MS Etiology and Pathogenesis

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EBV virus: Astrocytes and microglia (and B-cells) infected.

Last post by frodo « Mon Feb 05, 2018 1:48 pm
Replies: 1
by frodo » Mon Feb 05, 2018 9:57 am

First post

Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.

Abstract

Multiple...

Last post

And related to the problem with Microglia:

Significance and in vivo detection of iron-laden microglia in white matter multiple sclerosis lesions...

1 Replies

762 Views

Last post by frodo
Mon Feb 05, 2018 1:48 pm
There is damage after the lesion

Last post by frodo « Mon Feb 05, 2018 9:46 am

by frodo » Mon Feb 05, 2018 9:46 am

Maybe it is something that we knew, but now there is proof. After the MS lesion appears, the tissue damage continues.

Evidence of progressive tissue...

0 Replies

738 Views

Last post by frodo
Mon Feb 05, 2018 9:46 am
Biomarkers: MRZ reaction distinguish MS and other disorders

Last post by frodo « Mon Feb 05, 2018 9:28 am

by frodo » Mon Feb 05, 2018 9:28 am

The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis.

Some rheumatologic...

0 Replies

680 Views

Last post by frodo
Mon Feb 05, 2018 9:28 am
More clues about retroviruses (HERV) involvement

Last post by frodo « Wed Jan 31, 2018 8:45 am

by frodo » Wed Jan 31, 2018 8:45 am

Subsets of activated monocytes and markers of inflammation in incipient and progressed multiple sclerosis.

Multiple sclerosis (MS) is an immune...

0 Replies

816 Views

Last post by frodo
Wed Jan 31, 2018 8:45 am
review from Hans Lassman

Last post by frodo « Wed Jan 31, 2018 8:42 am
Replies: 2
by frodo » Wed Jan 24, 2018 11:00 am

First post

Hans Lassman is one of the leaders in MS research. He does not say the word autoimmune anymore, nor speaks too much about myelin.

Multiple Sclerosis...

Last post

soluble factors like in venous blood for example???

I would say that they have in mind something neurotoxic in the CNS ... We will have to wait for...

2 Replies

856 Views

Last post by frodo
Wed Jan 31, 2018 8:42 am
Study suggests remarkable approach to MS treatment

Last post by frodo « Wed Jan 24, 2018 10:12 am
Replies: 6
by MSUK » Mon Feb 08, 2016 8:02 am

First post

A group of researchers at the Stanford Department of Neurology and Neurological Sciences exploring the use of a synthetic bile acid agonist in a...

Last post

Do you have any links to research that has shown that the mice with the MS model induced using this technique, respond to treatments more akin to...

6 Replies

1720 Views

Last post by frodo
Wed Jan 24, 2018 10:12 am
Osteopontin

Last post by frodo « Mon Jan 22, 2018 5:12 am

by frodo » Mon Jan 22, 2018 5:12 am

Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis.

Abstract

Identifying a reliable...

0 Replies

695 Views

Last post by frodo
Mon Jan 22, 2018 5:12 am
Finally Mystery Solved: Researchers Find The Cause of MS

Last post by NHE « Sun Jan 21, 2018 8:48 am
Replies: 7
by seeva » Wed Jan 17, 2018 10:36 pm

First post

DEAR FRIENDS GOOD NEWS PLEASE READ

regards
seeva

Last post

Where Rab32 is present, the team discovered that a part of the cell that stores calcium (endoplasmic reticulum or ER) gets too close to the...

7 Replies

1043 Views

Last post by NHE
Sun Jan 21, 2018 8:48 am
From the herpes virus research front (HERV)

Last post by frodo « Thu Jan 11, 2018 9:34 am

by frodo » Thu Jan 11, 2018 9:34 am

Antibody response against HERV-W env surface peptides differentiates multiple sclerosis and neuromyelitis optica spectrum disorder.

Abstract...

0 Replies

805 Views

Last post by frodo
Thu Jan 11, 2018 9:34 am
Mitochondrial dna in ms

Last post by frodo « Tue Jan 09, 2018 11:14 am
Replies: 2
by frodo » Sat Dec 16, 2017 5:11 am

2 Replies

866 Views

Last post by frodo
Tue Jan 09, 2018 11:14 am
Abnormalities in lipid metabolism. Link to cholesterol??

Last post by frodo « Tue Jan 09, 2018 10:55 am

by frodo » Tue Jan 09, 2018 10:55 am

Could this be the reason why cholesterol lowering drugs work???

