A lot of the info posted above is beyond me but in layman's terms, a major issue/side effect with Clemastine that was brought up at the seminar is that the drug causes drowsiness, an obvious no no for pwMS.
Here is some additional info about the speaker conducting the seminar:
http://profiles.ucsf.edu/jonah.chan
He is quite an accomplished Doctor/Researcher. Here is some basic info about him from his UCSF profile:
Dr. Jonah R. Chan received his BS in Biochemistry and PhD in Neuroscience at the University of Illinois at Urbana-Champaign. He completed a postdoctoral fellowship in the Department of Neurobiology at Stanford University with Dr. Eric Shooter. Jonah is currently the Debbie and Andy Rachleff Distinguished Professor of Neurology. He is a member of the Neuroscience Graduate Program and the MS Research Center at UCSF.
The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Myelination is one of the most exquisite examples of cell-cell interaction found in nature and functions to maximize the efficiency and velocity of action potentials transmitted throughout the nervous system. While much has been learned about the global determinants that generate myelin-forming cells during development, the Chan laboratory is particularly interested in understanding how local environmental cues control the spatiotemporal regulation of differentiation and myelination, including both molecular and biophysical interactions. Identification of an environment that is conducive for myelination could have important implications for efforts aimed at promoting repair and remyelination in the nervous system.
Here is some additional info about his research:
http://jonahchanlab.com/about/
