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maybe this thread would of been a better place to post this item
Current advancements in promoting remyelination in multiple sclerosis (published 2019)
viewtopic.php?f=13&t=31161

Siponimod was recently approved as Mayzent. Its on my list of exit options for discussion. However, I do not think it has been approved in Australia. I think it is still under consideration of our equivalent of the FDA i.e. the TGA (Therapeutic Goods Administration) and for Govt funding under the P...

The thing I like about this paper, is that it was published 2019. But it was submitted Aug 2018. If I understand it correctly, its based on a search across PubMed & such, so nothing "new", but it saves a lot of time searching. I was wondering what was happening with anti-LINGO-1. Current advancement...

EBV is not really a retro-viral, so I'll post elsewhere.
viewtopic.php?p=258571#p258571

I finished my last dosing a number of months ago. However, I have notably progressed including a relapse. I am SPMS. I have received the second highest dosing. I will be discussing with the trial Neuro about coming off the trial, and starting another DMD or restarting Gilenya. Although the study is ...

Oh, pharmas regularly test against nothing, i.e., placebo. Placebo is far from nothing. Placebo is where they actually give you "something", its simply that you do not know its really nothing. It's at the core of blinded placebo trials. I have never herd of open label placebo trials. Which you are ...

Let me start by saying I am not a physical therapist. Plain directed physical exercise may be a simple alternative you can try at home right now. For example, I noticed I found it difficult to stand from a squatted position, so I started doing deep knee bends every day, and now its easier. I often t...

Study results like the above are very questionable. They did not compare it to an alternative core strength exercise such as planking. Testing against nothing? really?

Yes, one should never read anything into a scientific journal beyond what is actually stated. However, the article referenced above, as written, implied that they saw no end (ie all while they measured, for 50min). On the other hand, the article I read said there was a definite measurable end. A big...

And their working memory remained sharp for as long as the researchers continued testing it, for 50 minutes.

I remember (without stimulation) reading a similar article on the event, and I was certain that in the source I had read, the effects were transitory.

Considering how persistent the link has been between EBV and MS, it recently occurred to me that the site does not have a specific forum on the topic. I am not suggesting I would be posting heavily in an EBV forum, but I know I have over the years read a number of articles and posts regarding it, in...

Although the drug they tested sounds like a risky option in itself, what I do see (in the half full cup) is an opportunity to better understand the disease, and what may improve matters, by the way the drug causes its effects.

NHE wrote: ↑

Sun Mar 17, 2019 12:12 am

What trial are you joining?

I have joined, and already received my first dose for: https://clinicaltrials.gov/ct2/show/NCT03283826

NB: the nine month washout for Gilenya has been removed, but was part of the original exclusion criteria when I first applied.

I have found something similar. Depleting EBV with artificial T-cells also works, even in progressive stage. Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302936/ see: https://www.thisisms.com/forum/viewtopic.php?f=13&t=3...

I am not suggesting or recommending anyone to do what I did, as it was simply based on my own thoughts based no scientific basis. So, I wanted to participate in a new trial, but it had a 9 month washout period for Gilenya. So, the sooner I stopped taking it, the sooner I could start the trial. I kne...