MS Etiology and Pathogenesis

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Coronavirus (COVID-19): What You Need To Know

Last post by jimmylegs « Sat May 30, 2020 5:06 pm
Posted in General Discussion
Replies: 131
by jimmylegs » Sun Mar 15, 2020 4:10 am » in General Discussion
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First post

What You Need To Know About Coronavirus (COVID-19)

What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...

Last post

interesting potential links between COVID vulnerability, nutrition and MS:

New challenges from Covid-19 pandemic: an unexpected opportunity to...
131 Replies

11618 Views

Last post by jimmylegs
Sat May 30, 2020 5:06 pm

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Last post

T-cells dysregulation

Last post by frodo « Tue Jun 25, 2019 7:18 am

by frodo » Tue Jun 25, 2019 7:18 am

Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy...

0 Replies

441 Views

Last post by frodo
Tue Jun 25, 2019 7:18 am
Cortical lesions and GA

Last post by frodo « Wed Jun 19, 2019 4:26 am

by frodo » Wed Jun 19, 2019 4:26 am

This paper is about the effects of Glatimer Acetate in MS, but they include a very deep review about the status of the research:

Some excerpts:...

0 Replies

400 Views

Last post by frodo
Wed Jun 19, 2019 4:26 am
Age of cells populations in MS

Last post by frodo « Wed Jun 19, 2019 4:01 am

by frodo » Wed Jun 19, 2019 4:01 am

Using Carbon14 the researchers can calculate the age of different cells (oligodendrocytes are myelin producing cells and OPC are oligodendrocyte...

0 Replies

401 Views

Last post by frodo
Wed Jun 19, 2019 4:01 am
Early MS lesions: Astrocytes involved

Last post by frodo « Wed Jun 19, 2019 3:33 am

by frodo » Wed Jun 19, 2019 3:33 am

Multiple Sclerosis: Destruction and Regeneration of Astrocytes in Acute Lesions

Abstract

There are reports that astrocyte perivascular endfeet...

0 Replies

458 Views

Last post by frodo
Wed Jun 19, 2019 3:33 am
Real PPMS passed (again) to mice

Last post by frodo « Sun Jun 02, 2019 8:03 am

by frodo » Sun Jun 02, 2019 8:03 am

This has been done previously (see for example posts or but this new result confirms again the previous results.

Intrathecal Injections of PPMS...

0 Replies

593 Views

Last post by frodo
Sun Jun 02, 2019 8:03 am
Dawson fingers in anti-MOG disease

Last post by frodo « Sat Jun 01, 2019 9:19 am

by frodo » Sat Jun 01, 2019 9:19 am

Anti-MOG disease makes around 10% of diagnosed MS patients and until now was reported only in atypical MS. Dawson fingers was considered one of the...

0 Replies

433 Views

Last post by frodo
Sat Jun 01, 2019 9:19 am
Inside-out model: supporting papers.

Last post by ElliotB « Thu May 30, 2019 7:10 am
Replies: 5
by frodo » Wed Jan 30, 2019 2:28 am

First post

The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later...

Last post

All very interesting theories, thanks for posting them!

5 Replies

816 Views

Last post by ElliotB
Thu May 30, 2019 7:10 am
Personalized medicine: Prediction of natalizumab response

Last post by frodo « Tue May 28, 2019 6:29 am

by frodo » Tue May 28, 2019 6:29 am

Identification of CD4+ T cell biomarkers for predicting the response of patients with relapsing‑remitting multiple sclerosis to natalizumab...

0 Replies

542 Views

Last post by frodo
Tue May 28, 2019 6:29 am
Neurofilament light as biomarker

Last post by frodo « Tue May 28, 2019 6:26 am

by frodo » Tue May 28, 2019 6:26 am

Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case–control studies

Conclusions

CSF...

0 Replies

385 Views

Last post by frodo
Tue May 28, 2019 6:26 am
Review about proteomics for MS biomarkers

Last post by frodo « Tue May 28, 2019 6:24 am

by frodo » Tue May 28, 2019 6:24 am

Proteomic approaches to decipher mechanisms underlying pathogenesis in MS

Full PDF:

Conclusion

Proteomic analysis of CNS tissue and body...

