MS Etiology and Pathogenesis

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Last post

closer to an urine test

Last post by frodo « Thu Sep 05, 2019 6:38 am
Replies: 2
by frodo » Mon Sep 02, 2019 11:45 pm

First post

Abstract

BACKGROUND: Systemic inflammation is a marker of ill health and has prognostic implications in multiple health settings. Urinary neopterin...

Last post

Maybe it is related. It would be nice to have an update, but the problem with this kind of papers is that they are easily forgotten

2 Replies

401 Views

Last post by frodo
Thu Sep 05, 2019 6:38 am
Temelimab works. HERVs clearly implicated.

Last post by frodo « Sun Sep 01, 2019 11:14 am
Replies: 4
by frodo » Mon May 20, 2019 11:38 am

First post

Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing...

Last post

And here a new review about the role of HERVs in microglia activation, following Kremer's paper from last May.

This researchers confirm again the...

4 Replies

813 Views

Last post by frodo
Sun Sep 01, 2019 11:14 am
Ashton Embry: Multiple Factors in MS Etiology

Last post by frodo « Tue Aug 27, 2019 4:13 am
Replies: 1
by NHE » Mon Aug 26, 2019 2:56 pm

First post

Ashton Embry published a review paper in 2004 discussing multiple factors in MS etiology. Note, this paper predates CCSVI so it does not address...

Last post

I agree about the multifactiorial source of MS, but in the sense that probably there exists different kinds of MS, each one of them with a different...

1 Replies

444 Views

Last post by frodo
Tue Aug 27, 2019 4:13 am
Around 13% of MS cases are of genetic origin. 12 pathogenic variants.

Last post by frodo « Fri Aug 16, 2019 10:15 am
Replies: 1
by frodo » Tue Aug 13, 2019 7:38 am

First post

Of people diagnosed with MS, only 13% are believed to have a genetic form of the disease, but those presenting the mutations identified in this new...

Last post

Some other reports of heterogeneity:

HLA-DRB1 differences in allelic distribution between familial and sporadic multiple sclerosis in a Hellenic...

1 Replies

693 Views

Last post by frodo
Fri Aug 16, 2019 10:15 am
PPMS and SPMS may be different

Last post by frodo « Sun Aug 11, 2019 3:53 am

by frodo » Sun Aug 11, 2019 3:53 am

Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients

Abstract

Patients with primary progressive...

0 Replies

867 Views

Last post by frodo
Sun Aug 11, 2019 3:53 am
Molecular mimicry agent finally found? ANO2 and EBNA1

Last post by frodo « Sat Aug 10, 2019 10:13 am

by frodo » Sat Aug 10, 2019 10:13 am

Both EBNA-1 and Anoctamin-2 have been previously implicated. EBNA-1 is a protein of the EBV virus and ANO-2 us a protein of the family TMEM16...

0 Replies

482 Views

Last post by frodo
Sat Aug 10, 2019 10:13 am
Lipid profile of cerebrospinal fluid

Last post by frodo « Sat Aug 10, 2019 9:28 am

by frodo » Sat Aug 10, 2019 9:28 am

Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis

Discussion

MS is a chronic disease which is...

0 Replies

494 Views

Last post by frodo
Sat Aug 10, 2019 9:28 am
Plasma proteins: Closer to pathogenic types discrimination

Last post by frodo « Wed Jul 31, 2019 11:36 pm

by frodo » Wed Jul 31, 2019 11:36 pm

Plasma proteome in multiple sclerosis disease progression

Conclusions

Our results revealed eight novel biomarkers related to clinical and...

0 Replies

587 Views

Last post by frodo
Wed Jul 31, 2019 11:36 pm
Weird biomarker

Last post by frodo « Wed Jul 31, 2019 11:08 pm
Replies: 2
by frodo » Mon Jul 29, 2019 6:34 am

First post

Though I don't understand fully what they say, it seems that they have created a molecule with a fluorescent substrate surrounded by MBP proteins....

Last post

I agree. The T-cell model is dead. At least the CD4+ classic model.