Lipid biochemical changes detected in NAWM of chronic MS by SCR imaging...

0 Replies

660 Views

Last post by frodo
Tue Jan 09, 2018 10:55 am
Circulating exosomes suppress the induction of T-cells

Last post by frodo « Tue Jan 09, 2018 6:05 am

by frodo » Tue Jan 09, 2018 6:05 am

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

Abstract

Multiple sclerosis (MS) is a T...

0 Replies

647 Views

Last post by frodo
Tue Jan 09, 2018 6:05 am
Another report against the autoimmune theory

Last post by frodo « Sat Dec 30, 2017 4:16 am

by frodo » Sat Dec 30, 2017 4:16 am

Demyelination with preferential MAG loss: A complex message from MS paraffin blocks

Abstract

Multiple sclerosis (MS) is generally considered to...

0 Replies

747 Views

Last post by frodo
Sat Dec 30, 2017 4:16 am
2017 study: Pathogenic implications of Fe & Zn in MS lesions

Last post by jimmylegs « Sun Dec 24, 2017 9:34 am
Replies: 5
by jimmylegs » Thu Dec 07, 2017 6:08 am

First post

Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions (2017)

Abstract
Multiple sclerosis (MS) is a chronic...

Last post

gonna take a while to get my head around this stuff

Nutritional immunity beyond iron: a role for manganese and zinc (2010)

...The struggle for...

5 Replies

1027 Views

Last post by jimmylegs
Sun Dec 24, 2017 9:34 am
Plasma exchange in MS

Last post by frodo « Sun Dec 17, 2017 11:53 am

by frodo » Sun Dec 17, 2017 11:53 am

Plasma exchange in severe acute relapses of multiple sclerosis - Results from a Portuguese cohort.

Abstract
BACKGROUND:

Relapses in Multiple...

0 Replies

855 Views

Last post by frodo
Sun Dec 17, 2017 11:53 am
Again: Something unknown in CSF is neurotoxic.

Last post by frodo « Sun Dec 17, 2017 11:48 am

by frodo » Sun Dec 17, 2017 11:48 am

Effect of extracellular vesicles from CSF of multiple sclerosis patients and healthy controls on astrocytes in culture

INTRODUCTION

Secretion...

0 Replies

765 Views

Last post by frodo
Sun Dec 17, 2017 11:48 am
Is axon degeneration the primary event in MS?

Last post by frodo « Thu Dec 14, 2017 12:59 am

by frodo » Thu Dec 14, 2017 12:59 am

Some people thinks that microglia activation is the first observable event, but this article says that maybe microglia activates after axons have...

0 Replies

764 Views

Last post by frodo
Thu Dec 14, 2017 12:59 am
biomarkers for disease activity

Last post by frodo « Mon Dec 11, 2017 1:18 am
Replies: 2
by frodo » Sun Oct 08, 2017 4:34 am

First post

Fluid biomarkers for disease activity in multiple sclerosis

Multiple sclerosis (MS) is an inflammatory and degenerative central nervous system...

Last post

Two more biomarkers. This time for microglial activation and axonal injury. This article is a review but it refers to the original research articles,...

2 Replies

1020 Views

Last post by frodo
Mon Dec 11, 2017 1:18 am
Are microglia the ultimate culprit?

Last post by frodo « Mon Dec 11, 2017 1:14 am
Replies: 2
by frodo » Wed Dec 06, 2017 11:15 am

First post

MS lesions develop in the so-called normal appearing areas (NAWM). Pre-active lesions start developing before the blood-brain barrier (BBB) breakdown...

Last post

multifactorial thing, ms, imho. can't be nailed down to one smoking gun.

Are we really sure that it is multifactorial? We really do not know too...

2 Replies

784 Views

Last post by frodo
Mon Dec 11, 2017 1:14 am
lack of a micro-RNA as a biomarker

Last post by frodo « Sat Dec 09, 2017 3:59 am

by frodo » Sat Dec 09, 2017 3:59 am

MicroRNAs are proposed as a biomarker of MS. When myelin is broken, some fragments of RNA appear in blood.

But a recent research has appeared...

0 Replies

743 Views

Last post by frodo
Sat Dec 09, 2017 3:59 am
MS: Linking Hormones, Diet, Blood Flow, EBV, Myelin Sheath

Last post by frodo « Wed Dec 06, 2017 11:05 am
Replies: 1
by vesta » Thu Nov 30, 2017 5:03 am

First post

I closed my previous blog titled « Birth Control Pill Increases MS Risk » November 6, 2017 thus :

I am writing this MSCureEnigmas site to encourage...