0 Replies

393 Views

Last post by frodo
Tue May 28, 2019 6:24 am
T-cells from MS patients are toxic to mice neurons

Last post by frodo « Tue May 28, 2019 6:15 am

by frodo » Tue May 28, 2019 6:15 am

This report points to something toxic in MS T-cells

Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central...

0 Replies

443 Views

Last post by frodo
Tue May 28, 2019 6:15 am
MS metabolic profile for MS. Closer to a blood test.

Last post by frodo « Thu May 09, 2019 3:02 am
Replies: 1
by frodo » Thu May 09, 2019 1:22 am

First post

Metabolome-based signature of disease pathology in MS

Highlights

• Six serum metabolites were predictive for MS in males.
• Results support...

Last post

And here other report about another possible blood test. By the way, TWEAK is this:

Interestingly, related to angiogenesis too.

Here comes the...

1 Replies

400 Views

Last post by frodo
Thu May 09, 2019 3:02 am
Viruses: Hypoxia and viruses reactivation. CCSVI?

Last post by Kinora « Fri May 03, 2019 1:36 pm
Replies: 6
by frodo » Sun Mar 11, 2018 10:14 am

First post

Could be this the explanation of the relationship between CCSVI and MS?

This article points out that endogenous retroviruses that are normally...

Last post

I use a bio-health device for blood flow. It is configured to increase blood flow at the capillary level though an configured, multi-layered wave...

6 Replies

1338 Views

Last post by Kinora
Fri May 03, 2019 1:36 pm
RNA signature of different lesion types in MS

Last post by frodo « Tue Apr 30, 2019 4:34 am

by frodo » Tue Apr 30, 2019 4:34 am

Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Conclusions

Our study is not...

0 Replies

315 Views

Last post by frodo
Tue Apr 30, 2019 4:34 am
How EBV causes MS

Last post by frodo « Mon Apr 22, 2019 12:40 pm
Replies: 2
by frodo » Tue Apr 16, 2019 12:52 am

First post

In this review, the authors (Khan & Hassani) propose an integrated model of EBV involvement in MS pathology

Epstein-Barr Virus in Multiple...

Last post

It would be great to have a EBV vaccine to prevent new MS cases but that would not help to the already infected people.

It seems that...

2 Replies

383 Views

Last post by frodo
Mon Apr 22, 2019 12:40 pm
Up to 10% of MS cases are due to anti-Neurofascin autoantibody

Last post by frodo « Sun Apr 14, 2019 10:18 am

by frodo » Sun Apr 14, 2019 10:18 am

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before.

This...

0 Replies

335 Views

Last post by frodo
Sun Apr 14, 2019 10:18 am
Report against division of MS in clinical types

Last post by frodo « Wed Apr 03, 2019 6:56 am

by frodo » Wed Apr 03, 2019 6:56 am

It is interesting that this is finally getting contested, because it was introduced artificially by the pharma industry to get interferons approved....

0 Replies

417 Views

Last post by frodo
Wed Apr 03, 2019 6:56 am
phd thesis about exosomes and miRNA

Last post by NHE « Tue Apr 02, 2019 10:11 pm
Replies: 1
by frodo » Tue Apr 02, 2019 3:05 am

First post

A phd thesis freely avaliable about exosomes and miRNA, in case anybody is interested.

Last post

Thanks. Here's the abstract...

Exosomal MicroRNA Signatures in Central Nervous System Diseases
Saeideh Ebrahimkhani, University of Sydney, Sep 30,...

1 Replies

306 Views

Last post by NHE
Tue Apr 02, 2019 10:11 pm
Toxicity of B Cell Products in Multiple Sclerosis

Last post by frodo « Sun Mar 31, 2019 11:30 am

by frodo » Sun Mar 31, 2019 11:30 am

Again, a new report of B-cells from MS patients secreting something toxic:

Toxicity of Released B Cell Products in Multiple Sclerosis

Abstract:...

0 Replies

334 Views

Last post by frodo
Sun Mar 31, 2019 11:30 am
Nfl increases BEFORE damage appears on MRI

Last post by frodo « Thu Mar 28, 2019 5:51 am

by frodo » Thu Mar 28, 2019 5:51 am

It seems that Nfl (neurofilament light) are an not just a biomarker, but also related to the pathogenesis and measurable WEEKS BEFORE the damage has...

0 Replies

450 Views

Last post by frodo
Thu Mar 28, 2019 5:51 am
MS are several diseases. Description of an iron responsive type.

