A forum to discuss research on the origins of MS and its development.
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Coronavirus (COVID-19): What You Need To Know
Replies: 131
by
jimmylegs » Sun Mar 15, 2020 4:10 am » in
General Discussion
First post
What You Need To Know About Coronavirus (COVID-19)
What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...
Last post
interesting potential links between COVID vulnerability, nutrition and MS:
New challenges from Covid-19 pandemic: an unexpected opportunity to...
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- 11618 Views
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Last post by jimmylegs
Sat May 30, 2020 5:06 pm
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Last post by frodo
Thu Dec 27, 2018 7:21 am
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Last post by frodo
Thu Dec 27, 2018 7:18 am
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Human endogenous retro-viruses HERVs and link to diabetes
Replies: 1
by
frodo » Sun Dec 23, 2018 5:43 am
First post
Not all the research points to EBV. HERVs could be also involved.
Preclinical research demonstrated that pathogenic HERV-W protein negatively...
Last post
Answering to myself, it seems that the HERVs retroviruses activation could be due to EBV. Therefore, it seems that all the evidence about HERV-W also...
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Last post by frodo
Thu Dec 27, 2018 7:12 am
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Last post by frodo
Tue Dec 25, 2018 9:29 am
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Atypical MS cases
by
frodo » Sat Dec 22, 2018 8:40 am
Multiple Sclerosis with atypical MRI presentation: results of a nationwide multicenter study in 57 consecutive cases.
They speak about four weird...
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Last post by frodo
Sat Dec 22, 2018 8:40 am
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Last post by frodo
Sat Dec 22, 2018 8:25 am
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PPMS vs. RRMS/SPMS pathogenesis
by
frodo » Sat Dec 22, 2018 8:15 am
Pathogenic Mechanisms associated with Different Clinical Courses of Multiple Sclerosis
In the majority of patients multiple sclerosis starts with...
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- 1040 Views
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Last post by frodo
Sat Dec 22, 2018 8:15 am
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Epstein Barr Virus review
by
frodo » Fri Dec 21, 2018 1:32 am
The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging
Conclusion
The conclusion drawn from...
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- 712 Views
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Last post by frodo
Fri Dec 21, 2018 1:32 am
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Biomarkers of the underlying process
by
frodo » Sun Dec 09, 2018 11:07 am
Cerebrospinal Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity
HIGHLIGHTS
• Microglial/myeloid...
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- 990 Views
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Last post by frodo
Sun Dec 09, 2018 11:07 am
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Last post by frodo
Sat Dec 08, 2018 12:53 am
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Last post by frodo
Sat Dec 01, 2018 12:16 am
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FINALLY AN AUTOANTIGEN - And gut microbioma connections.
Replies: 1
by
frodo » Thu Oct 18, 2018 3:06 am
First post
Before I was completely sure about MS not being autoimmune. Well, maybe I was wrong.
Let's see if this report is confirmed.
GDP-l-fucose...
Last post
More news about this. A clinical trial is coming up.
It seems that the autoimmune system can be re-educated. The same team in Zurich is trying to...
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- 850 Views
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Last post by frodo
Sun Oct 21, 2018 3:01 am
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what is an HLA DRB3 positive patient?
by
frodo » Fri Oct 19, 2018 11:17 am
Regarding my last post about an antigen found, it only appears in a group of patients that they call DRB3 positive. I have taken a look at what means...
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- 1183 Views
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Last post by frodo
Fri Oct 19, 2018 11:17 am
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National MS society web: The word "autoimmune"dissapears.
Replies: 5
by
frodo » Mon Oct 08, 2018 9:31 am
First post
After several years saying MS is an autoimmune disease that ... now they begin like this:
Multiple sclerosis (MS) is an unpredictable, often...
Last post
related
Taking into account the results of B‐cell‐depleting drugs, the production of autoantibodies as the driving force in MS pathology has...
