PM10

[Petr75]

2025 Dec 31
Linking Particulate Matter Exposure and Neurological Disorders: Evidence from Epidemiology, Biomarkers and Mechanistic Studies
https://pubmed.ncbi.nlm.nih.gov/41482167/

Abstract

Exposure to particulate matter (PM) including fine (PM₂.₅), coarse (PM₁₀), and ultrafine particles (UFPM) has emerged as a critical environmental determinant of neurological disorders, including Alzheimer's and Parkinson's diseases, neurodevelopmental impairments, and cognitive decline. This review integrates evidence from 129 research articles (2002-2025) to elucidate the mechanistic, biomarker-based, and public health dimensions of PM-induced neurotoxicity. Mechanistic pathways include oxidative stress, neuroinflammation, mitochondrial dysfunction, and blood-brain barrier disruption, with documented structural and functional damage in brain regions ...