2 Replies

570 Views

Last post by frodo
Wed Jul 31, 2019 11:08 pm
CSF from MS patients damage neurons in-vitro

Last post by frodo « Mon Jul 29, 2019 8:24 am
Replies: 1
by frodo » Mon Jul 22, 2019 12:56 am

First post

A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis

Abstract

Multiple sclerosis is an autoimmune demyelinating...

Last post

Comments on the previous paper. A new paper in “Brain” identifies molecular mechanisms causing neuronal damage in multiple sclerosis patients with...

1 Replies

719 Views

Last post by frodo
Mon Jul 29, 2019 8:24 am
Projection neurons. Whatever they are, they are involved.

Last post by frodo « Mon Jul 29, 2019 8:09 am

by frodo » Mon Jul 29, 2019 8:09 am

Science daily report:

Scientists have discovered that a specific brain cell known as a 'projection neuron' has a central role to play in the...

0 Replies

406 Views

Last post by frodo
Mon Jul 29, 2019 8:09 am
1/6 of the children with MS are anti-MOG+

Last post by frodo « Mon Jul 29, 2019 5:06 am

by frodo » Mon Jul 29, 2019 5:06 am

Prospective characterization of children positive for anti-MOG antibodies meeting Multiple Sclerosis diagnostic criteria

Abstract

Objective: To...

0 Replies

473 Views

Last post by frodo
Mon Jul 29, 2019 5:06 am
More about HERV's and microglia activation

Last post by frodo « Sat Jul 13, 2019 1:04 am

by frodo » Sat Jul 13, 2019 1:04 am

New review about the role of HERVs in microglia activation, following Kremer's paper from last May (available from the second post ot the thread This...

0 Replies

457 Views

Last post by frodo
Sat Jul 13, 2019 1:04 am
Extrinsic defect in B cells differentiation through alteration of T FH cells

Last post by frodo « Thu Jun 27, 2019 12:58 am

by frodo » Thu Jun 27, 2019 12:58 am

Report about a extrinsic defect in B cells differentiation through alteration of T FH cells:

Exploring T FH subsets involvement in Multiple...

0 Replies

631 Views

Last post by frodo
Thu Jun 27, 2019 12:58 am
More about Tcells. CD8+ Tcells dysregulation

Last post by frodo « Thu Jun 27, 2019 12:48 am

by frodo » Thu Jun 27, 2019 12:48 am

Alteration of CD8+ CD45RC in MS regulatory T cells functions

For the first time, we demonstrate an impairment of CD8+CD45RC(int) Tregs

We...

0 Replies

366 Views

Last post by frodo
Thu Jun 27, 2019 12:48 am
T-cells dysregulation

Last post by frodo « Tue Jun 25, 2019 7:18 am

by frodo » Tue Jun 25, 2019 7:18 am

Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy...

0 Replies

520 Views

Last post by frodo
Tue Jun 25, 2019 7:18 am
Cortical lesions and GA

Last post by frodo « Wed Jun 19, 2019 4:26 am

by frodo » Wed Jun 19, 2019 4:26 am

This paper is about the effects of Glatimer Acetate in MS, but they include a very deep review about the status of the research:

Some excerpts:...

0 Replies

458 Views

Last post by frodo
Wed Jun 19, 2019 4:26 am
Age of cells populations in MS

Last post by frodo « Wed Jun 19, 2019 4:01 am

by frodo » Wed Jun 19, 2019 4:01 am

Using Carbon14 the researchers can calculate the age of different cells (oligodendrocytes are myelin producing cells and OPC are oligodendrocyte...

0 Replies

473 Views

Last post by frodo
Wed Jun 19, 2019 4:01 am
Early MS lesions: Astrocytes involved

Last post by frodo « Wed Jun 19, 2019 3:33 am

by frodo » Wed Jun 19, 2019 3:33 am

Multiple Sclerosis: Destruction and Regeneration of Astrocytes in Acute Lesions

Abstract

There are reports that astrocyte perivascular endfeet...

0 Replies

547 Views

Last post by frodo
Wed Jun 19, 2019 3:33 am
Real PPMS passed (again) to mice

Last post by frodo « Sun Jun 02, 2019 8:03 am

by frodo » Sun Jun 02, 2019 8:03 am

This has been done previously (see for example posts or but this new result confirms again the previous results.

