Insulin--Could This Be the Key?

[lyndacarol]

First Lyon posted this link in October:

http://www.nationalmssociety.org/Brochu ... yofMS1.asp

It mentioned that almost 80 years ago scientists found most damage around the blood vessels in MS.

Now from msnews.bostoncure.org I read a posting on January 3, 2007, by skedlo, which stated:

Below is a link to an abstract linking immune response to worsening of atherosclerosis. This might not seem like it would be important compared to MS. But, in Dr. Le Gacs papers, listed on the site, he goes into specific detail about vascular events causing lesions in the capillaries (implicating BBB breakdown initially) being the first observed events in the pathogenesis of MS -- not demyelination, which comes later. This may have serious implications to further understanding how MS begins, and ways to stop, minimize damage or a faster track to diagnosis of MS. http://www.nature.com/modpathol/journal ... 0791a.html

The common implication of blood vessels or vascular system intrigues me--of course, you know I think excess circulating insulin is causing initial damage and then the immune system steps in.

More food for thought.

[Lyon]

Hi Lynda,
Thanks for the reading material!
Bob

[lyndacarol]

My, Lyon, you are fast! In the short time I took to look for the Legac papers referred to in skedlo's posting you are here!!!

I am interested in finding the actual abstracts or articles reporting his "specific detail about vascular events causing lesions in the capillaries...being the first observed events in the pathogenesis of MS...."

I have searched at the nature site, tried google--no luck. I would like to find it directly, can anyone help me? I believe his name is Paul LeGac, M.D. in France.

[Lyon]

I have searched at the nature site, tried google--no luck. I would like to find it directly, can anyone help me? I believe his name is Eric Legac, M.D. in France.

So far the best results seem to be shown by typing "Legac vascular" into the search engines. But like me, you are probably going to bump into sites which want money for the information. I'm too cheap to spend money before I know for sure that it's the paper I want.

My wife's trying to talk me into a movie tonight so I'm not going to have time to do an exhaustive search but my interest is up. I got the idea from one of the initial summaries I viewed that Legac seemed to be saying that parasites seem to mediate this effect. It was just a quick peek, I'm probably jumping the gun.

If you've got the time, do as I do, become a stalker. Find out where he works, get his email address and write and ask him to send you the paper. It's worked every time so far.

Bob

[jimmylegs]

plus the correspondence contact is from UBC which is sooo cooool! i love vancouver. you should go visit him personally LC

[Lyon]

Gosh jimmy, there have been claims in the past that you are a stalker but I gave you the benefit of the doubt........at this point I have to wonder how you instantly knew this guy's GPS coordinants and brand of cologne he wears?
Bob

[jimmylegs]

well best friends i guess! hahaha whatever!
legs

[Lyon]

That's good. You know I'm kidding you.
Bob

[jimmylegs]

just to clear up the mystery, when you read the abstract posted above

http://www.nature.com/modpathol/journal ... 0791a.html

it says this:

Mod Pathol 2003;16(5):460–470

Granzyme B in Atherosclerosis and Transplant Vascular Disease: Association with Cell Death and Atherosclerotic Disease Severity
Jonathan C Choy B.Sc.1, Paul C McDonald Ph.D.1, Agripina C Suarez B.Sc.1, Vivian H Y Hung1, Janet E Wilson B.Sc., M.T.1, Bruce M McManus M.D., Ph.D.1 and David J Granville Ph.D.1

1The iCAPTUR4E Centre/UBC McDonald Research Laboratories, Department of Pathology and Laboratory Medicine, St. Paul's Hospital/Providence Health Care–University of British Columbia, Vancouver, British Columbia, Canada

Correspondence: David J. Granville, Ph.D., The iCAPTUR4E Centre/UBC McDonald Research Laboratories, Room 292, Burrard Building, St. Paul's Hospital, Vancouver, British Columbia, V6Z 1Y6 Canada. fax: (604) 806-8351; e-mail: dgranville@mrl.ubc.ca

Accepted 13 February 2003.

[lyndacarol]

Since this item mentioned insulin, I am posting this here.

