Search found 24 matches

by Degerlache
Wed May 09, 2007 4:30 am
Forum: General Discussion
Topic: Pioglitazone / reduction of brain atrophy
Replies: 0
Views: 1844

Pioglitazone / reduction of brain atrophy

Hey, The brain atrophy impact seems to be a very positive element and very consistent with the previous case-study where PIO was used for a person with progressive MS. Hopefully there will be continuation on this research. Best Regards, Degerlache ----------------------------------------------------...
by Degerlache
Wed Dec 20, 2006 12:55 am
Forum: General Discussion
Topic: More EBV research
Replies: 1
Views: 1463

Hey, Recalculating back the percentages, they have in this study only 2 (!!) out of 147 MS children that are not carrier of the EBV specific antigens. That is only 2 away from being able to suggest that EBV is to consider as a necessary "pre"condition (= not the same as the cause) for developping MS...
by Degerlache
Tue Dec 12, 2006 4:59 am
Forum: Tcelna (Tovaxin)
Topic: T-Cell Vacine & Tovaxin
Replies: 5
Views: 2822

Hey, To go into more detail about this, the link between the previous Dr. Willems Institute (but a few years ago the name was changed to Biomed) is Dr. Zangh, currently associated with FarmaFrontiers. Dr. Zangh (co)developped the T-cell technique in the 90's at this institute before going to the Sta...
by Degerlache
Fri Dec 01, 2006 5:43 am
Forum: General Discussion
Topic: Possible MS or Stress and Anxiety?
Replies: 10
Views: 4701

Hello, It was not mentionned specifically what type of blood analysis was done. But if you do not have the results at hand,re-check specifically level of B12 vit., as persons unable to absorb B12 via food get low level of B12 resulting in myelin destruction and neurological symptoms as well. Regards...
by Degerlache
Tue Oct 17, 2006 3:54 am
Forum: General Discussion
Topic: B-cell research
Replies: 12
Views: 4220

This seems to confirm the theories that there are 2 processes going on, on the one hand the inflammation and demyelination (T-cells) and on the other hand the axonal damage (becoming clear now that it is coming from the B-cells). In this light there is the publication of Prineas where he stated that...
by Degerlache
Fri Oct 06, 2006 4:43 am
Forum: General Discussion
Topic: EBV
Replies: 16
Views: 3866

Hello, If looking for a connection to insulin, there is to remind the pioglitazone (ACTOS) case story, reversing a secondary progressive case of MS and there should currently be a phase II trial on pioglitazone (but didn't hear anything about it for some time). ACTOS is a medicine (PPARgamma agonist...
by Degerlache
Fri Oct 06, 2006 2:10 am
Forum: Tysabri (Antegren or Natalizumab)
Topic: Tysabri and Diabetes
Replies: 4
Views: 3122

Hey, So little is already knows about possible interactions and links. For instance, ACTOS (pioglitazone), used against diabetes, prevented in a case study progression of secondary progressive MS and seriously improved the situation of that person and is now evaluated in a phase II study. It would a...
by Degerlache
Fri Oct 06, 2006 1:36 am
Forum: General Discussion
Topic: EBV
Replies: 16
Views: 3866

Hey, There are already serious indications about involvement of EBV as - a study on nurses with blood samples dated before their start of MS showing very specific reactions agains EBV in persons later having MS, - In studies persons with MS are 100% infected with EBV, while in general it is only abo...
by Degerlache
Mon May 22, 2006 1:20 am
Forum: General Discussion
Topic: EBV / MS Think Tank
Replies: 19
Views: 7779

Thanks for this fantastic piece of information. Proving causation may not yet be possible, but using basic logical techniques some conclusions can and should already be possible I beleive, as eg. If 100% of persons with MS test positive for EBV, while only 90% of the overall population tests EBV pos...
by Degerlache
Fri May 19, 2006 4:55 am
Forum: General Discussion
Topic: EBV / MS Think Tank
Replies: 19
Views: 7779

Stick to the numbers ! There are some publications suggesting that nearly all (if not all) MS sufferers are infected by EBV while for the rest of the people the infection level is only at 95-97%. The difference of the 5 à 3% may not look so much, but if it would be confirmed on large scale studies, ...
by Degerlache
Thu Apr 27, 2006 1:45 am
Forum: Drug Pipeline
Topic: 15d-PGJ(2)
Replies: 4
Views: 2579

Hey, The 15D-PGJ2 thing is not really a drug, but a prostaglandin that is created naturally within our body out of arachidonic acid which itself is coming from animal fat. (What is remarkable as many natural therapies seem to avoid animal fat) 15D-PGJ2 is a natural PPARgamma agonist. More and more r...
by Degerlache
Tue Apr 04, 2006 5:35 am
Forum: General Discussion
Topic: EBV
Replies: 4
Views: 1898

If EBV is actively involved in MS, it would theoretically be consistent with the potentional benfit of PPARgamma agonists. I can't find any specific studies of the effect of PPARgamma on EBV, but there seems to be general information that PPARgamma suppresses virus replication including HIV, so mayb...
by Degerlache
Fri Mar 24, 2006 3:30 am
Forum: Natural Approach
Topic: PARACTIN
Replies: 0
Views: 2381

PARACTIN

After new articles on the potential benefits of PPARgamma agonists, I looked for "natural" PPARgamma agonists and found a product called "PARACTIN". They clame to be a natural PPARgamma agonist, also used for arthritis etc....

Anyone heart of PARACTIN before ?

Regards,
Degerlache
by Degerlache
Tue Mar 21, 2006 7:05 am
Forum: Drug Pipeline
Topic: Rituximab
Replies: 4
Views: 2618

Ian, I am very interested to hear on this site about new discoveries in the EBV area. As we are talking about votes, concerning any future treatments, my vote goes out to PIOGLITAZONE (as a midlong term treatment until hopefully one day the real cause and an higly effective treatment will be found) ...
by Degerlache
Tue Mar 21, 2006 2:05 am
Forum: Drug Pipeline
Topic: Rituximab
Replies: 4
Views: 2618

The following is pure speculation, as I am not a scientist, but as a hypothesis the benefit of statins in MS, may also go via the link of EBV.

(No need to explain I am not a strong believer of the auto-immunity strategy to combat MS)

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