EBV theory of MS. Some diagrams.

[frodo]

A new paper about how EBV could lead to MS. I link the main diagram here below.

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

https://www.cell.com/trends/molecular-m ... 21)00035-6

[NHE]

Here's the full paper...

Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies
Trends Mol Med. 2020 Mar;26(3):296-310.

New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere of excitement in the MS community. B cells are now known to play a major role in disease, demonstrated by the highly impactful effect of a B cell-depleting antibody on controlling MS. The idea that a virus may play a role in the development of MS has a long history and is supported mostly by studies demonstrating a link between B cell-tropic Epstein-Barr virus (EBV) and disease onset. Efforts to develop antiviral strategies for treating MS are underway. Although gaps remain in our understanding of the etiology of MS, the role, if any, of viruses in propagating pathogenic immune responses deserves attention.

Free full text.

[DIM]

https://medicalxpress.com/news/2022-01- ... rosis.html

[NHE]

The team analyzed serum samples taken biennially by the military and determined the soldiers' EBV status at time of first sample and the relationship between EBV infection and MS onset during the period of active duty. In this cohort, the risk of MS increased 32-fold after infection with EBV but was unchanged after infection with other viruses. Serum levels of neurofilament light chain, a biomarker of the nerve degeneration typical in MS, increased only after EBV infection. The findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.

[frodo]

Thanks. We are witnessing a great moment for the research.