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- 935 Views
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Last post by jimmylegs
Wed Oct 17, 2018 12:43 pm
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- 979 Views
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Last post by frodo
Sun Oct 14, 2018 12:22 pm
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- 679 Views
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Last post by jimmylegs
Sun Sep 30, 2018 4:18 am
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Interleukin 36 in MS
by
frodo » Sat Sep 29, 2018 2:46 am
Interleukin 36 is a cytokine normally associated with psoriasis. It seems that also appears disregulated in MS. It can be meassured in blood serum...
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- 608 Views
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Last post by frodo
Sat Sep 29, 2018 2:46 am
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Last post by frodo
Wed Sep 26, 2018 5:05 am
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new diagnostic protocol proposed
Replies: 2
by
frodo » Tue Sep 25, 2018 8:31 am
First post
One of the worst problems of MS is the misdiagnosis. Given the strong side effects of some drugs neurologist wanto to be sure and delay the diagnosis...
Last post
A few days ago you posted info on a blood test for diagnosing MS. Not sure is this new diagnostic protocol is necessary if the accuracy of the blood...
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- 1838 Views
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Last post by frodo
Wed Sep 26, 2018 5:02 am
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meningeal inflammation
by
frodo » Tue Sep 25, 2018 9:23 am
Abstract
The presence of leptomeningeal inflammation (LMI) in MS was first identified in 2004 and multiple subsequent studies have confirmed the...
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- 680 Views
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Last post by frodo
Tue Sep 25, 2018 9:23 am
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Last post by jimmylegs
Sun Sep 23, 2018 12:24 pm
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Last post by frodo
Sat Sep 22, 2018 9:24 am
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Familial MS could be different from normal MS
Replies: 1
by
frodo » Fri Aug 17, 2018 2:17 am
First post
Familial MS could be different from normal (sporadic) MS. They could be different diseases, needing different therapies, just like MS and NMO....
Last post
Notice that it could be related to this:
A mutation in a nuclear receptor (NR1H3) gene was detected in a familial, progressive form of multiple...
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Last post by frodo
Fri Aug 24, 2018 12:06 pm
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Last post by frodo
Fri Aug 24, 2018 12:00 pm
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Multiple Sclerosis: an "EMotional" issue. The microbian code
Replies: 10
by
hmacoli » Thu Jul 12, 2018 10:32 am
First post
This is an excerpt from my last page posted in my blog about MS as an emotional issue (not only but above)…that I would like to share with you.
It...
Last post
Thanks for the additional info. I did a quick check and the machines are available here but are very, very expensive.
I am having surprisingly good...
- 10 Replies
- 1474 Views
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Last post by ElliotB
Fri Aug 24, 2018 11:02 am
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Vitamin D levels in MS impact Epstein-Barr viral load
Replies: 1
by
frodo » Thu Aug 23, 2018 7:20 am
First post
Vitamin D levels in MS impact Epstein-Barr viral load
A study, published at ECTRIMS 2017, has revealed that serum vitamin D levels could be...
Last post
lab-supported anecdote - i've used nutritional boot camp to eradicate another's chronic EBV viral load.
took a connection of mine from being in line...
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- 855 Views
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Last post by jimmylegs
Thu Aug 23, 2018 8:32 am
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Barts blog: EBV and B-cells again
by
frodo » Tue Aug 21, 2018 3:53 am
B cell Cytokines in MS brain, may support B cell follicles.
Excerpts:
Although B cell depletion is an effective therapy of multiple sclerosis...
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- 806 Views
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Last post by frodo
Tue Aug 21, 2018 3:53 am
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For researchers: Red flags in diagnosis
by
frodo » Tue Aug 21, 2018 3:47 am
Some reports point to a 10% misdiagnosis, specially due to the appearance of lesions in MRI. It seems that non-demyelinating lesions are normal and...
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- 917 Views
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Last post by frodo
Tue Aug 21, 2018 3:47 am
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Last post by frodo
Tue Aug 21, 2018 3:36 am
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Last post by frodo
Fri Aug 17, 2018 1:44 am
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Last post by frodo
Wed Aug 08, 2018 2:57 pm
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review about neurofilaments
by
frodo » Tue Aug 07, 2018 3:10 pm
Editorial of the Multiple Sclerosis Journal
Are neurofilaments valuable biomarkers for long-term disease prognostication in MS?
