A multicenter research team led by Cedars-Sinai neurologist Nancy Sicotte, MD, an expert in multiple sclerosis and state-of-the-art imaging techniques, used a new, automated technique to identify shrinkage of a mood-regulating brain structure in a large sample of women with MS who also have a certain type of depression...... Read More - http://www.ms-uk.org/technology
http://www.scientificamerican.com/podca ... -10-07-03/....recent research published in the journal Biological Psychiatry describes a physical connection between MS and mood.
Using magnetic resonance imaging (MRI) scientists found that the hippocampus, the brain area responsible for long-term memory, is smaller in people suffering from MS than in healthy adults.
They found a connection between this atrophy in the hippocampus and a hyperactivitiy in the hypothalamic-pituitary-adrenal axis (or HPA axis) in MS sufferers. The HPA axis is part of the neuroendocrine system that manages stress.
The authors note that this link between hyperactivity in the HPA and an atrophied hippocampus is consistently seen in those with chronic depression, yet this correlation has never been studied in MS patients.
Those with hypoxic injury show atrophy of the hippocampus and hyperactive HPA axis.
Here are some studies:
Several reports suggest that the activity of the hypothalamo-pituitary-adrenal axis (HPA-axis) is increased following hypoxia/ischaemia and that this might be associated with increased neuronal vulnerability-
Hypoxia damages multiple organ systems especially those with high oxygen utilization such as the central nervous system. The purpose of this study was to compare the neuropathological and neuropsychological effects of hypoxia in patients with either carbon monoxide poisoning or obstructive sleep apnea. Neuroimaging revealed evidence of hippocampal atrophy in both groups.
http://journals.cambridge.org/action/di ... aid=195135
http://ccsviinms.blogspot.com/2010/07/s ... s-and.html
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