The effect of pregnancy

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The effect of pregnancy

Post by gibbledygook » Thu Apr 19, 2012 7:40 am

My experience of pregnancy is that it is seriously disabling. I really wouldn't trust a neurologist who claims that pregnancy will make you feel better.

Here's an interesting piece suggesting much faster conversion to CIS after pregnancy:
Mult Scler. 2012 Feb 2. [Epub ahead of print]
Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort.
Lebrun C, Le Page E, Kantarci O, Siva A, Pelletier D, Okuda D.
Club Francophone de la Sclerose en Plaques, CHU Nice et CHU Rennes, France.
Background: In multiple sclerosis (MS), the relapse rate declines during pregnancy and increases during the first three months post-partum before returning to the pre-pregnancy rate. It is unknown whether pregnancy impacts the risk of clinical conversion in those within the presymptomatic period.Objectives: We investigate the impact of pregnancy on developing a clinical event in women diagnosed with radiologically isolated syndrome (RIS).Methods: All women with RIS underwent clinical and radiological assessments as part of an observational, prospective, longitudinal study. Clinical and MRI outcomes were analyzed during and after pregnancy. Subjects who became pregnant were compared with an age-matched female RIS group who did not become pregnant during the same follow-up period.Results: A total of 60 women with RIS were followed for up to seven years. Among them, seven became pregnant and were compared with 53 age-matched control women with RIS who did not become pregnant during the observation period. A significantly shorter time of conversion to the first neurological event was observed in the pregnant group [15.3 months (10-18)] compared with the non-pregnant controls [35.7 months (8-76)], yielding an absolute difference of 20.4 months (p<0.05). The mean (SD) number of active lesions on a subsequent brain MRI scan was significantly higher in the pregnant group [3.2 (±1.7)] compared with the control group [1.8 (±0.6)].Conclusions: The risk for clinical conversion from RIS to a clinical event and new MRI disease activity seems to be influenced by pregnancy. Pregnancy related physiological changes could operate as early as the presymptomatic period in patients with MS.
PMID: 22300971 [PubMed - as supplied by publishe
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Re: The effect of pregnancy

Post by jimmylegs » Thu Apr 19, 2012 1:09 pm

it's quite the zinc drain, that's for sure (among lots of other things of course)!
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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