A forum to discuss research on the origins of MS and its development.
-
-
- 0 Replies
- 583 Views
-
Last post by frodo
Sun Apr 29, 2018 11:19 pm
-
-
- 0 Replies
- 619 Views
-
Last post by frodo
Tue Apr 24, 2018 11:27 pm
-
-
- 0 Replies
- 598 Views
-
Last post by frodo
Tue Apr 24, 2018 11:24 pm
-
-
- 0 Replies
- 597 Views
-
Last post by frodo
Mon Apr 23, 2018 5:18 am
-
-
Biomarkers. MS signature found in CSF
by
frodo » Thu Apr 19, 2018 10:04 pm
Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients
Abstract...
- 0 Replies
- 647 Views
-
Last post by frodo
Thu Apr 19, 2018 10:04 pm
-
-
- 0 Replies
- 589 Views
-
Last post by frodo
Thu Apr 19, 2018 12:31 pm
-
-
- 0 Replies
- 605 Views
-
Last post by frodo
Wed Apr 18, 2018 9:51 am
-
-
- 0 Replies
- 682 Views
-
Last post by frodo
Wed Apr 11, 2018 6:45 am
-
-
Progressive MS: Review of medications
by
frodo » Wed Apr 11, 2018 6:40 am
Interesting this article. They acklowledge that It remains a challenge to identify outcome measures that accurately reflect the underlying pathology...
- 0 Replies
- 627 Views
-
Last post by frodo
Wed Apr 11, 2018 6:40 am
-
-
- 0 Replies
- 763 Views
-
Last post by frodo
Tue Apr 03, 2018 4:51 am
-
-
- 0 Replies
- 699 Views
-
Last post by frodo
Mon Apr 02, 2018 1:03 am
-
-
EBV. Less antibodies than expected
by
frodo » Wed Mar 28, 2018 8:56 am
Low intrathecal antibody production despite high seroprevalence of Epstein–Barr virus in multiple sclerosis: a review of the literature
- 0 Replies
- 748 Views
-
Last post by frodo
Wed Mar 28, 2018 8:56 am
-
-
- 0 Replies
- 722 Views
-
Last post by frodo
Mon Mar 26, 2018 12:33 pm
-
-
Biomarkers: Plasma citrulline level
Replies: 1
by
frodo » Mon Mar 26, 2018 1:36 am
First post
Plasma citrulline levels are increased in patients with multiple sclerosis.
Abstract
BACKGROUND:
Multiple sclerosis is an inflammatory...
Last post
Hi,
They might have jumped to the wrong conclusion. If Citrulline appears over expressed then Argininosuccinate synthase could just be...
- 1 Replies
- 675 Views
-
Last post by Scott1
Mon Mar 26, 2018 4:47 am
-
-
- 0 Replies
- 691 Views
-
Last post by frodo
Sun Mar 25, 2018 4:31 am
-
-
- 0 Replies
- 696 Views
-
Last post by frodo
Fri Mar 23, 2018 8:44 am
-
-
NAWM damage correlates to disability
by
frodo » Fri Mar 23, 2018 8:16 am
Maybe lesions are not so important as we have always supposed.
Despite they are invisible to normal MRI, it seems that damage in the Normal...
- 0 Replies
- 711 Views
-
Last post by frodo
Fri Mar 23, 2018 8:16 am
-
-
- 0 Replies
- 702 Views
-
Last post by frodo
Thu Mar 22, 2018 12:17 am
-
-
- 0 Replies
- 742 Views
-
Last post by frodo
Wed Mar 21, 2018 12:33 am
-
-
- 0 Replies
- 665 Views
-
Last post by frodo
Tue Mar 20, 2018 10:30 am
-
-
Viruses: Hypoxia and viruses reactivation. CCSVI?
Replies: 5
by
frodo » Sun Mar 11, 2018 10:14 am
First post
Could be this the explanation of the relationship between CCSVI and MS?
This article points out that endogenous retroviruses that are normally...
