Can you make your own?

Biotin is an emerging therapy for the treatment of secondary progressive MS.
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notasperfectasyou
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Can you make your own?

Post by notasperfectasyou » Thu Sep 10, 2015 6:28 am

We called Skips. They want $200 for a one month supply, 90ct 100mg capsules. There are a number of posts about buying the powder in bulk, but no one discusses how to make capsules. So, I'm posting what I have come up with and hoping a few of you might find other sources and check my math.

This link explains the volumes of various capsules:
http://pskills.pharm.ku.edu/phar520/dos ... psules.pdf
the volume of capsule 5 is .13ml

this link provides the density of Biotin:
http://www.guidechem.com/dictionary/en/58-85-5.html
the density is 1.267g/cm3 (1267mg/1.0ml)

based on this I'm thinking 2 #5 capsules would be about 300mg/day. What do you think? Ken

5/20/2016: additional information:

After doing all that calculating and research, it actually worked out that 300mg was FOUR #5 capsules a day, not two. I'm getting ready to reorder a new 100g bag, and I'm also going to order a #3 capsule maker so that Kim (hopefully) will only need to take 2 a day and the capsules will (hopefully) be easier to make.
Last edited by notasperfectasyou on Fri May 20, 2016 4:15 am, edited 1 time in total.
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Re: Can you make your own?

Post by NHE » Thu Sep 10, 2015 6:58 am

notasperfectasyou wrote:based on this I'm thinking 2 #5 capsules would be about 300mg/day. What do you think? Ken
You could always verify your assumptions with a good scale. For example, weigh 20 capsules or so in a tared container to get an average weight of a capsule. Next, fill some capsules. Again weigh several in a tared container. You can then calculate the average weight of the contents of the capsules. However, note that the weight will vary with how firmly you pack the capsules. With practice, you should be able to get fairly consistent weights. Another thing to consider is the dosage. I think that splitting up the biotin intake into 3 doses helps to maintain a more consistent level as the stuff gets cleared out of the body.

By the way, it's good to see you back on the forums!

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Re: Can you make your own?

Post by notasperfectasyou » Thu Sep 10, 2015 8:15 am

NHE wrote:
notasperfectasyou wrote:based on this I'm thinking 2 #5 capsules would be about 300mg/day. What do you think? Ken
You could always verify your assumptions with a good scale. For example, weigh 20 capsules or so in a tared container to get an average weight of a capsule. Next, fill some capsules. Again weigh several in a tared container. You can they calculate the average weight of the contents of the capsules. However, note that the weight will vary with how firmly you pack the capsules. With practice, you should be able to get fairly consistent weights. Another thing to consider is the dosage. I think that splitting up the biotin intake into 3 doses helps to maintain a more consistent level as the stuff gets cleared out of the body.

By the way, it's good to see you back on the forums!
Yes, you are right, I could by a small pocket scale, but I also value the exchange of ideas and group verification that we do here so well. I'm also adding (but not linking) that I've found a capsule maker on Ebay that will make #5 size capsules. Just search for "capsule machine".

Thanks for the welcome. I do miss being here. In a nutshell, I'm pulled in many directions and it's very hard to participate the way I did in the past. Can anyone tell me how Robbie is doing?
It would be really nice to be able to put links in here

If I have included a bad link, google the word "Scholar", click link for "Google Scholar". Search for the name of the paper and author in Google Scholar.

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Re: Can you make your own?

Post by NHE » Thu Sep 10, 2015 9:11 am

notasperfectasyou wrote:Thanks for the welcome. I do miss being here. In a nutshell, I'm pulled in many directions and it's very hard to participate the way I did in the past. Can anyone tell me how Robbie is doing?
I haven't seen a post from Robbie in 4 years.

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Re: Can you make your own?

Post by ElliotB » Thu Sep 10, 2015 5:51 pm

Biotin is tasteless, water soluble and is fast and easy to take with a small amount of water. Capsules, while convenient, are not absolutely necessary. A years supply of bulk pharmaceutical grade Biotin is under $200.

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Re: Can you make your own?

Post by notasperfectasyou » Sat Oct 03, 2015 1:00 pm

Update:

We got the pharma-grade Biotin. I got a #5 capsule maker and capsules. Made nearly 400 capsules today. It's a little tedious and the first hundred was very frustrating. But, got the hang of it, sort of. I can get the #5 capsule to about 70-80 mg, not the 150mg I was expecting. So Kim will take 4 a day. She's going to take 150 twice a day. If that works, I'll get the #3 size when I run out of supplies. Hopefully the larger size will be easier to work with. I think I can get the #3 to be about 150mg if I don't tamper the powder so much. The Biotin is a water soluble vitamin so measuring doesn't need to be so exact. Ken
It would be really nice to be able to put links in here

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Re: Can you make your own?