Intrathecal Injections of PPMS...

0 Replies

787 Views

Last post by frodo
Sun Jun 02, 2019 8:03 am
Dawson fingers in anti-MOG disease

Last post by frodo « Sat Jun 01, 2019 9:19 am

by frodo » Sat Jun 01, 2019 9:19 am

Anti-MOG disease makes around 10% of diagnosed MS patients and until now was reported only in atypical MS. Dawson fingers was considered one of the...

0 Replies

505 Views

Last post by frodo
Sat Jun 01, 2019 9:19 am
Inside-out model: supporting papers.

Last post by ElliotB « Thu May 30, 2019 7:10 am
Replies: 5
by frodo » Wed Jan 30, 2019 2:28 am

First post

The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later...

Last post

All very interesting theories, thanks for posting them!

5 Replies

965 Views

Last post by ElliotB
Thu May 30, 2019 7:10 am
Personalized medicine: Prediction of natalizumab response

Last post by frodo « Tue May 28, 2019 6:29 am

by frodo » Tue May 28, 2019 6:29 am

Identification of CD4+ T cell biomarkers for predicting the response of patients with relapsing‑remitting multiple sclerosis to natalizumab...

0 Replies

655 Views

Last post by frodo
Tue May 28, 2019 6:29 am
Neurofilament light as biomarker

Last post by frodo « Tue May 28, 2019 6:26 am

by frodo » Tue May 28, 2019 6:26 am

Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case–control studies

Conclusions

CSF...

0 Replies

488 Views

Last post by frodo
Tue May 28, 2019 6:26 am
Review about proteomics for MS biomarkers

Last post by frodo « Tue May 28, 2019 6:24 am

by frodo » Tue May 28, 2019 6:24 am

Proteomic approaches to decipher mechanisms underlying pathogenesis in MS

Full PDF:

Conclusion

Proteomic analysis of CNS tissue and body...

0 Replies

483 Views

Last post by frodo
Tue May 28, 2019 6:24 am
T-cells from MS patients are toxic to mice neurons

Last post by frodo « Tue May 28, 2019 6:15 am

by frodo » Tue May 28, 2019 6:15 am

This report points to something toxic in MS T-cells

Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central...

0 Replies

546 Views

Last post by frodo
Tue May 28, 2019 6:15 am
MS metabolic profile for MS. Closer to a blood test.

Last post by frodo « Thu May 09, 2019 3:02 am
Replies: 1
by frodo » Thu May 09, 2019 1:22 am

First post

Metabolome-based signature of disease pathology in MS

Highlights

• Six serum metabolites were predictive for MS in males.
• Results support...

Last post

And here other report about another possible blood test. By the way, TWEAK is this:

Interestingly, related to angiogenesis too.

Here comes the...

1 Replies

494 Views

Last post by frodo
Thu May 09, 2019 3:02 am
Viruses: Hypoxia and viruses reactivation. CCSVI?

Last post by Kinora « Fri May 03, 2019 1:36 pm
Replies: 6
by frodo » Sun Mar 11, 2018 10:14 am

First post

Could be this the explanation of the relationship between CCSVI and MS?

This article points out that endogenous retroviruses that are normally...

Last post

I use a bio-health device for blood flow. It is configured to increase blood flow at the capillary level though an configured, multi-layered wave...

6 Replies

1518 Views

Last post by Kinora
Fri May 03, 2019 1:36 pm
RNA signature of different lesion types in MS

Last post by frodo « Tue Apr 30, 2019 4:34 am

by frodo » Tue Apr 30, 2019 4:34 am

Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Conclusions

Our study is not...

0 Replies

381 Views

Last post by frodo
Tue Apr 30, 2019 4:34 am
How EBV causes MS

Last post by frodo « Mon Apr 22, 2019 12:40 pm
Replies: 2
by frodo » Tue Apr 16, 2019 12:52 am

First post

In this review, the authors (Khan & Hassani) propose an integrated model of EBV involvement in MS pathology

Epstein-Barr Virus in Multiple...

Last post

It would be great to have a EBV vaccine to prevent new MS cases but that would not help to the already infected people.

It seems that...