Last post by frodo « Tue Mar 26, 2019 5:18 am

by frodo » Tue Mar 26, 2019 5:18 am

Identification of an iron-responsive subtype in two children diagnosed with relapsing-remitting multiple sclerosis using whole exome sequencing

In...

0 Replies

652 Views

Last post by frodo
Tue Mar 26, 2019 5:18 am
several types of alterations in NAWM and NAGM

Last post by frodo « Sat Mar 23, 2019 4:25 am

by frodo » Sat Mar 23, 2019 4:25 am

Exploring metabolite profiling of patients with secondary progressive multiple sclerosis

Synopsis

Proton magnetic resonance spectroscopic...

0 Replies

244 Views

Last post by frodo
Sat Mar 23, 2019 4:25 am
Microglial activation and NAWM appear together

Last post by frodo « Wed Mar 20, 2019 8:20 am
Replies: 1
by frodo » Thu May 17, 2018 1:13 am

First post

Microglial activation and NAWM appear together. A study found that microglial activation (shown by PET imaging) and Normal appearing white matter...

Last post

This report points to three levels of damage in MS, being demyelination just the second stage.

Abstract

Quantifying white matter damage in...

1 Replies

779 Views

Last post by frodo
Wed Mar 20, 2019 8:20 am
B-cells from MS patients secrete something toxic, maybe exosomes.

Last post by frodo « Sat Mar 16, 2019 3:25 am

by frodo » Sat Mar 16, 2019 3:25 am

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

Most evidence from pathological studies suggests that...

0 Replies

395 Views

Last post by frodo
Sat Mar 16, 2019 3:25 am
Polineuropaties, CDIP and NF-155 in MS

Last post by frodo « Fri Mar 15, 2019 7:16 am
Replies: 1
by frodo » Fri Mar 15, 2019 7:15 am

1 Replies

210 Views

Last post by frodo
Fri Mar 15, 2019 7:16 am
ANA-positive MS and MRZ reaction

Last post by frodo « Mon Mar 11, 2019 9:05 am

by frodo » Mon Mar 11, 2019 9:05 am

Up to 60% of MS-patients present antinuclear autoantibodies (ANAs) in CSF and may be misdiagnosed. Regardless of the question about if ANA-positive...

0 Replies

389 Views

Last post by frodo
Mon Mar 11, 2019 9:05 am
The Interaction between Viral and Environmental Risk Factors

Last post by frodo « Mon Mar 11, 2019 3:03 am

by frodo » Mon Mar 11, 2019 3:03 am

The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is a...

0 Replies

315 Views

Last post by frodo
Mon Mar 11, 2019 3:03 am
Metabolomics profile of MS

Last post by frodo « Mon Mar 11, 2019 1:49 am
Replies: 1
by frodo » Mon Mar 11, 2019 1:24 am

First post

Several viral infections mimic MS. Before immune supresion or modulation is important to be sure that there is no infection in the CNS or things...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

1 Replies

255 Views

Last post by frodo
Mon Mar 11, 2019 1:49 am
Oligoclonal bands are responsive to medication

Last post by frodo « Sun Mar 10, 2019 11:30 am
Replies: 2
by frodo » Tue Jan 15, 2019 5:39 am

First post

Cladribine reduces oligoclonal bands (OCB) in MS, and MS gets better without them. These are the conclusions of a study ( which also points to a...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

2 Replies

517 Views

Last post by frodo
Sun Mar 10, 2019 11:30 am
MSRV (MS retro-virus) and EBV interaction

Last post by NHE « Tue Mar 05, 2019 12:49 am
Replies: 1
by frodo » Mon Mar 04, 2019 5:28 am

First post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Multiple sclerosis (MS) is a disease of...

Last post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Free full text.

1 Replies

394 Views

Last post by NHE
Tue Mar 05, 2019 12:49 am
HERV and MSRV viruses implicated. Temelimab works against them.

Last post by NHE « Sun Mar 03, 2019 3:20 pm
Replies: 2
by frodo » Sat Mar 02, 2019 3:54 am

First post

MSRV is a retrovirus consistently found in MS lesions.

When active, MSRV produces a protein called MSRV-envelope protein, or MSRV-Env, which...

