MS Etiology and Pathogenesis

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Biomarkers: CIS to MS conversion

Last post by frodo « Mon Jun 11, 2018 11:14 pm

by frodo » Mon Jun 11, 2018 11:14 pm

Identification of candidate biomarkers in converting and non-converting clinically isolated syndrome by proteomics analysis of cerebrospinal fluid...

0 Replies

739 Views

Last post by frodo
Mon Jun 11, 2018 11:14 pm
Metabolics altered in RRMS

Last post by frodo « Mon Jun 11, 2018 11:10 pm

by frodo » Mon Jun 11, 2018 11:10 pm

These people report four metabolic pathways altered in RRMS: glycerophospholipid, citrate cycle, sphingolipids, and pyruvate metabolism....

0 Replies

654 Views

Last post by frodo
Mon Jun 11, 2018 11:10 pm
MRI diagnosing protocol updated (MS consortium)

Last post by frodo « Mon Jun 11, 2018 10:44 pm

by frodo » Mon Jun 11, 2018 10:44 pm

The consortium of multiple sclerosis centers has published an updated protocol as of 2018. As far as I can see, now they recommend advanced MRI...

0 Replies

719 Views

Last post by frodo
Mon Jun 11, 2018 10:44 pm
oligoclonal bands type M predict response to interferon & GA

Last post by frodo « Mon Jun 11, 2018 10:32 pm

by frodo » Mon Jun 11, 2018 10:32 pm

Different clinical response to interferon beta and glatiramer acetate related to the presence of oligoclonal IgM bands in CSF in multiple sclerosis...

0 Replies

608 Views

Last post by frodo
Mon Jun 11, 2018 10:32 pm
MS also affects the peripheral nervous system

Last post by NHE « Wed Jun 06, 2018 3:05 am
Replies: 1
by frodo » Tue Jun 05, 2018 7:09 am

First post

This is a report from a German team using some kind of MRI named magnetic resonance neurography :

Neurographic MRI Reveals Peripheral Nerve...

Last post

Here's the article's abstract from PubMed.

Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography....

1 Replies

761 Views

Last post by NHE
Wed Jun 06, 2018 3:05 am
PPMS: Biomarker able to discern from RRMS

Last post by frodo « Wed Jun 06, 2018 2:45 am

by frodo » Wed Jun 06, 2018 2:45 am

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing‐remitting MS

Abstract

Multiple sclerosis (MS) is an...

0 Replies

690 Views

Last post by frodo
Wed Jun 06, 2018 2:45 am
Biomarkers and diagnostic tests pipeline

Last post by frodo « Tue Jun 05, 2018 4:31 am

by frodo » Tue Jun 05, 2018 4:31 am

Diagnosis in MS is based in clinical finding. Usually all tests require to prove that there are lesions in the brain disseminated in time and space....

0 Replies

660 Views

Last post by frodo
Tue Jun 05, 2018 4:31 am
Vitamin D: Dysequilibrium in MS

Last post by frodo « Sun Jun 03, 2018 11:20 pm
Replies: 2
by frodo » Sun Jun 03, 2018 9:39 am

First post

Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study

Background

Parathyroid glands...

Last post

would have been nice if they bothered to give any detail on the form of magnesium used. also, i'd have loved to see what happened to vit D...

2 Replies

763 Views

Last post by frodo
Sun Jun 03, 2018 11:20 pm
Imaging biomarkers. Chemical composition by MRS as biomarker

Last post by frodo « Sun Jun 03, 2018 9:34 am

by frodo » Sun Jun 03, 2018 9:34 am

MRS (Magnetic Resonance Spectroscopy) can show the chemical composition of the brain. It seems that some chemical markers (the relationship of...

0 Replies

620 Views

Last post by frodo
Sun Jun 03, 2018 9:34 am
MRZ Reaction as biomarker without oligoclonal bands

Last post by frodo « Sun Jun 03, 2018 9:29 am

by frodo » Sun Jun 03, 2018 9:29 am

MS without oligoclonal bands is difficult to diagnosize. The MRZ reaction can help.

The intrathecal polyspecific antiviral immune response (Mrz...