Last post

Thanks for the update!!! And I will take a look at your site as soon as I can.

1 Replies

848 Views

Last post by frodo
Wed Dec 06, 2017 11:05 am
Even more voices against the autoimmune model

Last post by frodo « Wed Nov 22, 2017 6:35 am

by frodo » Wed Nov 22, 2017 6:35 am

Currently there is much more evidence against the autoimmune model than against any other, including the more controversial ones, like CCSVI or gut...

0 Replies

735 Views

Last post by frodo
Wed Nov 22, 2017 6:35 am
MS is more neurodegenerative than autoimmune

Last post by Zyklon « Wed Nov 15, 2017 11:45 am
Replies: 5
by frodo » Sun Nov 12, 2017 4:53 am

First post

NAWM or normal appearing white matter is MRI-invisible damage that appears before the MS lesions and autoimmunity.

Global loss of myelin water over...

Last post

Greetings. To be honest I don't believe in CCSVI. I want to see more evidence about it.

Kind regards, Z

5 Replies

1010 Views

Last post by Zyklon
Wed Nov 15, 2017 11:45 am
More about EBV involvement

Last post by frodo « Mon Nov 06, 2017 10:58 am

by frodo » Mon Nov 06, 2017 10:58 am

This study points to a low response against EBV in MS patients. Maybe the immune system in MS is unable to control EBV properly.

Low intrathecal...

0 Replies

798 Views

Last post by frodo
Mon Nov 06, 2017 10:58 am
review about body fluid biomarkers

Last post by frodo « Fri Nov 03, 2017 10:44 am

by frodo » Fri Nov 03, 2017 10:44 am

Source:

Fluid biomarkers for microglial activation and axonal injury in multiple sclerosis

Abstract

Although it is clear that the immune system...

0 Replies

811 Views

Last post by frodo
Fri Nov 03, 2017 10:44 am
more evidence against the autoimmune model

Last post by frodo « Mon Oct 23, 2017 6:34 am
Replies: 2
by frodo » Tue Aug 01, 2017 11:28 pm

First post

This article is a PDF that you can download:

Pathogenesis of Multiple Sclerosis: How Much Space is Left for Autoimmunity?

Abstract

Multiple...

Last post

More voices against the autoimmune model:

Source:

Abstract:

The inflammatory demyelinating lesions that are characteristic of multiple sclerosis...

2 Replies

1169 Views

Last post by frodo
Mon Oct 23, 2017 6:34 am
Neurofilament light chains (NFL)

Last post by frodo « Sun Oct 22, 2017 11:35 pm

by frodo » Sun Oct 22, 2017 11:35 pm

In the search of a body fluid biomarker for MS, currently the main candidate are neurofilament light chains (NFL). They are short pieces of neurons...

0 Replies

721 Views

Last post by frodo
Sun Oct 22, 2017 11:35 pm
MS is not a single disease. It is four at least.

Last post by frodo « Sun Oct 22, 2017 11:10 pm
Replies: 5
by frodo » Wed Sep 06, 2017 2:37 pm

First post

MS was defined in the XIX century as the presence of scars in the brain. They didn't know what was causing them, and they still don't know. There is...

Last post

But a bigger question is; can they cure any of them?

That's just a secondary question. The main questions are, what the hell are they? why they do...

5 Replies

1242 Views

Last post by frodo
Sun Oct 22, 2017 11:10 pm
About the lesion's evolution

Last post by frodo « Mon Oct 16, 2017 12:29 am
Replies: 4
by frodo » Thu May 25, 2017 12:12 am

First post

The first damage that appears in white matter are the so-called normal appearing white matter (NAWM) areas. Myelin at these areas is already damaged,...

Last post

About the early events in the demyelination process, it seems that axonal pathology is independent from inflammation:

In vivo characterization of...

4 Replies

1099 Views

Last post by frodo
Mon Oct 16, 2017 12:29 am
MS also affects peripheral nervous system

Last post by frodo « Mon Oct 16, 2017 12:23 am

by frodo » Mon Oct 16, 2017 12:23 am

MRN - Magnetic resonance neurography - shows damage in peripheral nerves of MS patients. This is not explained by any of the currently accepted...

