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More or less half quantity of Na-R-ALA is needed compared to R-ALA or R/S-ALA, perfect! I would not put R-Lipoic Acid and racemic R/S-Lipoic Acid (aka Alpha Lipoic Acid) in the same basket. The R and S enantiomers are not equivalent. The S enantiomer has a physiological cost ...

Here's a study I posted a while back. It found increased Cmax and AUC for Na-R-Lipoate vs. R-Lopic Acid.

viewtopic.php?t=31875

DIM wrote: ↑Sun May 19, 2024 1:19 pm 20 mg/kg/d is too much ALA and costs a lot.
They don't mention what type of ALA they use.

Unless a paper specifies R-Lipoic Acid or Na-R-Lipoate, I think it's safe to assume that Alpha Lipoic Acid refers to racemic R/S-Lipoic Acid.

Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination Int Immunopharmacol. 2023 May:118:110125. Multiple sclerosis (MS) is a complex and multifactorial neurodegenerative disease with unknown ...

... mentioned: https://www.amazon.com/Vegan-Labs-Antioxidant-Protection-Supplement/dp/B0C6X5H3HL/ According to the label, that supplement is regular R-Lipoic acid. It's not Na-R-lipoate. In addition, cheaper is not always better with supplements. There are many companies that simply purchase ingredients ...

... reasonably priced too: https://www.amazon.com/Stabilized-R-Alpha-Increased-Absorption-R-Lipoate/dp/B07DP8DHBH/ The Life Extension Super R-Lipoic product that Jaded posted, as well as the supplement I take, Doctor's Best Stabilized Na-R-Lipoate , contains the same ingredient, i.e., the ...

I take this one and on closer inspection I think it might be Na- RALA - see the back. https://www.lifeextensioneurope.com/super-r-lipoic-acid-eu Yes, that's the stabilized version with better absorption. The brand I take suggests taking it on an empty stomach. Do you do that? I take mine ...

Hi Jaded,

Jaded wrote: ↑Fri Dec 08, 2023 3:33 pm Still it is interesting that the R lipoic acid I just paid a fortune for isn't well absorbed.

I would keep it refrigerated. Perhaps you can find a local supplier of Na-R-Lipoate once you've finished your current supply of R-Lipoic acid.

Thanks for posting. Here are some of my thoughts on the video. Regarding R-Lipoic acid, it’s been known since the 1950’s that R-Lipoic acid easily polymerizes and is poorly absorbed reducing its efficacy. https://tinyurl.com/lipoic-acid-polymers A better form ...

... with injections. Five years of Rebif is enough :) I took Avonex for 10 years. A once a month injection of Kesimpta would be no big deal for me. Lipoic acid seems promising. I just want to see some phase 3 studies. Dennis Bourdette’s research group at Oregon Health Science University has been ...

... : Ninety-six articles were summarized in this narrative review. In total 21 categories of nutrients and phytonutrients were included, i.e., α-lipoic acid, Bacopa monnieri, B vitamins, cholinergic precursors, vitamin D, vitamin E, Ginkgo biloba, ginseng, lion's mane mushroom, N-acetyl cysteine, ...

... to add it to your regimen. It seems to do fairly well slowing down atrophy. Here’s a link to news about a small phase 2 study which found that lipoic acid prevented atrophy better than Ocrevus. https://www.medicalnewstoday.com/articles/318225 Atrophy appears to be a critical factor. Atrophy ...

... with food or not can make a difference. Some supplements are best with food, e.g., B vitamins, and some are best without, e.g., probiotics and lipoic acid. There are other things to consider as well such as the form a compound is in. For example, is your lipoic acid “alpha lipoic acid” or is ...

See my recent post in the Natural Approach forum.

Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain

Also...

Na-R-lipoic acid is better absorbed than R-lipoic acid

Lipoic Acid: R vs. S

Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain Bioorg Med Chem. 2022 Sep 1;69:116889. Multiple sclerosis-associated central neuropathic pain (MS-CNP) is difficult ...