0 Replies

640 Views

Last post by frodo
Sun Jun 03, 2018 9:29 am
personalized medicine for MS

Last post by frodo « Thu May 31, 2018 7:52 am

by frodo » Thu May 31, 2018 7:52 am

Towards personalized therapy for multiple sclerosis: prediction of individual treatment response

Abstract

Timely initiation of effective therapy...

0 Replies

631 Views

Last post by frodo
Thu May 31, 2018 7:52 am
choose your favorite explanation

Last post by frodo « Tue May 29, 2018 12:28 am

by frodo » Tue May 29, 2018 12:28 am

This is about the secondary progressive phase enigmas.

Anti-inflammatory drugs that reduce inflammatory (immune) attacks in patients with RRMS fail...

0 Replies

588 Views

Last post by frodo
Tue May 29, 2018 12:28 am
Finally a biomarker

Last post by frodo « Tue May 22, 2018 6:46 am
Replies: 2
by frodo » Sun May 20, 2018 11:15 am

First post

It seems that they have found finally a biomarker for MS. Previously light chains (pieces of immunoglobulins in blood) had been reported that could...

Last post

I believe that the term 'light chains' is referring to protein. Immunoglobulins are antibodies. They are composed of two heavy chains and two light...

2 Replies

719 Views

Last post by frodo
Tue May 22, 2018 6:46 am
Sera from MS patients disrupt the BBB

Last post by frodo « Thu May 17, 2018 9:46 pm

by frodo » Thu May 17, 2018 9:46 pm

0 Replies

648 Views

Last post by frodo
Thu May 17, 2018 9:46 pm
DNA-binding factor TOX might trigger MS

Last post by crunkz « Thu May 17, 2018 11:31 am

by crunkz » Thu May 17, 2018 11:31 am

Researchers at the University of Geneva (UNIGE), Switzerland, and Geneva University Hospitals (HUG) have identified a DNA-binding factor called TOX...

0 Replies

610 Views

Last post by crunkz
Thu May 17, 2018 11:31 am
Inside-out model: Axonal damage mechanisms in early MS

Last post by frodo « Thu May 17, 2018 1:55 am

by frodo » Thu May 17, 2018 1:55 am

Early axonal damage in normal appearing white matter in multiple sclerosis: Novel insights from multi-shell diffusion MRI

Abstract :...

0 Replies

613 Views

Last post by frodo
Thu May 17, 2018 1:55 am
Activated FoxO3 blocks myelin production

Last post by crunkz « Thu May 10, 2018 4:53 pm

by crunkz » Thu May 10, 2018 4:53 pm

Links:

Results showed that one specific-size fragment of Hialuronic Acid affected OPCs. Treating rat cells modeling white matter disease with...

0 Replies

660 Views

Last post by crunkz
Thu May 10, 2018 4:53 pm
Inside-out model: Altered myelin could trigger immune attack

Last post by frodo « Tue May 08, 2018 5:16 am

by frodo » Tue May 08, 2018 5:16 am

Biochemically altered myelin triggers autoimmune demyelination

Abstract

Although immune attack against central nervous system (CNS) myelin is a...

0 Replies

638 Views

Last post by frodo
Tue May 08, 2018 5:16 am
Diagnosis: Diffusion Tensor Imaging shows NAWM

Last post by frodo « Tue May 08, 2018 4:52 am

by frodo » Tue May 08, 2018 4:52 am

Role of MRI Diffusion Tensor Imaging in Assessment of Normal Appearing White Matter in Cases of Multiple Sclerosis.

Abstract:

Background:...

0 Replies

579 Views

Last post by frodo
Tue May 08, 2018 4:52 am
Biomarkers: Excesive yawning associated to MS

Last post by frodo « Tue May 08, 2018 4:49 am

by frodo » Tue May 08, 2018 4:49 am

Yawning and cortisol levels in multiple sclerosis: potential new diagnostic tool

Abstract

Yawning is a significant behavioural response and,...