2 Replies

465 Views

Last post by frodo
Mon Apr 22, 2019 12:40 pm
Up to 10% of MS cases are due to anti-Neurofascin autoantibody

Last post by frodo « Sun Apr 14, 2019 10:18 am

by frodo » Sun Apr 14, 2019 10:18 am

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before.

This...

0 Replies

414 Views

Last post by frodo
Sun Apr 14, 2019 10:18 am
Report against division of MS in clinical types

Last post by frodo « Wed Apr 03, 2019 6:56 am

by frodo » Wed Apr 03, 2019 6:56 am

It is interesting that this is finally getting contested, because it was introduced artificially by the pharma industry to get interferons approved....

0 Replies

513 Views

Last post by frodo
Wed Apr 03, 2019 6:56 am
phd thesis about exosomes and miRNA

Last post by NHE « Tue Apr 02, 2019 10:11 pm
Replies: 1
by frodo » Tue Apr 02, 2019 3:05 am

First post

A phd thesis freely avaliable about exosomes and miRNA, in case anybody is interested.

Last post

Thanks. Here's the abstract...

Exosomal MicroRNA Signatures in Central Nervous System Diseases
Saeideh Ebrahimkhani, University of Sydney, Sep 30,...

1 Replies

374 Views

Last post by NHE
Tue Apr 02, 2019 10:11 pm
Toxicity of B Cell Products in Multiple Sclerosis

Last post by frodo « Sun Mar 31, 2019 11:30 am

by frodo » Sun Mar 31, 2019 11:30 am

Again, a new report of B-cells from MS patients secreting something toxic:

Toxicity of Released B Cell Products in Multiple Sclerosis

Abstract:...

0 Replies

423 Views

Last post by frodo
Sun Mar 31, 2019 11:30 am
Nfl increases BEFORE damage appears on MRI

Last post by frodo « Thu Mar 28, 2019 5:51 am

by frodo » Thu Mar 28, 2019 5:51 am

It seems that Nfl (neurofilament light) are an not just a biomarker, but also related to the pathogenesis and measurable WEEKS BEFORE the damage has...

0 Replies

591 Views

Last post by frodo
Thu Mar 28, 2019 5:51 am
MS are several diseases. Description of an iron responsive type.

Last post by frodo « Tue Mar 26, 2019 5:18 am

by frodo » Tue Mar 26, 2019 5:18 am

Identification of an iron-responsive subtype in two children diagnosed with relapsing-remitting multiple sclerosis using whole exome sequencing

In...

0 Replies

772 Views

Last post by frodo
Tue Mar 26, 2019 5:18 am
several types of alterations in NAWM and NAGM

Last post by frodo « Sat Mar 23, 2019 4:25 am

by frodo » Sat Mar 23, 2019 4:25 am

Exploring metabolite profiling of patients with secondary progressive multiple sclerosis

Synopsis

Proton magnetic resonance spectroscopic...

0 Replies

323 Views

Last post by frodo
Sat Mar 23, 2019 4:25 am
Microglial activation and NAWM appear together

Last post by frodo « Wed Mar 20, 2019 8:20 am
Replies: 1
by frodo » Thu May 17, 2018 1:13 am

First post

Microglial activation and NAWM appear together. A study found that microglial activation (shown by PET imaging) and Normal appearing white matter...

Last post

This report points to three levels of damage in MS, being demyelination just the second stage.

Abstract

Quantifying white matter damage in...

1 Replies

804 Views

Last post by frodo
Wed Mar 20, 2019 8:20 am
B-cells from MS patients secrete something toxic, maybe exosomes.

Last post by frodo « Sat Mar 16, 2019 3:25 am

by frodo » Sat Mar 16, 2019 3:25 am

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

Most evidence from pathological studies suggests that...

0 Replies

544 Views

Last post by frodo
Sat Mar 16, 2019 3:25 am
Polineuropaties, CDIP and NF-155 in MS

Last post by frodo « Fri Mar 15, 2019 7:16 am
Replies: 1
by frodo » Fri Mar 15, 2019 7:15 am

1 Replies

240 Views

Last post by frodo
Fri Mar 15, 2019 7:16 am
ANA-positive MS and MRZ reaction

Last post by frodo « Mon Mar 11, 2019 9:05 am

by frodo » Mon Mar 11, 2019 9:05 am

Up to 60% of MS-patients present antinuclear autoantibodies (ANAs) in CSF and may be misdiagnosed. Regardless of the question about if ANA-positive...