0 Replies

708 Views

Last post by frodo
Mon Oct 16, 2017 12:23 am
New association of vein anomalies and MS found

Last post by frodo « Thu Oct 05, 2017 11:47 am

by frodo » Thu Oct 05, 2017 11:47 am

New association of vein anomalies and MS found on Sept. 2017. I remark the date because this has been reported already before several times

I would...

0 Replies

837 Views

Last post by frodo
Thu Oct 05, 2017 11:47 am
Study identifies biomarker for the onset & progression of MS

Last post by frodo « Wed Oct 04, 2017 12:25 pm
Replies: 1
by MSUK » Wed Sep 27, 2017 3:04 am

First post

A team of researchers have identified Opioid Growth Factor (OGF) as a novel biomarker for the onset and progression of multiple sclerosis (MS)...Read...

Last post

A team of researchers have identified Opioid Growth Factor (OGF) as a novel biomarker for the onset and progression of multiple sclerosis (MS)...Read...

1 Replies

892 Views

Last post by frodo
Wed Oct 04, 2017 12:25 pm
A review about mechanisms in PPMS

Last post by frodo « Wed Oct 04, 2017 12:24 pm

by frodo » Wed Oct 04, 2017 12:24 pm

Abstract

Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple...

0 Replies

738 Views

Last post by frodo
Wed Oct 04, 2017 12:24 pm
more evidence about EBV: microRNAs

Last post by frodo « Sat Sep 23, 2017 11:34 am

by frodo » Sat Sep 23, 2017 11:34 am

Maybe closer to an explanation for MS, and also closer to a blood test.

The identification of up-regulated ebv-miR-BHRF1-2-5p targeting MALT1 and...

0 Replies

925 Views

Last post by frodo
Sat Sep 23, 2017 11:34 am
change to SPMS could be prevented

Last post by frodo « Thu Sep 21, 2017 7:39 pm

by frodo » Thu Sep 21, 2017 7:39 pm

MIF and D-DT are potential disease severity modifiers in male MS subjects

Source:

Abstract

Little is known about mechanisms that drive the...

0 Replies

827 Views

Last post by frodo
Thu Sep 21, 2017 7:39 pm
Biomarkers for response to therapies

Last post by frodo « Tue Sep 19, 2017 1:48 am
Replies: 1
by frodo » Tue Sep 19, 2017 1:45 am

First post

Having several disease modifying drugs available, is interesting to know what kind of response is expected for each one of the different drugs in a...

Last post

And here there is a review summarising the complete situation as of 2015

Conclusions:

A lack of understanding of the cause of MS, as well as...

1 Replies

867 Views

Last post by frodo
Tue Sep 19, 2017 1:48 am
microRNA miR-155 dysregulation

Last post by frodo « Tue Sep 19, 2017 1:38 am

by frodo » Tue Sep 19, 2017 1:38 am

Authors of the article say that is not only a biomarker, but also a target for intervention. I put it here in biomarkers just to be conservative....

0 Replies

755 Views

Last post by frodo
Tue Sep 19, 2017 1:38 am
Biomarkers for diagnosis thread

Last post by frodo « Tue Sep 19, 2017 1:31 am
Replies: 14
by frodo » Sun Jul 09, 2017 4:55 am

First post

Hi all,

Biomarkers can be used not only as a diagnosis, but also as a window to the underlying pathology. Therefore I start this thread about...

Last post

Optical tomography recommended as biomarker

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.
Source:...

14 Replies

1514 Views

Last post by frodo
Tue Sep 19, 2017 1:31 am
A review of PET in MS

Last post by frodo « Fri Sep 15, 2017 6:51 am

by frodo » Fri Sep 15, 2017 6:51 am

Positron emision tomography (PET) can show things that cannot be seen under MRI. Specially interesting is that microglia, some inmune cells of the...

0 Replies

848 Views

Last post by frodo
Fri Sep 15, 2017 6:51 am
An ancestral retroviral protein identified in diabetes

Last post by frodo « Sun Sep 10, 2017 9:06 am

by frodo » Sun Sep 10, 2017 9:06 am

I post this here knowing that MS and diabetes have probably very little in common, but given that HERVs are associated to MS, we could have a similar...

0 Replies

789 Views

Last post by frodo
Sun Sep 10, 2017 9:06 am
How MS Progresses

Last post by TeresaL « Mon Sep 04, 2017 1:35 pm
Replies: 5
by vesta » Tue Apr 04, 2017 2:23 am

First post

HOW MS PROGRESSES

The French Neurologist Jean-Martin Charcot, practicing at the Parisian la Pitié-Salpetrière hospital, first described Multiple...

