Autonomic Dysfunction in MS: Exercise Implications

[jimmylegs]

Autonomic Dysfunction in Multiple Sclerosis: Implications for Exercise (2014)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852554/

"... Conclusion
Compounding evidence now indicates that regular exercise without a critical attendant heat strain is beneficial to individuals with MS, and should be incorporated into their overall disease management plan (23, 28, 38). However, it is clear that MS patients typically engage in significantly less physical activity relative to their healthy counterparts (27, 28). Unclear is how the sequela of MS in the form of cardiovascular and thermoregulatory autonomic dysfunction impacts exercise tolerance and capacity and more importantly, what exact physiological mechanisms are contributing to these dysfunctions. If these mechanisms can be identified, appropriate therapeutic and/or pharmacological interventions can be developed to reduce their impact on exercise and heat tolerance, ultimately increasing not only health but also quality of life of MS patients."