0 Replies

561 Views

Last post by frodo
Tue May 08, 2018 4:49 am
Biomarkers: Biomarker to separate RRMS and progresive forms

Last post by frodo « Mon Apr 30, 2018 4:26 am

by frodo » Mon Apr 30, 2018 4:26 am

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing‐remitting MS

Abstract

Multiple sclerosis (MS) is...

0 Replies

692 Views

Last post by frodo
Mon Apr 30, 2018 4:26 am
NAWM is the beginning of MS and can be seen with special MRI

Last post by frodo « Sun Apr 29, 2018 11:19 pm

by frodo » Sun Apr 29, 2018 11:19 pm

DTI (Diffusion Tensor Imaging MRI) shows the most early tissue injury in MS, when atrophy and lesions are not yet detectable (non lesional damage,...

0 Replies

598 Views

Last post by frodo
Sun Apr 29, 2018 11:19 pm
Biomarkers: Remains of a retrovirus in blood as biomarker

Last post by frodo « Tue Apr 24, 2018 11:27 pm

by frodo » Tue Apr 24, 2018 11:27 pm

Clinical profile of a new serum biomarker as a potential product of endogenous human retroviral protein degradation in patients with multiple...

0 Replies

639 Views

Last post by frodo
Tue Apr 24, 2018 11:27 pm
Biomarkers: Distinction between RRMS and PMS

Last post by frodo « Tue Apr 24, 2018 11:24 pm

by frodo » Tue Apr 24, 2018 11:24 pm

They do not say wether they refer to primary-progressive or SPMS

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from...

0 Replies

608 Views

Last post by frodo
Tue Apr 24, 2018 11:24 pm
Pathogenic distinction between PP and SPMS still debated

Last post by frodo « Mon Apr 23, 2018 5:18 am

by frodo » Mon Apr 23, 2018 5:18 am

It seems that PPMS and SPMS courses are different.

Demyelination and Neurodegeneration along the Visual Pathway are more prominent in Secondary...

0 Replies

610 Views

Last post by frodo
Mon Apr 23, 2018 5:18 am
Biomarkers. MS signature found in CSF

Last post by frodo « Thu Apr 19, 2018 10:04 pm

by frodo » Thu Apr 19, 2018 10:04 pm

Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

Abstract...

0 Replies

665 Views

Last post by frodo
Thu Apr 19, 2018 10:04 pm
Biomarkers. Response to Fingolimod can be predicted.

Last post by frodo « Thu Apr 19, 2018 12:31 pm

by frodo » Thu Apr 19, 2018 12:31 pm

Predicting therapeutic response to fingolimod treatment in multiple sclerosis patients

Summary

Fingolimod, an orally active immunomodulatory...

0 Replies

607 Views

Last post by frodo
Thu Apr 19, 2018 12:31 pm
PPMS: Two different subtypes set appart by fluid biomarkers

Last post by frodo « Wed Apr 18, 2018 9:51 am

by frodo » Wed Apr 18, 2018 9:51 am

Transcriptional profiling of Primary Progressive Multiple Sclerosis patients identifies Fast and Slow progression patterns (P1.321)

Abstract...

0 Replies

617 Views

Last post by frodo
Wed Apr 18, 2018 9:51 am
CCSVI: Angioplasty could work in a subgroup of patients

Last post by frodo « Wed Apr 11, 2018 6:45 am

by frodo » Wed Apr 11, 2018 6:45 am

Chronic Cerebro-Spinal Venous Insufficiency in Multiple Sclerosis: Is It the End?

It was published the long awaited Italian clinical trial...

0 Replies

694 Views

Last post by frodo
Wed Apr 11, 2018 6:45 am
Progressive MS: Review of medications

Last post by frodo « Wed Apr 11, 2018 6:40 am

by frodo » Wed Apr 11, 2018 6:40 am

Interesting this article. They acklowledge that It remains a challenge to identify outcome measures that accurately reflect the underlying pathology...

0 Replies

662 Views

Last post by frodo
Wed Apr 11, 2018 6:40 am
Type II pattern impressively responsive to alemtuzumab

Last post by frodo « Tue Apr 03, 2018 4:51 am

by frodo » Tue Apr 03, 2018 4:51 am

They openly speak about a B-cell driven multiple sclerosis for the first time, and they identify it to the pattern II.

