"Human Endothelin-1 Immunoassay
For the quantitative determination of endothelin-1 (ET-1) concentrations in cell culture supernates, serum, plasma, and urine.
FOR RESEARCH USE ONLY.
NOT FOR USE IN DIAGNOSTIC PROCEDURES."
Maybe the diagnostic test version of it would be cheaper? Or maybe there is no diagnostic test available yet, I couldn't find one. But a person could always call up a human blood work lab and ask.
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Once Jeff has been on the endothelial health program for several months, his blood numbers stabilized and were in a normal range.
ESR, also known as SED rate---
http://labtestsonline.org/understanding ... r/tab/testThe erythrocyte sedimentation rate (ESR) is an easy, inexpensive, nonspecific test that has been used for many years to help detect conditions associated with acute and chronic inflammation, including infections, cancers, and autoimmune diseases. ESR is said to be nonspecific because increased results do not tell the doctor exactly where the inflammation is in the body or what is causing it, and also because it can be affected by other conditions besides inflammation. For this reason, the ESR is typically used in conjunction with other tests.
Liver enzymes---AST and ALT
Jeff's liver enzymes were 10x normal at his first flare and diagnosis. His neuro told him to "stop drinking alcohol"...and when I told her Jeff didn't drink, she rolled her eyes. As I learned in the next two years, elevated liver enzymes are a sign of endothelial dysfunction.
http://cardiovascres.oxfordjournals.org ... 2/227.fullThe main side effect of ET-1 antagonists is the increase of liver enzymes likely due to an accumulation of bile salts cytotoxic to hepatocytes.
homocysteine levels --these are often high when there is a lack of adequate B vitamins. But they are also high when there is too much endothelin 1 in the plasma.
Hope this info helps...but we should continue to ask why the endothelin 1 levels are so high in pwMS...I don't think it's because you're all hitting the bottle, as Jeff's neurologist assumed. I think it's because CCSVI is creating venous insufficiency and endothelial dysfunction.
Jeff no longer has high SED rate, high liver enzymes, petechiae or jaundice. He also has working jugular veins.
dx dual jugular vein stenosis (CCSVI) 4/09
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Indian National Snakebite Protocol Consultation MeetingCece wrote:www.mpbio.com/product_info.php?open=&cP ... ountry=223Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to Endothelin-1.
2nd August 2007
http://files.meetup.com/1166925/Snakebi ... a_2007.pdf
I read section Anti Snake Venom (ASV) - p.12 of the pdf .