A forum to discuss research on the origins of MS and its development.
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Last post by frodo
Tue Apr 24, 2018 11:27 pm
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Last post by frodo
Tue Apr 24, 2018 11:24 pm
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Last post by frodo
Mon Apr 23, 2018 5:18 am
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Biomarkers. MS signature found in CSF
by
frodo » Thu Apr 19, 2018 10:04 pm
Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients
Abstract...
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Last post by frodo
Thu Apr 19, 2018 10:04 pm
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Last post by frodo
Thu Apr 19, 2018 12:31 pm
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Last post by frodo
Wed Apr 18, 2018 9:51 am
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Last post by frodo
Wed Apr 11, 2018 6:45 am
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Progressive MS: Review of medications
by
frodo » Wed Apr 11, 2018 6:40 am
Interesting this article. They acklowledge that It remains a challenge to identify outcome measures that accurately reflect the underlying pathology...
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Last post by frodo
Wed Apr 11, 2018 6:40 am
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Last post by frodo
Tue Apr 03, 2018 4:51 am
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Last post by frodo
Mon Apr 02, 2018 1:03 am
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EBV. Less antibodies than expected
by
frodo » Wed Mar 28, 2018 8:56 am
Low intrathecal antibody production despite high seroprevalence of Epstein–Barr virus in multiple sclerosis: a review of the literature
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Last post by frodo
Wed Mar 28, 2018 8:56 am
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Last post by frodo
Mon Mar 26, 2018 12:33 pm
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Biomarkers: Plasma citrulline level
Replies: 1
by
frodo » Mon Mar 26, 2018 1:36 am
First post
Plasma citrulline levels are increased in patients with multiple sclerosis.
Abstract
BACKGROUND:
Multiple sclerosis is an inflammatory...
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Hi,
They might have jumped to the wrong conclusion. If Citrulline appears over expressed then Argininosuccinate synthase could just be...
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Last post by Scott1
Mon Mar 26, 2018 4:47 am
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Last post by frodo
Sun Mar 25, 2018 4:31 am
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Last post by frodo
Fri Mar 23, 2018 8:44 am
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NAWM damage correlates to disability
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frodo » Fri Mar 23, 2018 8:16 am
Maybe lesions are not so important as we have always supposed.
Despite they are invisible to normal MRI, it seems that damage in the Normal...
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Last post by frodo
Fri Mar 23, 2018 8:16 am
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Last post by frodo
Thu Mar 22, 2018 12:17 am
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Biomarkers for disease course.
by
frodo » Wed Mar 21, 2018 12:33 am
A specific micro-RNA can predict the disease course. Interestingly, they also found a connection (again) to EBV infection.
Common genetic variation...
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Last post by frodo
Wed Mar 21, 2018 12:33 am
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Last post by frodo
Tue Mar 20, 2018 10:30 am
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Last post by frodo
Mon Mar 12, 2018 11:34 pm
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Last post by frodo
Mon Mar 12, 2018 11:28 pm
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Last post by frodo
Wed Feb 28, 2018 4:34 am
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Last post by frodo
Wed Feb 28, 2018 4:18 am
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Heterogeneity: New Ways of “Seeing” the mechanistic MS
Replies: 3
by
frodo » Wed Feb 21, 2018 9:54 am
First post
New Ways of “Seeing” the Mechanistic Heterogeneity of Multiple Sclerosis Plaque Pathogenesis
Background: Over the past few decades, we have...
Last post
Translation: It looks like we need to take Prof Zamboni's CCSVI theory seriously.
Regards, Vesta
Yes vesta. I would say that some cases could be...
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Last post by vesta
Fri Feb 23, 2018 10:48 am
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Biomarkers: LOTUS in CSF
by
frodo » Fri Feb 23, 2018 2:14 am
LOTUS (lateral olfactory tract usher substance) could be used as biomarker for inflammation:
Cerebrospinal fluid level of Nogo receptor 1 antagonist...
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- 801 Views
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Last post by frodo
Fri Feb 23, 2018 2:14 am
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Last post by frodo
Sat Feb 17, 2018 7:36 am
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Last post by frodo
Sat Feb 10, 2018 9:33 am
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EBV virus: Astrocytes and microglia (and B-cells) infected.
Replies: 1
by
frodo » Mon Feb 05, 2018 9:57 am
First post
Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.
Abstract
Multiple...
Last post
And related to the problem with Microglia:
Significance and in vivo detection of iron-laden microglia in white matter multiple sclerosis lesions...
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Last post by frodo
Mon Feb 05, 2018 1:48 pm
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There is damage after the lesion
by
frodo » Mon Feb 05, 2018 9:46 am
Maybe it is something that we knew, but now there is proof. After the MS lesion appears, the tissue damage continues.
Evidence of progressive tissue...
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Last post by frodo
Mon Feb 05, 2018 9:46 am
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Last post by frodo
Mon Feb 05, 2018 9:28 am
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Last post by frodo
Wed Jan 31, 2018 8:45 am
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review from Hans Lassman
Replies: 2
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frodo » Wed Jan 24, 2018 11:00 am
First post
Hans Lassman is one of the leaders in MS research. He does not say the word autoimmune anymore, nor speaks too much about myelin.