Rescue therapy with...

0 Replies

789 Views

Last post by frodo
Tue Apr 03, 2018 4:51 am
EBV: Leukocytes could be unable to control EBV infection.

Last post by frodo « Mon Apr 02, 2018 1:03 am

by frodo » Mon Apr 02, 2018 1:03 am

Human leukocytes have some proteins named Human Leukocyte antigens (HLA) alleles . They are associated with disease susceptibility,

HLA alleles...

0 Replies

718 Views

Last post by frodo
Mon Apr 02, 2018 1:03 am
EBV. Less antibodies than expected

Last post by frodo « Wed Mar 28, 2018 8:56 am

by frodo » Wed Mar 28, 2018 8:56 am

Low intrathecal antibody production despite high seroprevalence of Epstein–Barr virus in multiple sclerosis: a review of the literature

0 Replies

759 Views

Last post by frodo
Wed Mar 28, 2018 8:56 am
Biomarkers. Gadolinium predicts response to medication

Last post by frodo « Mon Mar 26, 2018 12:33 pm

by frodo » Mon Mar 26, 2018 12:33 pm

Gadolinium predicts response to rituxan

0 Replies

741 Views

Last post by frodo
Mon Mar 26, 2018 12:33 pm
Biomarkers: Plasma citrulline level

Last post by Scott1 « Mon Mar 26, 2018 4:47 am
Replies: 1
by frodo » Mon Mar 26, 2018 1:36 am

First post

Plasma citrulline levels are increased in patients with multiple sclerosis.

Abstract

BACKGROUND:

Multiple sclerosis is an inflammatory...

Last post

Hi,

They might have jumped to the wrong conclusion. If Citrulline appears over expressed then Argininosuccinate synthase could just be...

1 Replies

698 Views

Last post by Scott1
Mon Mar 26, 2018 4:47 am
EBV: now infected b-cells can be detected

Last post by frodo « Sun Mar 25, 2018 4:31 am

by frodo » Sun Mar 25, 2018 4:31 am

Now EBV infected b cells can be detected

Defining latent EBV load in B lymphocytes: Application to multiple sclerosis

Abstract

Multiple...

0 Replies

710 Views

Last post by frodo
Sun Mar 25, 2018 4:31 am
Iron in the brain by a new MRI technique (QSM)

Last post by frodo « Fri Mar 23, 2018 8:44 am

by frodo » Fri Mar 23, 2018 8:44 am

Significance and In Vivo Detection of Iron-Laden Microglia in White Matter Multiple Sclerosis Lesions

This article debunks a lot of myths. Some...

0 Replies

708 Views

Last post by frodo
Fri Mar 23, 2018 8:44 am
NAWM damage correlates to disability

Last post by frodo « Fri Mar 23, 2018 8:16 am

by frodo » Fri Mar 23, 2018 8:16 am

Maybe lesions are not so important as we have always supposed.

Despite they are invisible to normal MRI, it seems that damage in the Normal...

0 Replies

748 Views

Last post by frodo
Fri Mar 23, 2018 8:16 am
Herpes viruses in the CNS including EBV. What do we know.

Last post by frodo « Thu Mar 22, 2018 12:17 am

by frodo » Thu Mar 22, 2018 12:17 am

This review is centered in herpes simplex virus 1 and human herpesvirus 6, but they deal with all the family, including EBV. Recently it was found...

0 Replies

719 Views

Last post by frodo
Thu Mar 22, 2018 12:17 am
Biomarkers for disease course.

Last post by frodo « Wed Mar 21, 2018 12:33 am

by frodo » Wed Mar 21, 2018 12:33 am

A specific micro-RNA can predict the disease course. Interestingly, they also found a connection (again) to EBV infection.

Common genetic variation...

0 Replies

757 Views

Last post by frodo
Wed Mar 21, 2018 12:33 am
DTI images show hidden damage in the brain

Last post by frodo « Tue Mar 20, 2018 10:30 am

by frodo » Tue Mar 20, 2018 10:30 am

DTI images (Difusion Tensor MRI) show more damage that what is usually recognized, even during remissions:

Brain microstructural injury occurs in...