I admit I watch entirely too much TV--today I watched the local NBC news at midday (as I do every day!). The health segment concerned infertility. I'm sorry I did not catch the details such as doctor's name or location, but I know you folks can research it if you're interested.

The report said scientists are noting a connection between weight and infertility, that women, who cannot conceive, do conceive after losing some weight. (They were not talking about obese women either!) One sentence that did stick with me was that women with Polycystic Ovarian Syndrome have too much insulin to become pregnant.

Insulin may not be the root of all medical problems, but it is involved in more than just diabetes, I'm sure--even MS, I'll bet.

[CureOrBust]

I recently had an Fasting insulin test. I have been in contact with lindacarol and there is some controversy over the test protocol. In australia, the blood does not need to be frozen. I had the blood drawn on a friday after noon, so it wasnt tested until monay or possibly even later. Now, lindacarol spoke with her dr's office, and they say their protocol requires the blood to be frozen. So, there is this possible bone of contention.

In australia, the results for "normal" are quoted between 0 and 20. My test came back with a result of <2. Below 2, the lab either cannot differentiate the result, or dont bother to do so. So, if this test was performed correctly, it would appear MY insulin leves were what would be expected for fasting. I did probably fast more than required as I had an early dinner the day before.

[sh8un]

Hi LC,
Not sure if you are keeping a track of ppl's insulin levels but I just read COB's post and thought I should tell you about mine. I have had a fasting insulin done several times and it's always been normal.
NN

[jimmylegs]

yep i think it'll be one of those things that is a factor for some and not for others.

one day, just saying "MS" will be like saying "cancer" now. what kind of cancer? and just the other day i was told about a televised panel of cancer experts were saying how different even breast cancer and its treatment can be, from one patient to the next, so even "breast cancer" is therefore an umbrella term for a number of conditions.

one day i'll have to see about my own fasting insulin. i've had a great time dealing with psoriasis, since i was about twelve, which is associated with increased risk of lymphoma and diabetes, and yep it's associated with MS and the rheumatoid arthritis suffered by my mom's mom and the various cancers suffered by my other three grandparents (kidney, breast, leukemia). yay.

also there are links between candida overgrowth (which has been my shadow pest since diaper days), insulin, and psoriasis. i figure the day my psoriasis and candida problem goes away will be the day i have finally figured out what the heck is going awry in there and i might even save myself from the big C. or any other of the big A-list.

[CureOrBust]

This is a new drug that has some effects on Insulin Sensitivity. But it also appears to have a reverse effect where in it would increase insulin also. It is seen as a replacement or adjunct to daily shots by those with type II diabeties.

http://www.dia-btech.com.au/about_us/bu ... ities.html

In summary, ISF-402 peptide is non-toxic and works in two ways to lower blood glucose:

* by making the body more sensitive to insulin by activating glycogen synthase, the enzyme that coverts blood sugar to glycogen, and
* by delaying the breakdown of insulin itself thereby prolonging its blood sugar lowering effects.

I saw the story on a current affairs program, and they talked as if it was just about to be released.


PS: "ISF" stands for Insulin Sensitivity Factor

[lyndacarol]

I have been puzzled by your insulin test protocol and results since you had it conducted, CureOrBust. I just can't explain any of it!

I contacted a nurse at my physician's office. She confirmed that the specimen must be frozen; but she urged me as well to contact the lab where testing is done.

I contacted the OSF St. Francis Hospital lab in Peoria, IL; I was told the same and even requested a copy of the page concerned with the test.

Insulin
Collection Information
1.0 (0.5) mL
Serum
Frozen
Be careful to avoid hemolysis.
Schedule: Monday-Friday
Reference Range: 6 - 27 uU/mL

Performing Lab: OSF System Laboratory
TAT: 1-3 days
Methods: Chemiluminescent

I will still pursue national standardization, perhaps CLIA or another government agency has some. Everyone I have talked with so far thinks freezing is important to avoid degradation of the sample. Can you medical professionals out there help me find a source for an answer to this question?

In the meantime, I still urge folks with extant MS symptoms to ask for this test. It costs about $50 if your insurance will not cover it (mine did). A desirable, "normal" outcome should be below 10 (Mine was 12.).