MS Etiology and Pathogenesis

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EBV again. Genetic evidence of its involvement

Last post by frodo « Fri Aug 17, 2018 1:44 am

by frodo » Fri Aug 17, 2018 1:44 am

Genetic evidence that the latency III stage of Epstein-Barr Virus infection is a therapeutic target for Multiple Sclerosis

Abstract

Genome wide...

0 Replies

593 Views

Last post by frodo
Fri Aug 17, 2018 1:44 am
Biomarkers: proteomic profiling of human saliva

Last post by frodo « Wed Aug 08, 2018 2:57 pm

by frodo » Wed Aug 08, 2018 2:57 pm

Top-down proteomic profiling of human saliva in multiple sclerosis patients.

Abstract

Multiple sclerosis is a chronic disease of the central...

0 Replies

674 Views

Last post by frodo
Wed Aug 08, 2018 2:57 pm
review about neurofilaments

Last post by frodo « Tue Aug 07, 2018 3:10 pm

by frodo » Tue Aug 07, 2018 3:10 pm

Editorial of the Multiple Sclerosis Journal

Are neurofilaments valuable biomarkers for long-term disease prognostication in MS?

Neuroaxonal...

0 Replies

641 Views

Last post by frodo
Tue Aug 07, 2018 3:10 pm
DNA methiylation signatures in MS twins

Last post by frodo « Tue Aug 07, 2018 6:57 am

by frodo » Tue Aug 07, 2018 6:57 am

DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis

Abstract

Multiple sclerosis (MS) is...

0 Replies

633 Views

Last post by frodo
Tue Aug 07, 2018 6:57 am
Neurofilaments in CSF predict behaviour of MS in ten years

Last post by frodo « Tue Aug 07, 2018 6:53 am

by frodo » Tue Aug 07, 2018 6:53 am

This could save some people with mild MS from being treated

Neurofilaments and 10-year follow-up in multiple sclerosis

Background:

The role...

0 Replies

625 Views

Last post by frodo
Tue Aug 07, 2018 6:53 am
Microglia is just another sympthom, not the cause

Last post by frodo « Sun Jul 29, 2018 10:47 pm

by frodo » Sun Jul 29, 2018 10:47 pm

It seems that microglia activation could be a symptom of axonal damage, and not the ultimate cause nor related to pre-active lesions. Microglia...

0 Replies

705 Views

Last post by frodo
Sun Jul 29, 2018 10:47 pm
Can we tame microglia?

Last post by frodo « Sat Jul 28, 2018 10:53 am

by frodo » Sat Jul 28, 2018 10:53 am

It seems so.

Microglia P2X4 receptors as pharmacological targets for demyelinating diseases

Multiple sclerosis (MS) is a chronic inflammatory...

0 Replies

681 Views

Last post by frodo
Sat Jul 28, 2018 10:53 am
Epstein Barr virus again

Last post by frodo « Sat Jul 28, 2018 9:07 am
Replies: 1
by frodo » Mon Jan 22, 2018 3:17 am

First post

Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple...

Last post

This article also points out a connection between the four patterns theory and the EBV brain infection.

It is also known that the CNS immune...

1 Replies

1127 Views

Last post by frodo
Sat Jul 28, 2018 9:07 am
IgM+ patients should not be treated with interferon

Last post by frodo « Thu Jul 26, 2018 11:14 pm

by frodo » Thu Jul 26, 2018 11:14 pm

MS patients present oligoclonal bands (OCB) in their cerebrospinal fluid (CSF). Among the oligoclonal bands there could be some related to...

0 Replies

699 Views

Last post by frodo
Thu Jul 26, 2018 11:14 pm
Dysregulated EBV infection in MS. Old but relevant.

Last post by jimmylegs « Wed Jul 25, 2018 6:46 am
Replies: 2
by frodo » Sun Jul 22, 2018 6:18 pm

First post

They know since 2007 that EBV is to blame. What are they waiting for to try antiviral therapies??

Dysregulated Epstein-Barr virus infection in the...

Last post

my 2c: correlation vs causation. i have limited but lab documented evidence of reducing both EBV viral load and food sensitivities (n=1, but not me)...