Last post

What is the magnetization transfer ratio? Does it correspond to gristy56's idea that it is magnetite which damages the myelin sheath and that by...

2 Replies

605 Views

Last post by NHE
Sun Mar 03, 2019 3:20 pm
NATURE: Autoreplicating T-cells involved in MS

Last post by frodo « Wed Feb 27, 2019 3:09 am

by frodo » Wed Feb 27, 2019 3:09 am

Immune-cell crosstalk in multiple sclerosis

T cells from people with multiple sclerosis are more prone to divide in vitro than are T cells from...

0 Replies

254 Views

Last post by frodo
Wed Feb 27, 2019 3:09 am
NATURE: Specific T-cells induce grey matter degeneration

Last post by frodo « Wed Feb 27, 2019 2:34 am

by frodo » Wed Feb 27, 2019 2:34 am

An important article about T-cells has been published. There are some expert comments about it available at . They say that the progressive phase is...

0 Replies

404 Views

Last post by frodo
Wed Feb 27, 2019 2:34 am
new biomarker, in blood, and maybe able to classify patients

Last post by frodo « Thu Feb 21, 2019 6:47 pm

by frodo » Thu Feb 21, 2019 6:47 pm

Long non‐coding RNA AFAP1‐AS1 is upregulated in a subset of multiple sclerosis patients

Results

AFAP1‐AS1 was upregulated in male MS...

0 Replies

423 Views

Last post by frodo
Thu Feb 21, 2019 6:47 pm
Patterns thread: Selective treatment for the four patterns

Last post by frodo « Mon Feb 18, 2019 1:47 am
Replies: 14
by frodo » Sun Nov 26, 2017 4:04 am

First post

In this post I will try to keep track of the developments in the specific treatment of the four patterns, whose existence was at first disputed, but...

Last post

Mitochondrial defects in acute multiple sclerosis lesions.

Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of...

14 Replies

2703 Views

Last post by frodo
Mon Feb 18, 2019 1:47 am
Vascular problems in MS

Last post by vesta « Mon Feb 11, 2019 12:48 am
Replies: 5
by frodo » Fri Aug 17, 2018 1:28 am

First post

Maybe CCSVI theory is wrong, but there must be something related to the vascular system in MS. Two more reports about vascular problems associated to...

Last post

I meant WILL refer to. Vesta

5 Replies

1349 Views

Last post by vesta
Mon Feb 11, 2019 12:48 am
The picture of demyelinating diseases gets more complicated

Last post by frodo « Wed Feb 06, 2019 2:38 am

by frodo » Wed Feb 06, 2019 2:38 am

This is the current picture as far as the current knowledge suggest. The picture is more complex than previously thought, even if anti-neurofascin...

0 Replies

526 Views

Last post by frodo
Wed Feb 06, 2019 2:38 am
Immunoglobulin G analysis for diagnosis of MS

Last post by frodo « Tue Feb 05, 2019 11:49 pm

by frodo » Tue Feb 05, 2019 11:49 pm

High performance of cerebrospinal fluid immunoglobulin G analysis for diagnosis of multiple sclerosis

Background

The 2017 revision of the...

0 Replies

361 Views

Last post by frodo
Tue Feb 05, 2019 11:49 pm
Disordered immune system and lipid metabolism in MS

Last post by frodo « Tue Feb 05, 2019 2:38 am

by frodo » Tue Feb 05, 2019 2:38 am

A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients

Identification of autoimmune...

0 Replies

342 Views

Last post by frodo
Tue Feb 05, 2019 2:38 am
maybe B-cells are not so important

Last post by frodo « Sun Feb 03, 2019 9:43 am
Replies: 2
by frodo » Sun Feb 03, 2019 7:41 am

First post

The success of anti-CD20 monoclonal antibodies has put the focus on CD20 B-cells, but it could be that the mechanism of action is about depleting...

Last post

I would say that for reduction of disease activity they mean relapses, not progresion.

2 Replies

508 Views

Last post by frodo
Sun Feb 03, 2019 9:43 am
CSF can separate RRMS from PPMS

Last post by frodo « Sun Feb 03, 2019 7:49 am

by frodo » Sun Feb 03, 2019 7:49 am

Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing–Remitting Multiple Sclerosis

To better understand the...

