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Amelia: The short answer is that 9% develop antibodies at least once and 6% develop persistent antibodies. Look at www.Tysabri.com under Product Information PAGE 9 Hypersensitivity TYSABRI® has been associated with hypersensitivity reactions, including serious systemic reactions (e.g., anaphylaxis) ...

<As for the % of people whose EDSS actually improved on Tysabri...I don't believe that those numbers have ever been made public by Elan which leads me to believe that they may have not been too favorable.> Stabilization of EDSS was an endpoint of the AFFIRM study. It is captured in the 42% reduction...

Whether you believe Tysabri should come back or not, it is useful to understand the drug's efficacy. Elan did a presentation to an investor conference today, and there are some fascinating slides which illustrate the drug's effectiveness. The information is from the AFFIRM two year trial which compa...

http://www.elan.com/news/full.asp?ID=773760 "On September 26, 2005, Elan and Biogen Idec announced the submission of a supplemental Biologics License Application (sBLA) for Tysabri to the U.S. Food and Drug Administration (FDA) for the treatment of MS. The companies have requested Priority Revi...

Once again, Harry is spouting unfounded assertions. Neither the NMSS or Biogen/Elan came up with the idea of canvassing patients. It was the FDA. How do I know? Because the FDA was talking about this as far back as May 2005: after putting in the link, type "Throckmorton" and "Tysabri&...

Further to my post above, following are additional letters to the editor in the same issue of NEJM dealing with Tysabri and PML. No resolutions to be found here – just an interesting exchange: To the Editor: Kleinschmidt-DeMasters and Tyler described a patient with multiple sclerosis and PML that de...

Bromley, there are several studies of JC virus in multiple sclerosis patients (you can type in "JC Virus" and multiple sclerosis into scholar.google.com), but I have not seen that establish causality. With regards to Harry Z, I look forward to his comments. But please note that I label the...

The following letter to the editor in this month's NEJM asserts that the two Tysabri / Avonex patients who contracted PML should not have been diagnosed as having multiple sclerosis. The authors pose a fascinating question: "Is it possible to misdiagnose subclinical nonfatal cases of PML as mul...

You should know that the author of the article is a geologist, with no medical training whatsoever.

http://gsc.nrcan.gc.ca/org/calgary/rese ... php?id=261

Keep in mind Harry that Dr. Wynn has accepted monetary compensation from Serono for the promotion of Rebif. http://my.webmd.com/content/chat_transcripts/1/102562.htm http://www1.nmss.org/AZA/event/event_detail.asp?e=10673 Therefore, his questioning as to why only a percentage of patients were given ...

<Again, I ask that we agree to disagree. If medical corporations are held accountable for their actions in THEIR pursuit and attempts to make money (at the expense of the patients), no matter how they are held accountable, they might be less likely to be so careless in the future, thereby benefiting...