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Sometimes mice will be raised in germ-free housing to see how that affects various things. This stupendous paper by Paul Plotz: Plotz PH. The autoantibody repertoire: searching for order. Nat Rev Immunol. 2003 Jan;3(1):73-8. Review. PMID: 12511877 cites a study in which genetically-autoimmune-prone ...

Sorry to bump up an old thread. Some of my post is about debates that are old hat here, but what can I do, I have 2 cents and want to toss em in. Raven, I think youre quite right that the Prineas apoptotic lesion could quite conceivably be caused by antibody in principle. Therefore the Prineas findi...

Gibbledygook, I am wanting to use INH, but am hesitant to let up on the doxy + tini I have used daily for the last 6 months, gaining major reversal of my once-severe CFS. So I am currently researching the safety or lack thereof of concurrent use of doxy and INH. (And tini, re which CYP450 interactio...

I havent tried to understand the Hellings & van der Aa data myself... and I dont have any idea whether they used an optimal protocol for the treatment, or whether they might have some sort of agenda for/against the treatment. But I can report that their paper says: In conclusion, we demonstrated...

I'm reading the Hellings and van der Aa paper on this treatment. They say there is indeed an anti-idiotypic response, that means the response against the particular (antimyelin) T-cell clones. But they also say there is an anti-ergotypic response, which is a response against molecules which all T-ce...

Speak of the devil, I'm doing a lil nitroimidazole research today and stumbled over this: Metronidazole is extensively metabolised by the liver to 5 metabolites. The hydroxy metabolite has biological activity of 30 to 65% and a longer elimination half-life than the parent compound. PMID: 10384859 So...

I am always careful what I believe since theres plenty of incorrect information even in the peer-reviewed literature. That said, http://www.rxlist.com/cgi/generic/metronidaz_cp.htm Disposition of metronidazole in the body is similar for both oral and intravenous dosage forms, with an average elimina...

Eric- I think your questions and observations are very thoughtfully made, but I also think you haven't delved deeply into the Cpn literature yet. ) Fair enough, I will scour the patent by and by, perhaps my thoughts will change. Conversely, if you read the Wirostko/Johnson oculitis bacteria papers ...

Sarah, I dont think the reticulate/elementary cycle is Cpns secret, since the same alternation is also found in urogenital C. trachomatis infections and Cpn pneumonias that can usually be cleared right out with abx. Its similar with acute lyme borreliosis. The majority who contract it dont get choni...

Tovaxin sounds scientifically interesting. Does it cause particular subsets of T-cells to be depleted, or all T-cells? I am totally in agreement with your doubts! How can an immune suppressant help if the disease is caused by an infection? A good inquiry to make. One possibility is that because the ...

My comparison to a bladder infection upthread was kinda misleading. Intracellular bacterial infections like TB and tuleremia can take quite some time to resolve under treatment, much longer than a bladder infection. (Im not quite sure yet what all contributes to this.) So, if MS, CFS etc are in fact...

Its nice to meet you Sarah, I think I first read your story almost a year ago. Hi Jaded, I dont have MS, but slowly developed CFS in 2003-4. CFS has some common symptoms with MS (tho the mechanisms may not necessarily be the same) - fatigue, cognitive problems, allergies/sensitivities like Sarahs......

Just a note for anyone who doesnt have a rapid symptom response to abx consistent with microbe lysis. I never had these responses in a year of going on and off different abx combos for my severe Chronic Fatigue Syndrome. That is, not from any of the drugs which were my recovery workhorses. The one a...

Hmm, trying to edit here but its not working. I just wanted to add that its not black and white between rationale and experience. Not only are hamster infection data more meaningful for humans than test tube data... similarly, monkey data are more meaningful than hamster data. Conversely, patient re...

Heres a little more of my viewpoint. This is the sort of finding that informs my feeling that empirics are at least as important rationale: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=174684 The MBC is the minimum bactericidal concentration - the concentration of a given drug which wil...