0 Replies

692 Views

Last post by frodo
Tue Mar 20, 2018 10:30 am
Viruses: Hypoxia and viruses reactivation. CCSVI?

Last post by frodo « Tue Mar 20, 2018 9:56 am
Replies: 5
by frodo » Sun Mar 11, 2018 10:14 am

First post

Could be this the explanation of the relationship between CCSVI and MS?

This article points out that endogenous retroviruses that are normally...

Last post

Before we get too excited about Endogenous Retroviruses (ERVs), allow me to point out that the Epstein Barr Virus (EBV) – cause of Mononucleosis...

5 Replies

893 Views

Last post by frodo
Tue Mar 20, 2018 9:56 am
Copper levels altered in MS: As biomarker and pathogen agent

Last post by frodo « Mon Mar 12, 2018 11:34 pm

by frodo » Mon Mar 12, 2018 11:34 pm

Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects

Abstract

Although many studies have been...

0 Replies

718 Views

Last post by frodo
Mon Mar 12, 2018 11:34 pm
biomarkers guided therapy and cytokines

Last post by frodo « Mon Mar 12, 2018 11:28 pm

by frodo » Mon Mar 12, 2018 11:28 pm

This review summarises what is known about tayloring MS treatment based in biomarkers.

Abstract:

The concept and recognized components of...

0 Replies

658 Views

Last post by frodo
Mon Mar 12, 2018 11:28 pm
Patterns: Plasmapheresis confirmed as selective treatment.

Last post by frodo « Wed Feb 28, 2018 4:34 am

by frodo » Wed Feb 28, 2018 4:34 am

Plasmapheresis has been confirmed a second time as a selective treatment for patterns I and II. This has been consistently reported since 2005....

0 Replies

836 Views

Last post by frodo
Wed Feb 28, 2018 4:34 am
Metabolic changes found in MS white matter

Last post by frodo « Wed Feb 28, 2018 4:18 am

by frodo » Wed Feb 28, 2018 4:18 am

Could MS be a metabolic disease?

Lipid biochemical changes detected in normal appearing white matter of chronic multiple sclerosis by spectral...

0 Replies

685 Views

Last post by frodo
Wed Feb 28, 2018 4:18 am
Heterogeneity: New Ways of “Seeing” the mechanistic MS

Last post by vesta « Fri Feb 23, 2018 10:48 am
Replies: 3
by frodo » Wed Feb 21, 2018 9:54 am

First post

New Ways of “Seeing” the Mechanistic Heterogeneity of Multiple Sclerosis Plaque Pathogenesis

Background: Over the past few decades, we have...

Last post

Translation: It looks like we need to take Prof Zamboni's CCSVI theory seriously.

Regards, Vesta

Yes vesta. I would say that some cases could be...

3 Replies

846 Views

Last post by vesta
Fri Feb 23, 2018 10:48 am
Biomarkers: LOTUS in CSF

Last post by frodo « Fri Feb 23, 2018 2:14 am

by frodo » Fri Feb 23, 2018 2:14 am

LOTUS (lateral olfactory tract usher substance) could be used as biomarker for inflammation:

Cerebrospinal fluid level of Nogo receptor 1 antagonist...

0 Replies

775 Views

Last post by frodo
Fri Feb 23, 2018 2:14 am
HERVs reactivation linked to demyelination

Last post by frodo « Sat Feb 17, 2018 7:36 am

by frodo » Sat Feb 17, 2018 7:36 am

HERVs (human endogenous retroviruses) are linked to the initiating microglial inflammation

Up-to-date knowledge about the association between...

0 Replies

729 Views

Last post by frodo
Sat Feb 17, 2018 7:36 am
Patterns: Different symptoms. Plasmapheresis.

Last post by frodo « Sat Feb 10, 2018 9:33 am

by frodo » Sat Feb 10, 2018 9:33 am

Forgetting around 1% of MS people with a pattern IV, all the cases belong to a given pattern. Apheresis (pasmapheresis) could make the difference....

0 Replies

809 Views

Last post by frodo
Sat Feb 10, 2018 9:33 am

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