Neuroaxonal...
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- 869 Views
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Last post by frodo
Tue Aug 07, 2018 3:10 pm
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- 960 Views
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Last post by frodo
Tue Aug 07, 2018 6:53 am
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Last post by frodo
Sun Jul 29, 2018 10:47 pm
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Can we tame microglia?
by
frodo » Sat Jul 28, 2018 10:53 am
It seems so.
Microglia P2X4 receptors as pharmacological targets for demyelinating diseases
Multiple sclerosis (MS) is a chronic inflammatory...
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- 792 Views
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Last post by frodo
Sat Jul 28, 2018 10:53 am
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Epstein Barr virus again
Replies: 1
by
frodo » Mon Jan 22, 2018 3:17 am
First post
Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple...
Last post
This article also points out a connection between the four patterns theory and the EBV brain infection.
It is also known that the CNS immune...
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- 1258 Views
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Last post by frodo
Sat Jul 28, 2018 9:07 am
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Last post by frodo
Thu Jul 26, 2018 11:14 pm
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Dysregulated EBV infection in MS. Old but relevant.
Replies: 2
by
frodo » Sun Jul 22, 2018 6:18 pm
First post
They know since 2007 that EBV is to blame. What are they waiting for to try antiviral therapies??
Dysregulated Epstein-Barr virus infection in the...
Last post
my 2c: correlation vs causation. i have limited but lab documented evidence of reducing both EBV viral load and food sensitivities (n=1, but not me)...
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- 869 Views
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Last post by jimmylegs
Wed Jul 25, 2018 6:46 am
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- 1005 Views
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Last post by frodo
Mon Jul 23, 2018 10:59 am
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Lesions evolution under PET
by
frodo » Mon Jul 23, 2018 10:50 am
PET (Positron imaging technology) is a imaging method able to show the molecular structure of a lesion.
Several radioligands, compounds that work as...
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- 880 Views
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Last post by frodo
Mon Jul 23, 2018 10:50 am
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- 800 Views
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Last post by frodo
Sun Jul 22, 2018 6:22 pm
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- 865 Views
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Last post by frodo
Sun Jul 22, 2018 10:26 am
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- 1084 Views
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Last post by frodo
Tue Jul 10, 2018 2:06 am
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- 1302 Views
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Last post by frodo
Thu Jul 05, 2018 1:12 am
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Last post by frodo
Wed Jul 04, 2018 4:21 am
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Last post by frodo
Wed Jul 04, 2018 3:58 am
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Barts blog: EBV in Brain
by
frodo » Tue Jul 03, 2018 2:29 am
EBV in Brain
Source:
The best evidence to date does suggest that EBV is present in both MS and control brains, but is more common in pwMS (90% vs...
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- 936 Views
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Last post by frodo
Tue Jul 03, 2018 2:29 am
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Immunoglobulins and B-cells
by
frodo » Mon Jul 02, 2018 2:13 am
It seems that B-cells are responsible for producing the oligoclonal Bands (OCB) that appear in MS. For some reason which I don't understand, the...
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- 1008 Views
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Last post by frodo
Mon Jul 02, 2018 2:13 am
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Evolution of the lesions during three years
Replies: 1
by
frodo » Mon Jun 25, 2018 11:48 pm
First post
This is a french study about how lesions evolve seeing by MRI. The article is in PDF and freely available.
Abstract : Obtaining information on...
Last post
This time lapse video spans a 12 month time frame of someone with RRMS. It is quite fascinating!
It is interesting that they (lesions) can grow,...
- 1 Replies
- 1344 Views
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Last post by ElliotB
Tue Jun 26, 2018 4:47 am
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How B-cells produce MS
by
frodo » Tue Jun 26, 2018 3:10 am
For most of the authors is not an issue anymore if B-cells are the cause of MS. The question is how they produce MS. Here there is a fully available...
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- 1105 Views
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Last post by frodo
Tue Jun 26, 2018 3:10 am
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