Post by PointsNorth » Fri Oct 09, 2015 9:54 pm

Good Video. I used this capsule maker for medicinal cannabis. It's cheap and easy, even fun. Buy it on Amazon. Someone said about someone said above that a number five capsule holds 150mg, so 2/day. Can someone send me a link to the best pharmaceutical grade biotin available online.

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Re: Can you make your own?

Post by CureOrBust » Sat Oct 10, 2015 12:37 am

PointsNorth wrote:Good Video. I used this capsule maker for medicinal cannabis. It's cheap and easy, even fun. Buy it on Amazon.
I bought this type, as I thought that putting on the end caps on the other one looked a little cumbersome. I went with a machine like the following.

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Re: Can you make your own?

Post by PointsNorth » Fri Oct 16, 2015 9:10 am

Help. How do you get 300 mg of 1% biotin to measure out into milliliter capsule??

PN
Albany 2010. Brooklyn 2011
Hayes inspired Calcitriol+D3 2013-2014
Coimbra Protocol 2014-16
DrG B12 Transdermal Spray 2014-16
Progesterone 2015-16
Low-Dose Immunotherapy 2015-16
My Current Regimen http://www.thisisms.com/forum/regimens-f22/topic25634.html

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Re: Can you make your own?

Post by tzootsi » Fri Oct 16, 2015 9:49 am

PointsNorth wrote:Help. How do you get 300 mg of 1% biotin to measure out into milliliter capsule??

PN
Yikes! Don't use 1%! You'll be taking a ton (99%) of filler. Use PURE biotin.

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Re: Can you make your own?

Post by PointsNorth » Fri Oct 16, 2015 10:34 am

OK. Using pure biotin.

I want to spread the 3 mg over 2-3 capsules. I just need to to know how many ml milliliters (volume) that 3 milligrams of pure biotin takes up in ml so I can choose a gelcap size/machine to use.

Thx, PN
Albany 2010. Brooklyn 2011
Hayes inspired Calcitriol+D3 2013-2014
Coimbra Protocol 2014-16
DrG B12 Transdermal Spray 2014-16
Progesterone 2015-16
Low-Dose Immunotherapy 2015-16
My Current Regimen http://www.thisisms.com/forum/regimens-f22/topic25634.html

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Re: Can you make your own?

Post by ElliotB » Fri Oct 16, 2015 12:48 pm

PointsNorth, you need to get a milligram scale and measure out 100 milligrams to get your answer. Scales are inexpensive, many under $30 on Amazon and eBay.

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Re: Can you make your own?

Post by notasperfectasyou » Sat Oct 17, 2015 9:10 pm

Here are the 4 things I bought:
1) #5 capsule machine on ebay for $95 from skssteve
2) AWS ZEO-50 Milligram Scale Laboratory Balance 50g x 0.001g American Weigh on Amazon for $40
3) Empty Hard Gelatin Capsule Size 5 (Tiny), 1000/bag on Amazon for $37
4) 100g bag of pure biotin from bulksupplements.com for $190

Watching Kim walk up the stairs tonight, alternating steps like non-disabled people do - Priceless.

Putting post here: http://www.thisisms.com/forum/antibioti ... 5-165.html
It would be really nice to be able to put links in here

If I have included a bad link, google the word "Scholar", click link for "Google Scholar". Search for the name of the paper and author in Google Scholar.

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Re: Can you make your own?

Post by oceanbreeze » Thu Nov 05, 2015 12:14 pm

Hi all,
I don't make capsules but just measure 100 mg on my scale and then sprinkle on food three tomes a day. I don't mind the taste, just a little chalky.
BTW, anyone buying bulk, there is a sale now on Biotin Pure at Bulk Supplements.com. Every little bit helps, right?

OceanBreeze

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Re: Can you make your own?

Post by Anunymouse » Thu Nov 05, 2015 1:15 pm

Enter PROLINE as a coupon code, 10% off and 5-7 day shipping is free. That makes about a years worth of 300g doses for about $170, so about $.50/day. Along with a 500g digital scale from ebay for 5.28, 2 water bottles (1 for work and the 2nd when you get home) coupled with some squeeze flavoring and it's a fairly inexpensive route to try the therapy. And I should be drinking more water and less soda at work anyway :)

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