Last post
Before we get too excited about Endogenous Retroviruses (ERVs), allow me to point out that the Epstein Barr Virus (EBV) – cause of Mononucleosis...
- 5 Replies
- 854 Views
-
Last post by frodo
Tue Mar 20, 2018 9:56 am
-
-
- 0 Replies
- 705 Views
-
Last post by frodo
Mon Mar 12, 2018 11:34 pm
-
-
- 0 Replies
- 649 Views
-
Last post by frodo
Mon Mar 12, 2018 11:28 pm
-
-
- 0 Replies
- 812 Views
-
Last post by frodo
Wed Feb 28, 2018 4:34 am
-
-
- 0 Replies
- 674 Views
-
Last post by frodo
Wed Feb 28, 2018 4:18 am
-
-
Heterogeneity: New Ways of “Seeing” the mechanistic MS
Replies: 3
by
frodo » Wed Feb 21, 2018 9:54 am
First post
New Ways of “Seeing” the Mechanistic Heterogeneity of Multiple Sclerosis Plaque Pathogenesis
Background: Over the past few decades, we have...
Last post
Translation: It looks like we need to take Prof Zamboni's CCSVI theory seriously.
Regards, Vesta
Yes vesta. I would say that some cases could be...
- 3 Replies
- 821 Views
-
Last post by vesta
Fri Feb 23, 2018 10:48 am
-
-
Biomarkers: LOTUS in CSF
by
frodo » Fri Feb 23, 2018 2:14 am
LOTUS (lateral olfactory tract usher substance) could be used as biomarker for inflammation:
Cerebrospinal fluid level of Nogo receptor 1 antagonist...
- 0 Replies
- 751 Views
-
Last post by frodo
Fri Feb 23, 2018 2:14 am
-
-
- 0 Replies
- 717 Views
-
Last post by frodo
Sat Feb 17, 2018 7:36 am
-
-
- 0 Replies
- 794 Views
-
Last post by frodo
Sat Feb 10, 2018 9:33 am
-
-
EBV virus: Astrocytes and microglia (and B-cells) infected.
Replies: 1
by
frodo » Mon Feb 05, 2018 9:57 am
First post
Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.
Abstract
Multiple...
Last post
And related to the problem with Microglia:
Significance and in vivo detection of iron-laden microglia in white matter multiple sclerosis lesions...
- 1 Replies
- 745 Views
-
Last post by frodo
Mon Feb 05, 2018 1:48 pm
-
-
There is damage after the lesion
by
frodo » Mon Feb 05, 2018 9:46 am
Maybe it is something that we knew, but now there is proof. After the MS lesion appears, the tissue damage continues.
Evidence of progressive tissue...
- 0 Replies
- 721 Views
-
Last post by frodo
Mon Feb 05, 2018 9:46 am
-
-
- 0 Replies
- 663 Views
-
Last post by frodo
Mon Feb 05, 2018 9:28 am
-
-
- 0 Replies
- 806 Views
-
Last post by frodo
Wed Jan 31, 2018 8:45 am
-
-
review from Hans Lassman
Replies: 2
by
frodo » Wed Jan 24, 2018 11:00 am
First post
Hans Lassman is one of the leaders in MS research. He does not say the word autoimmune anymore, nor speaks too much about myelin.
Multiple Sclerosis...
Last post
soluble factors like in venous blood for example???
I would say that they have in mind something neurotoxic in the CNS ... We will have to wait for...
- 2 Replies
- 833 Views
-
Last post by frodo
Wed Jan 31, 2018 8:42 am
-
-
Study suggests remarkable approach to MS treatment
Replies: 6
by
MSUK » Mon Feb 08, 2016 8:02 am
First post
A group of researchers at the Stanford Department of Neurology and Neurological Sciences exploring the use of a synthetic bile acid agonist in a...
Last post
Do you have any links to research that has shown that the mice with the MS model induced using this technique, respond to treatments more akin to...