2 Replies

701 Views

Last post by jimmylegs
Wed Jul 25, 2018 6:46 am
review of PET in several diseases, including MS

Last post by frodo « Mon Jul 23, 2018 10:59 am

by frodo » Mon Jul 23, 2018 10:59 am

Drugs evaluated in these studies include specific therapeutics which have already granted FDA licensure like interferon beta, glatiramer acetate, and...

0 Replies

678 Views

Last post by frodo
Mon Jul 23, 2018 10:59 am
Lesions evolution under PET

Last post by frodo « Mon Jul 23, 2018 10:50 am

by frodo » Mon Jul 23, 2018 10:50 am

PET (Positron imaging technology) is a imaging method able to show the molecular structure of a lesion.

Several radioligands, compounds that work as...

0 Replies

674 Views

Last post by frodo
Mon Jul 23, 2018 10:50 am
OCB negative MS - immunogenetically distinct

Last post by frodo « Sun Jul 22, 2018 6:22 pm

by frodo » Sun Jul 22, 2018 6:22 pm

Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct

Abstract

We sought to determine...

0 Replies

701 Views

Last post by frodo
Sun Jul 22, 2018 6:22 pm
Biomarkers: Response to Glatiramer Acetate predictable

Last post by frodo « Sun Jul 22, 2018 10:26 am

by frodo » Sun Jul 22, 2018 10:26 am

It seems that a biomarker in blood predicts response to GA

Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with...

0 Replies

671 Views

Last post by frodo
Sun Jul 22, 2018 10:26 am
Personalized medicine: Selective therapy

Last post by frodo « Tue Jul 10, 2018 2:06 am

by frodo » Tue Jul 10, 2018 2:06 am

Here there is a freely available review about the state-of-the-art as it was 2 years ago.

Personalised medicine for multiple sclerosis care...

0 Replies

739 Views

Last post by frodo
Tue Jul 10, 2018 2:06 am
Personalized medicine in multiple sclerosis

Last post by frodo « Thu Jul 05, 2018 1:12 am

by frodo » Thu Jul 05, 2018 1:12 am

Personalized medicine here means to divide the patients in subgroups so that the response to medication is optimal.

It seems that some hospitals...

0 Replies

832 Views

Last post by frodo
Thu Jul 05, 2018 1:12 am
Progressive MS: Natural evolution in PPMS and SPMS

Last post by frodo « Wed Jul 04, 2018 4:21 am

by frodo » Wed Jul 04, 2018 4:21 am

Pathology and Pathogenesis of Progressive Multiple Sclerosis: Concepts and Controversies

Summary

Multiple sclerosis changes not only its...

0 Replies

820 Views

Last post by frodo
Wed Jul 04, 2018 4:21 am
Heterogeneity: CSF profile predicts response to interferons

Last post by frodo « Wed Jul 04, 2018 3:58 am

by frodo » Wed Jul 04, 2018 3:58 am

In a small study patients were clustered into 6 distinct subsets by baseline cytokine profiles of CSF.

Two subsets were associated with patients...

0 Replies

712 Views

Last post by frodo
Wed Jul 04, 2018 3:58 am
Barts blog: EBV in Brain

Last post by frodo « Tue Jul 03, 2018 2:29 am

by frodo » Tue Jul 03, 2018 2:29 am

EBV in Brain

Source:

The best evidence to date does suggest that EBV is present in both MS and control brains, but is more common in pwMS (90% vs...

0 Replies

769 Views

Last post by frodo
Tue Jul 03, 2018 2:29 am
Immunoglobulins and B-cells

Last post by frodo « Mon Jul 02, 2018 2:13 am

by frodo » Mon Jul 02, 2018 2:13 am

It seems that B-cells are responsible for producing the oligoclonal Bands (OCB) that appear in MS. For some reason which I don't understand, the...

0 Replies

762 Views

Last post by frodo
Mon Jul 02, 2018 2:13 am
Evolution of the lesions during three years

Last post by ElliotB « Tue Jun 26, 2018 4:47 am
Replies: 1
by frodo » Mon Jun 25, 2018 11:48 pm

First post

This is a french study about how lesions evolve seeing by MRI. The article is in PDF and freely available.

