to make...
- 2 Replies
- 2392 Views
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Last post by euphoniaa
Fri May 03, 2013 1:47 am
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Natalizumab treatment reduces fatigue in multiple sclerosis
Replies: 1
by
MSUK » Thu Apr 11, 2013 1:04 am
First post
Fatigue is a significant symptom in multiple sclerosis (MS) patients. First-generation disease modifying therapies (DMTs) are at best moderately...
Last post
Can you imagine what the comments would be by the established MS world of medicine if someone outside of this group did a one-armed, non-controlled...
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- 1846 Views
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Last post by HarryZ
Thu Apr 11, 2013 7:57 am
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Biogen Idec gains commercial rights of Tysabri from Elan
Replies: 1
by
MSUK » Thu Apr 04, 2013 12:27 am
First post
Biogen Idec gains commercial rights of Tysabri from Elan Corporation
Biogen Idec has completed its purchase of Elan Corporation’s interest in...
Last post
Biogen Idec gains commercial rights of Tysabri from Elan Corporation
Biogen Idec has completed its purchase of Elan Corporation’s interest in...
- 1 Replies
- 1537 Views
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Last post by HarryZ
Thu Apr 04, 2013 4:37 am
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159 cases of PML with 29 deaths for Tysabri MS patients
Replies: 29
by
MSUK » Mon Oct 03, 2011 12:51 am
First post
According to information released by Biogen Idec, as of September 1, 2011 there have been 159 confirmed cases of progressive multifocal...
Last post
Bad news again:
As of March 5, 2013, there have been 343 confirmed cases of PML worldwide (121 in the US). 79 of 343 (23%) of the patients with PML...
- 29 Replies
- 10218 Views
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Last post by HarryZ
Fri Mar 22, 2013 5:27 am
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