- 6 Replies
- 1692 Views
-
Last post by frodo
Wed Jan 24, 2018 10:12 am
-
-
Osteopontin
by
frodo » Mon Jan 22, 2018 5:12 am
Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis.
Abstract
Identifying a reliable...
- 0 Replies
- 685 Views
-
Last post by frodo
Mon Jan 22, 2018 5:12 am
-
-
Finally Mystery Solved: Researchers Find The Cause of MS
Replies: 7
by
seeva » Wed Jan 17, 2018 10:36 pm
First post
DEAR FRIENDS GOOD NEWS PLEASE READ
regards
seeva
Last post
Where Rab32 is present, the team discovered that a part of the cell that stores calcium (endoplasmic reticulum or ER) gets too close to the...
- 7 Replies
- 1000 Views
-
Last post by NHE
Sun Jan 21, 2018 8:48 am
-
-
- 0 Replies
- 790 Views
-
Last post by frodo
Thu Jan 11, 2018 9:34 am
-
-
- 2 Replies
- 837 Views
-
Last post by frodo
Tue Jan 09, 2018 11:14 am
-
-
- 0 Replies
- 649 Views
-
Last post by frodo
Tue Jan 09, 2018 10:55 am
-
-
- 0 Replies
- 641 Views
-
Last post by frodo
Tue Jan 09, 2018 6:05 am
-
-
- 0 Replies
- 856 Views
-
Last post by frodo
Sat Dec 30, 2017 4:25 am
-
-
- 0 Replies
- 730 Views
-
Last post by frodo
Sat Dec 30, 2017 4:16 am
-
-
2017 study: Pathogenic implications of Fe & Zn in MS lesions
Replies: 5
by
jimmylegs » Thu Dec 07, 2017 6:08 am
First post
Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions (2017)
Abstract
Multiple sclerosis (MS) is a chronic...
Last post
gonna take a while to get my head around this stuff
Nutritional immunity beyond iron: a role for manganese and zinc (2010)
...The struggle for...
- 5 Replies
- 1004 Views
-
Last post by jimmylegs
Sun Dec 24, 2017 9:34 am
-
-
Plasma exchange in MS
by
frodo » Sun Dec 17, 2017 11:53 am
Plasma exchange in severe acute relapses of multiple sclerosis - Results from a Portuguese cohort.
Abstract
BACKGROUND:
Relapses in Multiple...
- 0 Replies
- 840 Views
-
Last post by frodo
Sun Dec 17, 2017 11:53 am
-
-
- 0 Replies
- 745 Views
-
Last post by frodo
Sun Dec 17, 2017 11:48 am
-
-
- 0 Replies
- 750 Views
-
Last post by frodo
Thu Dec 14, 2017 12:59 am
-
-
biomarkers for disease activity
Replies: 2
by
frodo » Sun Oct 08, 2017 4:34 am
First post
Fluid biomarkers for disease activity in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory and degenerative central nervous system...
Last post
Two more biomarkers. This time for microglial activation and axonal injury. This article is a review but it refers to the original research articles,...
- 2 Replies
- 1001 Views
-
Last post by frodo
Mon Dec 11, 2017 1:18 am
-
-
Are microglia the ultimate culprit?
Replies: 2
by
frodo » Wed Dec 06, 2017 11:15 am
First post
MS lesions develop in the so-called normal appearing areas (NAWM). Pre-active lesions start developing before the blood-brain barrier (BBB) breakdown...
Last post
multifactorial thing, ms, imho. can't be nailed down to one smoking gun.
Are we really sure that it is multifactorial? We really do not know too...
- 2 Replies
- 767 Views
-
Last post by frodo
Mon Dec 11, 2017 1:14 am
-
-
lack of a micro-RNA as a biomarker
by
frodo » Sat Dec 09, 2017 3:59 am
MicroRNAs are proposed as a biomarker of MS. When myelin is broken, some fragments of RNA appear in blood.
But a recent research has appeared...
- 0 Replies
- 735 Views
-
Last post by frodo
Sat Dec 09, 2017 3:59 am
Forum permissions
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