Abstract : Obtaining information on...

Last post

This time lapse video spans a 12 month time frame of someone with RRMS. It is quite fascinating!
It is interesting that they (lesions) can grow,...

1 Replies

902 Views

Last post by ElliotB
Tue Jun 26, 2018 4:47 am
How B-cells produce MS

Last post by frodo « Tue Jun 26, 2018 3:10 am

by frodo » Tue Jun 26, 2018 3:10 am

For most of the authors is not an issue anymore if B-cells are the cause of MS. The question is how they produce MS. Here there is a fully available...

0 Replies

869 Views

Last post by frodo
Tue Jun 26, 2018 3:10 am
MS B-cells in vitro do weird things and CCSVI connection.

Last post by frodo « Tue Jun 26, 2018 12:31 am

by frodo » Tue Jun 26, 2018 12:31 am

This is an article that I am reading slowly, as I do not understand most of the things it says. But the summary is that MS B-cells do weird things....

0 Replies

812 Views

Last post by frodo
Tue Jun 26, 2018 12:31 am
OCB-negative MS

Last post by frodo « Tue Jun 19, 2018 5:49 am
Replies: 5
by frodo » Tue Jun 19, 2018 5:22 am

First post

OCB (oligoclonal bands) negative MS is rare, around 10% in patients of european ancestry, but higher outside this population. Notice that Pattern III...

Last post

A study of oligoclonal band negative multiple sclerosis.

Abstract

OBJECTIVES --To determine whether oligoclonal band (OCB) negative multiple...

5 Replies

1122 Views

Last post by frodo
Tue Jun 19, 2018 5:49 am
Demyelinating disorders. Cousins of MS updated.

Last post by frodo « Tue Jun 19, 2018 5:05 am
Replies: 1
by frodo » Tue Jun 19, 2018 5:03 am

First post

An interesting diagram speaking about Anti-MOG associated encephalomyelitis. Some MS cases could be anti-MOG in reality. Get informed.

Clinical...

Last post

Update: Intermediate cases between MS and NMO

B cell depleting therapy for multiple sclerosis overlapping with neuromyelitis optica spectrum...

1 Replies

849 Views

Last post by frodo
Tue Jun 19, 2018 5:05 am
MS as a neuro-degenerative disorder

Last post by frodo « Tue Jun 19, 2018 4:53 am

by frodo » Tue Jun 19, 2018 4:53 am

Development of biomarkers for multiple sclerosis as a neurodegenerative disorder

Abstract

Multiple sclerosis (MS) is the most common...

0 Replies

746 Views

Last post by frodo
Tue Jun 19, 2018 4:53 am
MRZ Reaction: Helps to distinguish MS from its mimics

Last post by frodo « Tue Jun 19, 2018 1:01 am

by frodo » Tue Jun 19, 2018 1:01 am

The mrz reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis

Abstract

Background...

0 Replies

740 Views

Last post by frodo
Tue Jun 19, 2018 1:01 am
simvastatin mechanism is independent from cholesterol

Last post by frodo « Mon Jun 18, 2018 4:33 am

by frodo » Mon Jun 18, 2018 4:33 am

Whatever simvastatin does in MS is independent from its cholesterol function

Abstract

The analysis of clinical trials is limited to...

0 Replies

656 Views

Last post by frodo
Mon Jun 18, 2018 4:33 am
Biomarkers: CIS to MS conversion

Last post by frodo « Mon Jun 11, 2018 11:14 pm

by frodo » Mon Jun 11, 2018 11:14 pm

Identification of candidate biomarkers in converting and non-converting clinically isolated syndrome by proteomics analysis of cerebrospinal fluid...

0 Replies

774 Views

Last post by frodo
Mon Jun 11, 2018 11:14 pm
Metabolics altered in RRMS

Last post by frodo « Mon Jun 11, 2018 11:10 pm

by frodo » Mon Jun 11, 2018 11:10 pm

These people report four metabolic pathways altered in RRMS: glycerophospholipid, citrate cycle, sphingolipids, and pyruvate metabolism....