0 Replies

728 Views

Last post by frodo
Sun Feb 03, 2019 7:49 am
Multi-shell diffusion MRI shows early WM changes

Last post by frodo « Sun Feb 03, 2019 1:46 am

by frodo » Sun Feb 03, 2019 1:46 am

It seems that multi-shell diffusion is some kind of new MRI protocol able to show the white matter early damage.

Evidence of early microstructural...

0 Replies

387 Views

Last post by frodo
Sun Feb 03, 2019 1:46 am
status of the research as of 2019

Last post by frodo « Wed Jan 30, 2019 1:07 am

by frodo » Wed Jan 30, 2019 1:07 am

There is a review here summarising the status of knowledge:

Excerpts:

- Evidence from MRI and pathological assessment (biopsies and autopsies)...

0 Replies

842 Views

Last post by frodo
Wed Jan 30, 2019 1:07 am
Multiple sclerosis in 2018: new therapies and biomarkers

Last post by frodo « Mon Jan 28, 2019 7:52 am

by frodo » Mon Jan 28, 2019 7:52 am

Multiple sclerosis in 2018: new therapies and biomarkers

From my point of view, there are two remarkable advances:

- Ibudilast, a...

0 Replies

317 Views

Last post by frodo
Mon Jan 28, 2019 7:52 am
2018 update: Incidence and prevalence rates of Multiple Sclerosis in Canada

Last post by frodo « Mon Jan 28, 2019 6:12 am
Replies: 2
by jimmylegs » Sun Jan 27, 2019 7:38 am

First post

PHAC releases incidence and prevalence rates of Multiple Sclerosis in Canada (2018)

Background:

The Canadian Chronic Disease Surveillance System...

Last post

Just a remark. Prevalence rate increase could be due to a longer life and could be a good thing. Incidence rate increase is the big problem, but they...

2 Replies

619 Views

Last post by frodo
Mon Jan 28, 2019 6:12 am
Pre-active lesions hold clues to stop MS

Last post by frodo « Wed Jan 23, 2019 6:25 am

by frodo » Wed Jan 23, 2019 6:25 am

Preactive lesions in multiple sclerosis

Compelling evidence is accumulating for pathological changes in normal-appearing white matter of MS...

0 Replies

321 Views

Last post by frodo
Wed Jan 23, 2019 6:25 am
Biomarker for response to interferon

Last post by frodo « Tue Jan 22, 2019 4:28 am

by frodo » Tue Jan 22, 2019 4:28 am

Semaphorin 4A as a biomarker of multiple sclerosis and neuromyelitis optica spectrum disorder

Abstract

Selecting appropriate treatment from...

0 Replies

578 Views

Last post by frodo
Tue Jan 22, 2019 4:28 am
Wolfson Institute of Preventive Medicine. EBV is MS cause.

Last post by Kheuer « Wed Jan 09, 2019 8:50 am
Replies: 1
by frodo » Sun Dec 23, 2018 5:51 am

First post

There is strong evidence that Epstein Barr Virus (EBV) infection is a cause of Multiple Sclerosis. Immunisation against
EBV could in future prevent...

Last post

EBV and the Human Herpes Virus family activate the epigenetic pathway for the MS genetically prone.

The EBV does not cause MS.

An inflammatory...

1 Replies

748 Views

Last post by Kheuer
Wed Jan 09, 2019 8:50 am
miR-223 in MS: Strong biomarker and probably pathogenic

Last post by frodo « Wed Jan 09, 2019 8:23 am
Replies: 2
by frodo » Fri Dec 21, 2018 6:05 am

First post

The miR-223: An Inflammatory MicroRNA Involved in Pathogenesis of Multiple Sclerosis

Full text link:

Abstract:

Multiple sclerosis (MS) is the...

Last post

Interesting. Both articles say more or less the opposite. For the first authors miR-223 is bad and for the others is good, but anyway they agree in...

2 Replies

971 Views

Last post by frodo
Wed Jan 09, 2019 8:23 am
Targeting progression in MS (PPMS+SPMS)

Last post by frodo « Tue Jan 08, 2019 1:09 am

by frodo » Tue Jan 08, 2019 1:09 am

Source:

In 2018, the distinguishing pathological features of white matter lesions in patients with progressive multiple sclerosis (MS) were...

0 Replies

777 Views

Last post by frodo
Tue Jan 08, 2019 1:09 am

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