Tysabri rebound?

[Ernst]

There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?

[HarryZ]

There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?

Tysabri is a drug that really plays with your immune system. It can effect MS patients in different ways if one decides to stop using it.
I don't believe they know enough about the mechanism of what happens to really have an answer as yet.

Harry

[NHE]

There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?

Try doing a search for IRIS which is also known as immune reconstitution inflammatory syndrome.

[NHE]

There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?

Here are some journal articles...

Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259335/

Immune reconstitution inflammatory syndrome in patients with multiple sclerosis following cessation of natalizumab therapy.
http://www.ncbi.nlm.nih.gov/pubmed/20937940

Immune reconstitution inflammatory syndrome in natalizumab-associated PML
http://www.neurology.org/content/77/11/1061.short

Lethal Multiple Sclerosis Relapse After Natalizumab Withdrawal
http://www.ncbi.nlm.nih.gov/pubmed/23100404

These are just a few examples. There are many more.