Search found 3362 matches

by CureOrBust
Sun Oct 27, 2019 3:51 am
Forum: General Discussion
Topic: Remyelination
Replies: 12
Views: 986

Re: Remyelination

maybe this thread would of been a better place to post this item
Current advancements in promoting remyelination in multiple sclerosis (published 2019)
viewtopic.php?f=13&t=31161
by CureOrBust
Mon Sep 23, 2019 1:57 am
Forum: Drug Pipeline
Topic: Progressive MS Pipeline
Replies: 44
Views: 45379

Re: Progressive MS Pipeline

Siponimod was recently approved as Mayzent. Its on my list of exit options for discussion. However, I do not think it has been approved in Australia. I think it is still under consideration of our equivalent of the FDA i.e. the TGA (Therapeutic Goods Administration) and for Govt funding under the P...
by CureOrBust
Sun Sep 22, 2019 6:01 am
Forum: Drug Pipeline
Topic: Current advancements in promoting remyelination in multiple sclerosis
Replies: 0
Views: 205

Current advancements in promoting remyelination in multiple sclerosis

The thing I like about this paper, is that it was published 2019. But it was submitted Aug 2018. If I understand it correctly, its based on a search across PubMed & such, so nothing "new", but it saves a lot of time searching. I was wondering what was happening with anti-LINGO-1. Current advancement...
by CureOrBust
Sun Sep 22, 2019 2:37 am
Forum: General Discussion
Topic: Antiretroviral Drugs
Replies: 5
Views: 513

Re: Antiretroviral Drugs

EBV is not really a retro-viral, so I'll post elsewhere.
viewtopic.php?p=258571#p258571
by CureOrBust
Sun Sep 22, 2019 2:36 am
Forum: Drug Pipeline
Topic: Progressive MS Pipeline
Replies: 44
Views: 45379

Re: Progressive MS Pipeline

I finished my last dosing a number of months ago. However, I have notably progressed including a relapse. I am SPMS. I have received the second highest dosing. I will be discussing with the trial Neuro about coming off the trial, and starting another DMD or restarting Gilenya. Although the study is ...
by CureOrBust
Sat Sep 21, 2019 8:53 pm
Forum: General Discussion
Topic: Vibration
Replies: 5
Views: 431

Re: Vibration

Oh, pharmas regularly test against nothing, i.e., placebo. Placebo is far from nothing. Placebo is where they actually give you "something", its simply that you do not know its really nothing. It's at the core of blinded placebo trials. I have never herd of open label placebo trials. Which you are ...
by CureOrBust
Tue Jun 18, 2019 11:58 pm
Forum: Exercise and Physical Therapy
Topic: Revitive TENS
Replies: 3
Views: 305

Re: Revitive TENS

Let me start by saying I am not a physical therapist. Plain directed physical exercise may be a simple alternative you can try at home right now. For example, I noticed I found it difficult to stand from a squatted position, so I started doing deep knee bends every day, and now its easier. I often t...
by CureOrBust
Tue Jun 18, 2019 11:53 pm
Forum: General Discussion
Topic: Vibration
Replies: 5
Views: 431

Re: Vibration

Study results like the above are very questionable. They did not compare it to an alternative core strength exercise such as planking. Testing against nothing? really?
by CureOrBust
Mon Apr 15, 2019 2:03 am
Forum: General Discussion
Topic: tACS Brain Stimulation Boosts Working Memory
Replies: 3
Views: 281

Re: tACS Brain Stimulation Boosts Working Memory

Yes, one should never read anything into a scientific journal beyond what is actually stated. However, the article referenced above, as written, implied that they saw no end (ie all while they measured, for 50min). On the other hand, the article I read said there was a definite measurable end. A big...
by CureOrBust
Thu Apr 11, 2019 10:49 pm
Forum: General Discussion
Topic: tACS Brain Stimulation Boosts Working Memory
Replies: 3
Views: 281

Re: tACS Brain Stimulation Boosts Working Memory

And their working memory remained sharp for as long as the researchers continued testing it, for 50 minutes.
I remember (without stimulation) reading a similar article on the event, and I was certain that in the source I had read, the effects were transitory.
by CureOrBust
Mon Apr 01, 2019 3:54 am
Forum: Suggestions
Topic: EBV forum?
Replies: 1
Views: 462

EBV forum?

Considering how persistent the link has been between EBV and MS, it recently occurred to me that the site does not have a specific forum on the topic. I am not suggesting I would be posting heavily in an EBV forum, but I know I have over the years read a number of articles and posts regarding it, in...
by CureOrBust
Thu Mar 28, 2019 4:49 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Role of cerebral hypoperfusion in MS
Replies: 5
Views: 606

Re: Role of cerebral hypoperfusion in MS

Although the drug they tested sounds like a risky option in itself, what I do see (in the half full cup) is an opportunity to better understand the disease, and what may improve matters, by the way the drug causes its effects.
by CureOrBust
Mon Mar 18, 2019 12:16 am
Forum: Gilenya
Topic: FDA Warning on Stopping Gilenya
Replies: 5
Views: 862

Re: FDA Warning on Stopping Gilenya

NHE wrote:
Sun Mar 17, 2019 12:12 am
What trial are you joining?
I have joined, and already received my first dose for: https://clinicaltrials.gov/ct2/show/NCT03283826

NB: the nine month washout for Gilenya has been removed, but was part of the original exclusion criteria when I first applied.
by CureOrBust
Sat Mar 16, 2019 3:05 pm
Forum: General Discussion
Topic: Antiretroviral Drugs
Replies: 5
Views: 513

Re: Antiretroviral Drugs

I have found something similar. Depleting EBV with artificial T-cells also works, even in progressive stage. Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302936/ see: https://www.thisisms.com/forum/viewtopic.php?f=13&t=3...
by CureOrBust
Sat Mar 16, 2019 2:54 pm
Forum: Gilenya
Topic: FDA Warning on Stopping Gilenya
Replies: 5
Views: 862

Re: FDA Warning on Stopping Gilenya

I am not suggesting or recommending anyone to do what I did, as it was simply based on my own thoughts based no scientific basis. So, I wanted to participate in a new trial, but it had a 9 month washout period for Gilenya. So, the sooner I stopped taking it, the sooner I could start the trial. I kne...