Conscientiousness

[Petr75]

2019 Jun 20
Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA/ Jacobs Multiple Sclerosis Center for Treatment and Research, Department of Neurology
Trait Conscientiousness predicts rate of brain atrophy in multiple sclerosis.
https://www.ncbi.nlm.nih.gov/pubmed/31219390

Abstract
BACKGROUND:
Conscientiousness is a core personality trait with favorable prognosis in neuropsychiatric disease.
OBJECTIVE:
We aimed to determine whether baseline Conscientiousness predicts future brain atrophy in multiple sclerosis (MS) after accounting for demographic and basic clinical characteristics.
METHODS:
Trait Conscientiousness, clinical features, and Expanded Disability Status Scale (EDSS) were obtained at baseline. Lateral ventricle volume (LVV) was measured longitudinally. In a retrospective general linear mixed effects model, data from 424 patients were analyzed (mean 6 time-points, up to 15 years).
RESULTS/CONCLUSION:
We observed significant age and Conscientiousness by time-from-baseline interactions indicating that younger age and higher Conscientiousness are associated with reduced progression of brain atrophy.