Last post

CCSVI helped me but improvements didn't last long, Dr Siskin out in stents that clotted within 6mos. I was taking plavix also.

5 Replies

1231 Views

Last post by TeresaL
Mon Sep 04, 2017 1:35 pm
Nitric oxide may induce mitochondrial dysfunction of oligode

Last post by Scott1 « Tue Aug 22, 2017 2:09 am
Replies: 1
by frodo » Tue Aug 22, 2017 1:14 am

First post

Insights in pathogenesis of multiple sclerosis: nitric oxide may induce mitochondrial dysfunction of oligodendrocytes.

Abstract

Demyelinating...

Last post

Hi,

Be careful about what you read into this. The 1998 Nobel prize was awarded to three men for their work on Nitric Oxide. see It wasn't described...

1 Replies

875 Views

Last post by Scott1
Tue Aug 22, 2017 2:09 am
Biomarkers for response to therapy thread

Last post by frodo « Wed Aug 16, 2017 12:13 am

by frodo » Wed Aug 16, 2017 12:13 am

Besides the biomarkers for diagnosis there are also biomarkers that can predict the response to an specific therapy. They can also shed some light...

0 Replies

965 Views

Last post by frodo
Wed Aug 16, 2017 12:13 am
PPMS specific pathology thread

Last post by frodo « Tue Aug 15, 2017 11:23 pm
Replies: 2
by frodo » Fri Aug 11, 2017 12:49 am

First post

For some things PPMS is different to normal MS. This is just the last one reported.

The relationship between cortical lesions and periventricular...

Last post

This is a long text about PPMS pathogenesis. It could be interesting.

Pathology and Pathogenesis of Progressive Multiple Sclerosis: Concepts and...

2 Replies

938 Views

Last post by frodo
Tue Aug 15, 2017 11:23 pm
MS is due to a bacteria that produce adenosylcobalamin

Last post by frodo « Tue Aug 15, 2017 11:12 pm

by frodo » Tue Aug 15, 2017 11:12 pm

This is a novel hypothesis for MS pathogenesis that the authors have called multiple sclerosis due to adenosylcobalamin deficiency . I really do not...

0 Replies

850 Views

Last post by frodo
Tue Aug 15, 2017 11:12 pm
what we know about MS as of 2017

Last post by frodo « Sun Aug 13, 2017 1:22 pm

by frodo » Sun Aug 13, 2017 1:22 pm

This is a copy of another post of Leonard. I copy and paste here to have all the references in this subforum

Source:

The causes and very...

0 Replies

1096 Views

Last post by frodo
Sun Aug 13, 2017 1:22 pm
Molecular mimicry?

Last post by frodo « Mon Aug 07, 2017 1:15 am

by frodo » Mon Aug 07, 2017 1:15 am

A new report that brings molecular mimicry again into the research field. In this case, they report that two proteins of the EBV virus could trigger...

0 Replies

836 Views

Last post by frodo
Mon Aug 07, 2017 1:15 am
Genetic link to vitamin D & MS

Last post by NHE « Sun Aug 06, 2017 2:13 am
Replies: 1
by tzootsi » Sat Aug 05, 2017 7:48 am

First post

Haven't had a chance to decipher this yet, but looks very interesting.

Last post

Thanks for posting this. Here's the abstract.

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of...

1 Replies

941 Views

Last post by NHE
Sun Aug 06, 2017 2:13 am
CSF from MS patients is toxic to neurons

Last post by frodo « Sat Aug 05, 2017 4:23 am

by frodo » Sat Aug 05, 2017 4:23 am

There are several reports about toxicity of CSF in MS patients. This is just the last one.

Bioenergetic Failure in Rat Oligodendrocyte Progenitor...

0 Replies

885 Views

Last post by frodo
Sat Aug 05, 2017 4:23 am
Ineffective immune control of EBV may cause exacerbation

Last post by frodo « Thu Aug 03, 2017 1:48 am

by frodo » Thu Aug 03, 2017 1:48 am

Ineffective immune control of EBV may cause exacerbation . That is the conclusion of this study, in which they say that normal CD8+ T-cells are able...

0 Replies

831 Views

Last post by frodo
Thu Aug 03, 2017 1:48 am

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