0 Replies

462 Views

Last post by frodo
Mon Mar 11, 2019 9:05 am
The Interaction between Viral and Environmental Risk Factors

Last post by frodo « Mon Mar 11, 2019 3:03 am

by frodo » Mon Mar 11, 2019 3:03 am

The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is a...

0 Replies

379 Views

Last post by frodo
Mon Mar 11, 2019 3:03 am
Metabolomics profile of MS

Last post by frodo « Mon Mar 11, 2019 1:49 am
Replies: 1
by frodo » Mon Mar 11, 2019 1:24 am

First post

Several viral infections mimic MS. Before immune supresion or modulation is important to be sure that there is no infection in the CNS or things...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

1 Replies

314 Views

Last post by frodo
Mon Mar 11, 2019 1:49 am
Oligoclonal bands are responsive to medication

Last post by frodo « Sun Mar 10, 2019 11:30 am
Replies: 2
by frodo » Tue Jan 15, 2019 5:39 am

First post

Cladribine reduces oligoclonal bands (OCB) in MS, and MS gets better without them. These are the conclusions of a study ( which also points to a...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

2 Replies

650 Views

Last post by frodo
Sun Mar 10, 2019 11:30 am
MSRV (MS retro-virus) and EBV interaction

Last post by NHE « Tue Mar 05, 2019 12:49 am
Replies: 1
by frodo » Mon Mar 04, 2019 5:28 am

First post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Multiple sclerosis (MS) is a disease of...

Last post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Free full text.

1 Replies

486 Views

Last post by NHE
Tue Mar 05, 2019 12:49 am
HERV and MSRV viruses implicated. Temelimab works against them.

Last post by NHE « Sun Mar 03, 2019 3:20 pm
Replies: 2
by frodo » Sat Mar 02, 2019 3:54 am

First post

MSRV is a retrovirus consistently found in MS lesions.

When active, MSRV produces a protein called MSRV-envelope protein, or MSRV-Env, which...

Last post

What is the magnetization transfer ratio? Does it correspond to gristy56's idea that it is magnetite which damages the myelin sheath and that by...

2 Replies

729 Views

Last post by NHE
Sun Mar 03, 2019 3:20 pm
NATURE: Autoreplicating T-cells involved in MS

Last post by frodo « Wed Feb 27, 2019 3:09 am

by frodo » Wed Feb 27, 2019 3:09 am

Immune-cell crosstalk in multiple sclerosis

T cells from people with multiple sclerosis are more prone to divide in vitro than are T cells from...

0 Replies

309 Views

Last post by frodo
Wed Feb 27, 2019 3:09 am
NATURE: Specific T-cells induce grey matter degeneration

Last post by frodo « Wed Feb 27, 2019 2:34 am

by frodo » Wed Feb 27, 2019 2:34 am

An important article about T-cells has been published. There are some expert comments about it available at . They say that the progressive phase is...

0 Replies

501 Views

Last post by frodo
Wed Feb 27, 2019 2:34 am
new biomarker, in blood, and maybe able to classify patients

Last post by frodo « Thu Feb 21, 2019 6:47 pm

by frodo » Thu Feb 21, 2019 6:47 pm

Long non‐coding RNA AFAP1‐AS1 is upregulated in a subset of multiple sclerosis patients

Results

AFAP1‐AS1 was upregulated in male MS...

0 Replies

508 Views

Last post by frodo
Thu Feb 21, 2019 6:47 pm
Patterns thread: Selective treatment for the four patterns

Last post by frodo « Mon Feb 18, 2019 1:47 am
Replies: 14
by frodo » Sun Nov 26, 2017 4:04 am

First post

In this post I will try to keep track of the developments in the specific treatment of the four patterns, whose existence was at first disputed, but...

Last post

Mitochondrial defects in acute multiple sclerosis lesions.

Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of...

14 Replies

2775 Views

Last post by frodo
Mon Feb 18, 2019 1:47 am

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