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2025 Mar
Department of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Chin Akkermansia muciniphila Modulates Central Nervous System Autoimmune Response and Cognitive Impairment by Inhibiting Hippocampal NLRP3-Mediated Neuroinflammation https://pubmed.ncbi.nlm.nih.gov/40050112/
Conclusion: Our results suggest that A. muciniphila holds promise as a probiotic for treating NLRP3-associated inflammatory disorders and cognitive impairment, including MS.
2025 Oct 13
Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, United States Colonization by Akkermansia muciniphila modulates central nervous system autoimmunity in an ecological context-dependent manner https://pubmed.ncbi.nlm.nih.gov/41159034/
Results: We found that A. muciniphila colonization increased EAE severity only in a specific microbiome context, in conjunction with increased Th17 responses and CNS-infiltrating immune cells. Profiling of gut microbiome composition revealed that A. muciniphila colonization drove a reduction of Clostridia, key producers of SCFAs, specifically in the microbiome model in which A. muciniphila exacerbates EAE. Inferred metagenomic analyses suggested reduced SCFA production in the presence of A. muciniphila, which was confirmed by mass spectrometry. Consistently, provision of high dietary fiber as a substrate for SCFA production suppressed EAE only in the context of the Clostridia-rich microbiome sensitive to A. muciniphila colonization.
Discussion: Taken together, our data suggest that the effect of A. muciniphila on CNS autoimmunity is highly dependent on the overall composition of the gut microbiome and suggest that this microbe may contribute to decreased gut SCFA metabolism in multiple sclerosis.
It's an interesting study but keep in mind this looks like it was done on mice or in a lab setting. I’ve been following gut health research for MS for a while and while probiotics are great, they aren't a total fix. Definitely talk to your neuro before starting any new high-dose supplements.