0 Replies

679 Views

Last post by frodo
Mon Jun 11, 2018 11:10 pm
MRI diagnosing protocol updated (MS consortium)

Last post by frodo « Mon Jun 11, 2018 10:44 pm

by frodo » Mon Jun 11, 2018 10:44 pm

The consortium of multiple sclerosis centers has published an updated protocol as of 2018. As far as I can see, now they recommend advanced MRI...

0 Replies

811 Views

Last post by frodo
Mon Jun 11, 2018 10:44 pm
oligoclonal bands type M predict response to interferon & GA

Last post by frodo « Mon Jun 11, 2018 10:32 pm

by frodo » Mon Jun 11, 2018 10:32 pm

Different clinical response to interferon beta and glatiramer acetate related to the presence of oligoclonal IgM bands in CSF in multiple sclerosis...

0 Replies

637 Views

Last post by frodo
Mon Jun 11, 2018 10:32 pm
MS also affects the peripheral nervous system

Last post by NHE « Wed Jun 06, 2018 3:05 am
Replies: 1
by frodo » Tue Jun 05, 2018 7:09 am

First post

This is a report from a German team using some kind of MRI named magnetic resonance neurography :

Neurographic MRI Reveals Peripheral Nerve...

Last post

Here's the article's abstract from PubMed.

Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography....

1 Replies

801 Views

Last post by NHE
Wed Jun 06, 2018 3:05 am
PPMS: Biomarker able to discern from RRMS

Last post by frodo « Wed Jun 06, 2018 2:45 am

by frodo » Wed Jun 06, 2018 2:45 am

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing‐remitting MS

Abstract

Multiple sclerosis (MS) is an...

0 Replies

742 Views

Last post by frodo
Wed Jun 06, 2018 2:45 am
Biomarkers and diagnostic tests pipeline

Last post by frodo « Tue Jun 05, 2018 4:31 am

by frodo » Tue Jun 05, 2018 4:31 am

Diagnosis in MS is based in clinical finding. Usually all tests require to prove that there are lesions in the brain disseminated in time and space....

0 Replies

708 Views

Last post by frodo
Tue Jun 05, 2018 4:31 am
Vitamin D: Dysequilibrium in MS

Last post by frodo « Sun Jun 03, 2018 11:20 pm
Replies: 2
by frodo » Sun Jun 03, 2018 9:39 am

First post

Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study

Background

Parathyroid glands...

Last post

would have been nice if they bothered to give any detail on the form of magnesium used. also, i'd have loved to see what happened to vit D...

2 Replies

796 Views

Last post by frodo
Sun Jun 03, 2018 11:20 pm
Imaging biomarkers. Chemical composition by MRS as biomarker

Last post by frodo « Sun Jun 03, 2018 9:34 am

by frodo » Sun Jun 03, 2018 9:34 am

MRS (Magnetic Resonance Spectroscopy) can show the chemical composition of the brain. It seems that some chemical markers (the relationship of...

0 Replies

645 Views

Last post by frodo
Sun Jun 03, 2018 9:34 am
MRZ Reaction as biomarker without oligoclonal bands

Last post by frodo « Sun Jun 03, 2018 9:29 am

by frodo » Sun Jun 03, 2018 9:29 am

MS without oligoclonal bands is difficult to diagnosize. The MRZ reaction can help.

The intrathecal polyspecific antiviral immune response (Mrz...

0 Replies

668 Views

Last post by frodo
Sun Jun 03, 2018 9:29 am
personalized medicine for MS

Last post by frodo « Thu May 31, 2018 7:52 am

by frodo » Thu May 31, 2018 7:52 am

Towards personalized therapy for multiple sclerosis: prediction of individual treatment response

Abstract

Timely initiation of effective therapy...

0 Replies

657 Views

Last post by frodo
Thu May 31, 2018 7:52 am
choose your favorite explanation

Last post by frodo « Tue May 29, 2018 12:28 am

by frodo » Tue May 29, 2018 12:28 am

This is about the secondary progressive phase enigmas.

Anti-inflammatory drugs that reduce inflammatory (immune) attacks in patients with RRMS fail...