Multiple Sclerosis...
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soluble factors like in venous blood for example???
I would say that they have in mind something neurotoxic in the CNS ... We will have to wait for...
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Last post by frodo
Wed Jan 31, 2018 8:42 am
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Study suggests remarkable approach to MS treatment
Replies: 6
by
MSUK » Mon Feb 08, 2016 8:02 am
First post
A group of researchers at the Stanford Department of Neurology and Neurological Sciences exploring the use of a synthetic bile acid agonist in a...
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Do you have any links to research that has shown that the mice with the MS model induced using this technique, respond to treatments more akin to...
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Last post by frodo
Wed Jan 24, 2018 10:12 am
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Osteopontin
by
frodo » Mon Jan 22, 2018 5:12 am
Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis.
Abstract
Identifying a reliable...
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- 701 Views
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Last post by frodo
Mon Jan 22, 2018 5:12 am
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Finally Mystery Solved: Researchers Find The Cause of MS
Replies: 7
by
seeva » Wed Jan 17, 2018 10:36 pm
First post
DEAR FRIENDS GOOD NEWS PLEASE READ
regards
seeva
Last post
Where Rab32 is present, the team discovered that a part of the cell that stores calcium (endoplasmic reticulum or ER) gets too close to the...
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Last post by NHE
Sun Jan 21, 2018 8:48 am
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Last post by frodo
Thu Jan 11, 2018 9:34 am
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Last post by frodo
Tue Jan 09, 2018 11:14 am
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Last post by frodo
Tue Jan 09, 2018 10:55 am
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Last post by frodo
Tue Jan 09, 2018 6:05 am
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Last post by frodo
Sat Dec 30, 2017 4:16 am
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2017 study: Pathogenic implications of Fe & Zn in MS lesions
Replies: 5
by
jimmylegs » Thu Dec 07, 2017 6:08 am
First post
Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions (2017)
Abstract
Multiple sclerosis (MS) is a chronic...
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gonna take a while to get my head around this stuff
Nutritional immunity beyond iron: a role for manganese and zinc (2010)
...The struggle for...
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Last post by jimmylegs
Sun Dec 24, 2017 9:34 am
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Plasma exchange in MS
by
frodo » Sun Dec 17, 2017 11:53 am
Plasma exchange in severe acute relapses of multiple sclerosis - Results from a Portuguese cohort.
Abstract
BACKGROUND:
Relapses in Multiple...
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Last post by frodo
Sun Dec 17, 2017 11:53 am
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Last post by frodo
Sun Dec 17, 2017 11:48 am
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Last post by frodo
Thu Dec 14, 2017 12:59 am
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biomarkers for disease activity
Replies: 2
by
frodo » Sun Oct 08, 2017 4:34 am
First post
Fluid biomarkers for disease activity in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory and degenerative central nervous system...
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Two more biomarkers. This time for microglial activation and axonal injury. This article is a review but it refers to the original research articles,...
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- 1063 Views
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Last post by frodo
Mon Dec 11, 2017 1:18 am
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Are microglia the ultimate culprit?
Replies: 2
by
frodo » Wed Dec 06, 2017 11:15 am
First post
MS lesions develop in the so-called normal appearing areas (NAWM). Pre-active lesions start developing before the blood-brain barrier (BBB) breakdown...
Last post
multifactorial thing, ms, imho. can't be nailed down to one smoking gun.
Are we really sure that it is multifactorial? We really do not know too...
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Last post by frodo
Mon Dec 11, 2017 1:14 am
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lack of a micro-RNA as a biomarker
by
frodo » Sat Dec 09, 2017 3:59 am
MicroRNAs are proposed as a biomarker of MS. When myelin is broken, some fragments of RNA appear in blood.
But a recent research has appeared...
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- 778 Views
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Last post by frodo
Sat Dec 09, 2017 3:59 am
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MS: Linking Hormones, Diet, Blood Flow, EBV, Myelin Sheath
Replies: 1
by
vesta » Thu Nov 30, 2017 5:03 am
First post
I closed my previous blog titled « Birth Control Pill Increases MS Risk » November 6, 2017 thus :
I am writing this MSCureEnigmas site to encourage...
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Thanks for the update!!! And I will take a look at your site as soon as I can.
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Last post by frodo
Wed Dec 06, 2017 11:05 am
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Last post by frodo
Wed Nov 22, 2017 6:35 am
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MS is more neurodegenerative than autoimmune
Replies: 5
by
frodo » Sun Nov 12, 2017 4:53 am
First post
NAWM or normal appearing white matter is MRI-invisible damage that appears before the MS lesions and autoimmunity.
Global loss of myelin water over...
Last post
Greetings. To be honest I don't believe in CCSVI. I want to see more evidence about it.
Kind regards, Z
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Last post by Zyklon
Wed Nov 15, 2017 11:45 am
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