0 Replies

628 Views

Last post by frodo
Tue May 29, 2018 12:28 am
Finally a biomarker

Last post by frodo « Tue May 22, 2018 6:46 am
Replies: 2
by frodo » Sun May 20, 2018 11:15 am

First post

It seems that they have found finally a biomarker for MS. Previously light chains (pieces of immunoglobulins in blood) had been reported that could...

Last post

I believe that the term 'light chains' is referring to protein. Immunoglobulins are antibodies. They are composed of two heavy chains and two light...

2 Replies

750 Views

Last post by frodo
Tue May 22, 2018 6:46 am
Sera from MS patients disrupt the BBB

Last post by frodo « Thu May 17, 2018 9:46 pm

by frodo » Thu May 17, 2018 9:46 pm

0 Replies

680 Views

Last post by frodo
Thu May 17, 2018 9:46 pm
DNA-binding factor TOX might trigger MS

Last post by crunkz « Thu May 17, 2018 11:31 am

by crunkz » Thu May 17, 2018 11:31 am

Researchers at the University of Geneva (UNIGE), Switzerland, and Geneva University Hospitals (HUG) have identified a DNA-binding factor called TOX...

0 Replies

639 Views

Last post by crunkz
Thu May 17, 2018 11:31 am
Inside-out model: Axonal damage mechanisms in early MS

Last post by frodo « Thu May 17, 2018 1:55 am

by frodo » Thu May 17, 2018 1:55 am

Early axonal damage in normal appearing white matter in multiple sclerosis: Novel insights from multi-shell diffusion MRI

Abstract :...

0 Replies

667 Views

Last post by frodo
Thu May 17, 2018 1:55 am
Activated FoxO3 blocks myelin production

Last post by crunkz « Thu May 10, 2018 4:53 pm

by crunkz » Thu May 10, 2018 4:53 pm

Links:

Results showed that one specific-size fragment of Hialuronic Acid affected OPCs. Treating rat cells modeling white matter disease with...

0 Replies

673 Views

Last post by crunkz
Thu May 10, 2018 4:53 pm
Inside-out model: Altered myelin could trigger immune attack

Last post by frodo « Tue May 08, 2018 5:16 am

by frodo » Tue May 08, 2018 5:16 am

Biochemically altered myelin triggers autoimmune demyelination

Abstract

Although immune attack against central nervous system (CNS) myelin is a...

0 Replies

676 Views

Last post by frodo
Tue May 08, 2018 5:16 am
Diagnosis: Diffusion Tensor Imaging shows NAWM

Last post by frodo « Tue May 08, 2018 4:52 am

by frodo » Tue May 08, 2018 4:52 am

Role of MRI Diffusion Tensor Imaging in Assessment of Normal Appearing White Matter in Cases of Multiple Sclerosis.

Abstract:

Background:...

0 Replies

613 Views

Last post by frodo
Tue May 08, 2018 4:52 am
Biomarkers: Excesive yawning associated to MS

Last post by frodo « Tue May 08, 2018 4:49 am

by frodo » Tue May 08, 2018 4:49 am

Yawning and cortisol levels in multiple sclerosis: potential new diagnostic tool

Abstract

Yawning is a significant behavioural response and,...

0 Replies

603 Views

Last post by frodo
Tue May 08, 2018 4:49 am
Biomarkers: Biomarker to separate RRMS and progresive forms

Last post by frodo « Mon Apr 30, 2018 4:26 am

by frodo » Mon Apr 30, 2018 4:26 am

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing‐remitting MS

Abstract

Multiple sclerosis (MS) is...

0 Replies

728 Views

Last post by frodo
Mon Apr 30, 2018 4:26 am
NAWM is the beginning of MS and can be seen with special MRI

Last post by frodo « Sun Apr 29, 2018 11:19 pm

by frodo » Sun Apr 29, 2018 11:19 pm

DTI (Diffusion Tensor Imaging MRI) shows the most early tissue injury in MS, when atrophy and lesions are not yet detectable (non lesional damage,...

0 Replies

621 Views

Last post by frodo
Sun Apr 29, 2018 11:19 pm

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